Protein: UBP33
Ubiquitin carboxyl-terminal hydrolase 33 (EC 3.4.19.12) (Deubiquitinating enzyme 33) (Ubiquitin thioesterase 33) (Ubiquitin-specific-processing protease 33) (VHL-interacting deubiquitinating enzyme 1) (hVDU1)

Gene: UBP33, USP33
Organism: Homo sapiens
Interactions: 141
UniProt ID: Q8TEY7

Gene Ontology (top 5):
GO:0001664 - G protein-coupled receptor binding
GO:0004197 - cysteine-type endopeptidase activity
GO:0004843 - cysteine-type deubiquitinase activity
GO:0005654 - nucleoplasm
GO:0005737 - cytoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

508328

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

2

20

Small-scale

0.778

High

242388

PRKN
E3 ubiquitin-protein ligase parkin

1

20

Small-scale

0.747

High

732655

ARRB2
Beta-arrestin-2

4

4

Small-scale

0.707

High

333117

VAPB
Vesicle-associated membrane protein-associated protein B/C

4

6

High-throughput

0.691

High

1353443

ROBO1
Roundabout homolog 1

4

4

Small-scale

0.683

High

212458

SPIT2
Kunitz-type protease inhibitor 2

3

7

High-throughput

0.667

High

946023

VSX2
Visual system homeobox 2

3

7

High-throughput

0.667

High

1353423

STN1
CST complex subunit STN1

3

2

High-throughput

0.667

High

1353418

PCGF6
Polycomb group RING finger protein 6

3

20

High-throughput

0.662

High

1353420

TKTL2
Transketolase-like protein 2

3

4

High-throughput

0.662

High

1353435

VAPA
Vesicle-associated membrane protein-associated protein A

3

6

High-throughput

0.662

High

822779

VHL
von Hippel-Lindau disease tumor suppressor

2

3

Small-scale

0.654

High

1353411

UBP28
Ubiquitin carboxyl-terminal hydrolase 28

1

19

High-throughput

0.647

High

1353436

UBP21
Ubiquitin carboxyl-terminal hydrolase 21

1

19

High-throughput

0.647

High

1353440

UBP15
Ubiquitin carboxyl-terminal hydrolase 15

1

17

High-throughput

0.647

High

1353414

CGRF1
Cell growth regulator with RING finger domain protein 1

3

0

High-throughput

0.638

High

458451

ADRB2
Beta-2 adrenergic receptor

3

3

Small-scale

0.633

High

252362

TLR2
Toll-like receptor 2

2

2

High-throughput

0.628

High

1353395

ZNRF4
E3 ubiquitin-protein ligase ZNRF4

2

11

High-throughput

0.628

High

1353415

APBA2
Amyloid-beta A4 precursor protein-binding family A member 2

2

4

High-throughput

0.628

High

1108492

TRPC3
Short transient receptor potential channel 3

1

2

High-throughput

0.618

High

857511

NOTC1
Neurogenic locus notch homolog protein 1

1

10

Small-scale

0.618

High

1147217

ELOB
Elongin-B

1

2

Small-scale

0.618

High

1353437

FBW1A
F-box/WD repeat-containing protein 1A

1

12

Small-scale

0.618

High

1353438

UBP20
Ubiquitin carboxyl-terminal hydrolase 20

1

17

Small-scale

0.618

High

1353399

IOD2
Type II iodothyronine deiodinase

3

1

Small-scale

0.616

High

1147071

ELOC
Elongin-C

2

1

Small-scale

0.595

High

1149493

SP17
Sperm surface protein Sp17

2

0

High-throughput

0.585

High

764909

CTNB1
Catenin beta-1

2

20

Small-scale

0.584

High

951296

SC61B
Protein transport protein Sec61 subunit beta

2

1

High-throughput

0.584

High

363612

EGFR
Epidermal growth factor receptor

1

13

Small-scale

0.582

High

1098650

SBP1
Methanethiol oxidase

1

1

Small-scale

0.573

High

213206

CP110
Centriolar coiled-coil protein of 110 kDa

1

2

Small-scale

0.561

High

820699

CEAM6
Cell adhesion molecule CEACAM6

1

3

High-throughput

0.553

High

539830

RALA
Ras-related protein Ral-A

1

11

Small-scale

0.552

High

539895

RALB
Ras-related protein Ral-B

1

11

Small-scale

0.552

High

788973

TGFR2
TGF-beta receptor type-2

1

19

Small-scale

0.552

High

1353433

DDX56
Probable ATP-dependent RNA helicase DDX56

1

18

High-throughput

0.541

High

289365

CTAG2
Cancer/testis antigen 2

1

1

High-throughput

0.536

High

1101860

SKP2
S-phase kinase-associated protein 2

1

7

High-throughput

0.536

High

1102495

IFIT5
Interferon-induced protein with tetratricopeptide repeats 5

1

3

High-throughput

0.536

High

1112105

KRR1
KRR1 small subunit processome component homolog

1

2

High-throughput

0.536

High

1251093

TPTE2
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2

1

9

High-throughput

0.536

High

1277590

K1C27
Keratin, type I cytoskeletal 27

1

16

High-throughput

0.536

High

1353394

CT55
Cancer/testis antigen 55

1

1

High-throughput

0.536

High

1353401

SPSB4
SPRY domain-containing SOCS box protein 4

1

20

High-throughput

0.536

High

1353405

ZDH12
Palmitoyltransferase ZDHHC12

1

2

High-throughput

0.536

High

1353409

ZFR
Zinc finger RNA-binding protein

1

11

High-throughput

0.536

High

1353424

TM134
Transmembrane protein 134

1

1

High-throughput

0.536

High

376629

TGFA
Protransforming growth factor alpha [Cleaved into: Transforming growth factor alpha

1

0

High-throughput

0.513

High

663761

IL32
Interleukin-32

1

0

High-throughput

0.513

High

1088780

NMDE1
Glutamate receptor ionotropic, NMDA 2A

1

0

High-throughput

0.513

High

1353400

TRI63
E3 ubiquitin-protein ligase TRIM63

1

20

High-throughput

0.501

High

1353419

TRI54
Tripartite motif-containing protein 54

1

20

High-throughput

0.501

High

477173

ACM5
Muscarinic acetylcholine receptor M5

1

5

High-throughput

0.494

High

276220

LRRN2
Leucine-rich repeat neuronal protein 2

1

8

High-throughput

0.489

High

595086

KCNA2
Potassium voltage-gated channel subfamily A member 2

1

2

High-throughput

0.489

High

615158

GBRG2
Gamma-aminobutyric acid receptor subunit gamma-2

1

2

High-throughput

0.489

High

1101603

GPR17
Uracil nucleotide/cysteinyl leukotriene receptor

1

4

High-throughput

0.489

High

1217825

PR38B
Pre-mRNA-splicing factor 38B

1

5

High-throughput

0.489

High

1288323

LRRT1
Leucine-rich repeat transmembrane neuronal protein 1

1

6

High-throughput

0.489

High

1353412

CRML
Protein cramped-like

1

1

High-throughput

0.489

High

1353422

TMX1
Thioredoxin-related transmembrane protein 1

1

7

High-throughput

0.489

High

1353426

RXFP1
Relaxin receptor 1

1

7

High-throughput

0.489

High

1353432

ASIC5
Bile acid-sensitive ion channel

1

6

High-throughput

0.489

High

791567

SYUA
Alpha-synuclein

1

5

High-throughput

0.481

High

170253

AURKA
Aurora kinase A

1

20

Small-scale

0.479

High

174009

AT2A1
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1

1

7

High-throughput

0.479

High

253368

JAK2
Tyrosine-protein kinase JAK2

1

20

Small-scale

0.479

High

291455

NU155
Nuclear pore complex protein Nup155

1

1

High-throughput

0.479

High

342979

HERC2
E3 ubiquitin-protein ligase HERC2

1

20

Small-scale

0.479

High

372666

MYC
Myc proto-oncogene protein

1

20

Small-scale

0.479

High

374090

RASN
GTPase NRas

1

11

High-throughput

0.479

High

375763

RASK
GTPase KRas

1

10

High-throughput

0.479

High

386014

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

20

High-throughput

0.479

High

417622

RPN1
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1

1

1

High-throughput

0.479

High

466380

RHOC
Rho-related GTP-binding protein RhoC

1

6

High-throughput

0.479

High

476004

GNAI3
Guanine nucleotide-binding protein G(i) subunit alpha-3

1

10

High-throughput

0.479

High

631369

RAB5A
Ras-related protein Rab-5A

1

5

High-throughput

0.479

High

703963

DUS1
Dual specificity protein phosphatase 1

1

9

Small-scale

0.479

High

728346

AKT1
RAC-alpha serine/threonine-protein kinase

1

12

Small-scale

0.479

High

784969

ARRC
Arrestin-C

1

4

Small-scale

0.479

High

787431

TGFR1
TGF-beta receptor type-1

1

19

Small-scale

0.479

High

837743

LAP2B
Lamina-associated polypeptide 2, isoforms beta/gamma

1

4

High-throughput

0.479

High

867997

GLR
Glucagon receptor

1

1

Small-scale

0.479

High

882537

ARRB1
Beta-arrestin-1

1

4

Small-scale

0.479

High

884369

UBE2A
Ubiquitin-conjugating enzyme E2 A

1

6

Small-scale

0.479

High

894930

EMD
Emerin

1

2

High-throughput

0.479

High

901424

RAB7A
Ras-related protein Rab-7a

1

3

High-throughput

0.479

High

962310

RHOA
Transforming protein RhoA

1

6

High-throughput

0.479

High

1014559

SMAD3
Mothers against decapentaplegic homolog 3

1

15

Small-scale

0.479

High

1056873

FMR1
Fragile X messenger ribonucleoprotein 1

1

6

Small-scale

0.479

High

1058547

CKAP4
Cytoskeleton-associated protein 4

1

20

High-throughput

0.479

High

1087212

STX4
Syntaxin-4

1

2

High-throughput

0.479

High

1113812

CUL3
Cullin-3

1

20

High-throughput

0.479

High

1126726

BECN1
Beclin-1

1

3

Small-scale

0.479

High

1135580

K2C72
Keratin, type II cytoskeletal 72

1

11

Small-scale

0.479

High

1164299

F263
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3

1

5

Small-scale

0.479

High

1333916

DHB11
Estradiol 17-beta-dehydrogenase 11

1

2

High-throughput

0.479

High

1334482

RN149
E3 ubiquitin-protein ligase RNF149

1

12

High-throughput

0.479

High

1353396

EDEM1
ER degradation-enhancing alpha-mannosidase-like protein 1

1

1

High-throughput

0.479

High

1353397

AKAP1
A-kinase anchor protein 1, mitochondrial

1

3

High-throughput

0.479

High

1353403

LRC59
Leucine-rich repeat-containing protein 59

1

4

High-throughput

0.479

High

1353408

EXOC2
Exocyst complex component 2

1

1

Small-scale

0.479

High

1353410

SNX27
Sorting nexin-27

1

13

High-throughput

0.479

High

1353416

EPAS1
Endothelial PAS domain-containing protein 1

1

14

Small-scale

0.479

High

1353430

OTULL
Inactive ubiquitin thioesterase OTULINL

1

3

High-throughput

0.479

High

1353434

ELOV5
Very long chain fatty acid elongase 5

1

1

High-throughput

0.479

High

1353441

TRAF6
TNF receptor-associated factor 6

1

20

Small-scale

0.479

High

941218

IF6
Eukaryotic translation initiation factor 6

1

0

High-throughput

0.460

High

904032

BAP31
B-cell receptor-associated protein 31

1

0

High-throughput

0.458

High

1276241

ATG9A
Autophagy-related protein 9A

1

0

High-throughput

0.458

High

1353398

SYMPK
Symplekin

1

0

Small-scale

0.458

High

1353425

TMT1A
Thiol S-methyltransferase TMT1A

1

0

High-throughput

0.458

High

1353427

PXMP2
Peroxisomal membrane protein 2

1

0

High-throughput

0.458

High

1353431

OCAD1
OCIA domain-containing protein 1

1

0

High-throughput

0.458

High

1103006

CENPR
Centromere protein R

1

1

High-throughput

0.457

High

1353429

DISC1
Disrupted in schizophrenia 1 protein

1

3

High-throughput

0.457

High

1219858

OBI1
ORC ubiquitin ligase 1

1

0

High-throughput

0.438

High

181009

LRAD4
Low-density lipoprotein receptor class A domain-containing protein 4

1

1

High-throughput

0.437

High

771637

DRD3
D(3) dopamine receptor

1

3

Small-scale

0.437

High

847620

SSRA
Translocon-associated protein subunit alpha

1

1

High-throughput

0.437

High

1111622

STIM1
Stromal interaction molecule 1

1

1

High-throughput

0.437

High

1322911

CXD3
Gap junction delta-3 protein

1

3

High-throughput

0.437

High

1353406

NEUL4
Neuralized-like protein 4

1

3

Small-scale

0.437

High

1353407

DNJC1
DnaJ homolog subfamily C member 1

1

13

High-throughput

0.437

High

1353413

SEC62
Translocation protein SEC62

1

1

High-throughput

0.437

High

1353417

DERL1
Derlin-1

1

3

High-throughput

0.437

High

947026

DSCR9
Down syndrome critical region protein 9

1

1

High-throughput

0.417

High

1353439

S27A6
Long-chain fatty acid transport protein 6

1

3

High-throughput

0.407

High

1225724

LPCT4
Lysophospholipid acyltransferase LPCAT4

2

0

High-throughput

0.328

High

1203744

TTMP
TPA-induced transmembrane protein

1

0

High-throughput

0.279

Low

1316536

MCLN2
Mucolipin-2

1

0

High-throughput

0.279

Low

1353404

I17RA
Interleukin-17 receptor A

1

0

High-throughput

0.279

Low

139940

RCAS1
Receptor-binding cancer antigen expressed on SiSo cells

1

0

High-throughput

0.249

Low

190714

MPPD1
Metallophosphoesterase domain-containing protein 1

1

0

High-throughput

0.249

Low

418299

RPN2
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2

1

0

High-throughput

0.249

Low

1353402

S2546
Mitochondrial outer membrane protein SLC25A46

1

0

High-throughput

0.249

Low

1353421

3BHS7
3 beta-hydroxysteroid dehydrogenase type 7

1

0

High-throughput

0.249

Low

1353428

ST7
Suppressor of tumorigenicity 7 protein

1

0

High-throughput

0.249

Low

1353442

SAM50
Sorting and assembly machinery component 50 homolog

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025