HitPredict

Interactor 1: CBLB (Q3TTA7)
E3 ubiquitin-protein ligase CBL-B (EC 2.3.2.27) (Casitas B-lineage lymphoma proto-oncogene b) (RING-type E3 ubiquitin transferase CBL-B) (SH3-binding protein CBL-B) (Signal transduction protein CBL-B)
Gene: CBLB

Interactor 2: UBS3B (Q8BGG7)
Ubiquitin-associated and SH3 domain-containing protein B (EC 3.1.3.48) (Cbl-interacting protein p70) (Suppressor of T-cell receptor signaling 1) (STS-1) (T-cell ubiquitin ligand 2) (TULA-2) (Tyrosine-protein phosphatase STS1/TULA2)
Gene: Ubash3b

Species: Mus musculus

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	0.60	0.445

Property	Details
Experiments	27474268
Identification Methods	affinity chromatography technology
Interaction Type	association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0007165 - signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 982 Mm			1 638
+	Hs
		1027618 CBLB_HUMAN (1-982): 0: 926: 94.30		UBS3B_HUMAN (1-638): 0: 1043: 97.65
+	Mm
		1112052 CBLB_MOUSE (1-982): 0: 947: 100.00		UBS3A_MOUSE (1-632): 0: 959: 45.66
+	Hs
		883333 CBLB_HUMAN (1-982): 0: 926: 94.30		UBS3A_HUMAN (1-632): 0: 951: 42.92
+	Hs
		610459 CBL_HUMAN (25-976): 0: 710: 47.24		UBS3B_HUMAN (1-638): 0: 1043: 97.65
+	Hs
		610317 CBL_HUMAN (25-976): 0: 710: 47.24		UBS3A_HUMAN (1-632): 0: 951: 42.92
+	Mm
		1112053 CBLB_MOUSE (1-982): 0: 947: 100.00		GRB2_MOUSE (145-308): 1.8e-45: 162: 21.56
+	Hs
		924539 CBLB_HUMAN (1-982): 0: 926: 94.30		GRB2_HUMAN (145-308): 7.25e-46: 163: 21.56
+	Mm
		82735 B9EKI5_MOUSE (1-982): 0: 916: 90.53		GRB2_MOUSE (145-308): 1.8e-45: 162: 21.56
+	Mm
		1112072 CBLB_MOUSE (1-982): 0: 947: 100.00		GRAP_MOUSE (145-306): 3.65e-22: 97.2: 18.56
+	Hs
		1027621 CBLB_HUMAN (1-982): 0: 926: 94.30		SH3K1_HUMAN (210-364): 4.94e-27: 118: 22.93
+	Mm
		1112057 CBLB_MOUSE (1-982): 0: 947: 100.00		SRBS1_MOUSE (247-306): 4.85e-19: 94.1: 40.00
+	Hs
		235501 CBLB_HUMAN (1-982): 0: 926: 94.30		VINEX_HUMAN (218-306): 4.67e-23: 106: 26.97
+	Hs
		298976 CBLB_HUMAN (1-982): 0: 926: 94.30		SRBS2_HUMAN (219-306): 1.06e-22: 105: 26.80
+	Hs
		1027613 CBLB_HUMAN (1-982): 0: 926: 94.30		SH3R1_HUMAN (205-304): 1.79e-18: 91.8: 28.00
+	Hs
		610338 CBL_HUMAN (25-976): 0: 710: 47.24		GRB2_HUMAN (145-308): 7.25e-46: 163: 21.56
+	Hs
		610437 CBL_HUMAN (25-976): 0: 710: 47.24		Q6ICN0_HUMAN (145-308): 6.96e-45: 161: 21.56
+	Hs
		47590 CBL_HUMAN (25-976): 0: 710: 47.24		A0A8V8TNS8_HUMAN (210-364): 4.36e-28: 119: 22.93
+	Dm
		220607 O46034_DROME (27-450): 0: 729: 68.94		GRAP_DROME (141-305): 2.7e-22: 97.2: 18.07
+	Hs
		235473 CBL_HUMAN (25-976): 0: 710: 47.24		VINEX_HUMAN (218-306): 4.67e-23: 106: 26.97
+	Hs
		298949 CBL_HUMAN (25-976): 0: 710: 47.24		SRBS2_HUMAN (219-306): 1.06e-22: 105: 26.80