HitPredict

Interactor 1: TNR6C (Q3UHC0)
Trinucleotide repeat-containing gene 6C protein
Gene: Tnrc6c

Interactor 2: AGO2 (Q8CJG0)
Protein argonaute-2 (Argonaute2) (mAgo2) (EC 3.1.26.n2) (Argonaute RISC catalytic component 2) (Eukaryotic translation initiation factor 2C 2) (eIF-2C 2) (eIF2C 2) (Piwi/argonaute family protein meIF2C2) (Protein slicer)
Gene: AGO2

Species: Mus musculus

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.54	0.60	0.571

Property	Details
Experiments	19838187, 22918229
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000932 - P-body GO:0003723 - RNA binding GO:0005829 - cytosol GO:0060213 - positive regulation of nuclear-transcribed mRNA poly(A) tail shortening GO:1900153 - positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 1690 Mm			1 860
+	Hs
		1336208 TNR6C_HUMAN (1-1690): 0: 843: 88.47		AGO2_HUMAN (21-860): 0: 1193: 99.88
+	Hs
		1336210 TNR6C_HUMAN (1-1690): 0: 843: 88.47		AGO1_HUMAN (18-860): 0: 1173: 83.16
+	Hs
		1334274 TNR6C_HUMAN (1-1690): 0: 843: 88.47		AGO3_HUMAN (17-860): 0: 1155: 80.07
+	Hs
		1336198 TNR6C_HUMAN (1-1690): 0: 843: 88.47		AGO4_HUMAN (13-860): 0: 1136: 78.14
+	Mm
		1112703 TNR6A_MOUSE (2-1687): 3.81e-156: 526: 35.37		AGO2_MOUSE (1-860): 0: 1216: 100.00
+	Hs
		1242690 TNR6A_HUMAN (14-1687): 3.97e-161: 541: 37.58		AGO2_HUMAN (21-860): 0: 1193: 99.88
+	Hs
		1242692 TNR6A_HUMAN (14-1687): 3.97e-161: 541: 37.58		AGO1_HUMAN (18-860): 0: 1173: 83.16
+	Hs
		1242656 TNR6A_HUMAN (14-1687): 3.97e-161: 541: 37.58		AGO3_HUMAN (17-860): 0: 1155: 80.07
+	Mm
		1206838 TNR6B_MOUSE (10-1674): 2.6e-140: 479: 30.75		AGO2_MOUSE (1-860): 0: 1216: 100.00
+	Hs
		1356626 TNR6B_HUMAN (10-1674): 4.42e-148: 502: 32.75		AGO2_HUMAN (21-860): 0: 1193: 99.88
+	Hs
		1242663 TNR6A_HUMAN (14-1687): 3.97e-161: 541: 37.58		AGO4_HUMAN (13-860): 0: 1136: 78.14
+	Hs
		1356716 TNR6B_HUMAN (10-1674): 4.42e-148: 502: 32.75		AGO1_HUMAN (18-860): 0: 1173: 83.16
+	Hs
		1334290 TNR6B_HUMAN (10-1674): 4.42e-148: 502: 32.75		AGO3_HUMAN (17-860): 0: 1155: 80.07
+	Hs
		1336289 TNR6B_HUMAN (10-1674): 4.42e-148: 502: 32.75		AGO4_HUMAN (13-860): 0: 1136: 78.14
+	Dm
		1103823 GAWKY_DROME (442-1601): 1.96e-65: 247: 19.70		Q32KD4_DROME (4-860): 0: 1129: 72.97
+	Dm
		1182892 GAWKY_DROME (442-1601): 1.96e-65: 247: 19.70		Q7KY08_DROME (4-860): 0: 1127: 72.97
+	At
		1125379 NRPE1_ARATH (127-573): 7.22e-47: 187: 14.59		AGO4_ARATH (11-859): 0: 878: 30.67
+	At
		98377 RDM3_ARATH (290-1163): 1.34e-17: 91.9: 11.10		AGO4_ARATH (11-859): 0: 878: 30.67