Protein: PAPD1
Poly(A) RNA polymerase, mitochondrial (PAP) (EC 2.7.7.19) (PAP-associated domain-containing protein 1) (Polynucleotide adenylyltransferase) (Terminal uridylyltransferase 1) (TUTase 1) (mtPAP)

Gene: PAPD1, MTPAP
Organism: Homo sapiens
Interactions: 155
UniProt ID: Q9NVV4

Gene Ontology (top 5):
GO:0000287 - magnesium ion binding
GO:0000965 - mitochondrial RNA 3'-end processing
GO:0002134 - UTP binding
GO:0003723 - RNA binding
GO:0005524 - ATP binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1087586

GRSF1
G-rich sequence factor 1

3

9

Small-scale

0.827

High

1095820

CACO2
Calcium-binding and coiled-coil domain-containing protein 2

5

2

Small-scale

0.729

High

1450865

PAPD1
Poly(A) RNA polymerase, mitochondrial

1

3

Small-scale

0.716

High

991734

DYL1
Dynein light chain 1, cytoplasmic

3

1

High-throughput

0.675

High

1390729

DYL2
Dynein light chain 2, cytoplasmic

4

1

High-throughput

0.630

High

1060922

LRP1
Prolow-density lipoprotein receptor-related protein 1

2

1

High-throughput

0.628

High

620617

NUCL
Nucleolin

1

4

High-throughput

0.618

High

1428745

SLIRP
SRA stem-loop-interacting RNA-binding protein, mitochondrial

1

4

High-throughput

0.618

High

139418

VMA5A
von Willebrand factor A domain-containing protein 5A

2

0

High-throughput

0.602

High

946536

YBEY
Endoribonuclease YbeY

2

0

High-throughput

0.602

High

1450870

TBK1
Serine/threonine-protein kinase TBK1

1

1

High-throughput

0.586

High

243096

PRKN
E3 ubiquitin-protein ligase parkin

2

2

High-throughput

0.584

High

1252533

LN28B
Protein lin-28 homolog B

1

10

High-throughput

0.575

High

1437361

LN28A
Protein lin-28 homolog A

1

10

High-throughput

0.575

High

1450883

EMIL1
EMILIN-1

2

1

High-throughput

0.574

High

397057

ESR1
Estrogen receptor

2

4

High-throughput

0.571

High

279946

CISY
Citrate synthase, mitochondrial

2

0

High-throughput

0.559

High

1162588

CLPP
ATP-dependent Clp protease proteolytic subunit, mitochondrial

2

0

High-throughput

0.559

High

868779

LEG7
Galectin-7

2

1

High-throughput

0.558

High

1123453

ICT1
Large ribosomal subunit protein mL62

2

0

High-throughput

0.547

High

208398

RRP8
Ribosomal RNA-processing protein 8

1

2

High-throughput

0.536

High

287162

PRKRA
Interferon-inducible double-stranded RNA-dependent protein kinase activator A

1

9

High-throughput

0.536

High

290759

SURF6
Surfeit locus protein 6

1

2

High-throughput

0.536

High

447499

NPM
Nucleophosmin

1

3

High-throughput

0.536

High

694020

RL10
Large ribosomal subunit protein uL16

1

1

High-throughput

0.536

High

1152266

MARE1
Microtubule-associated protein RP/EB family member 1

1

1

High-throughput

0.536

High

1396935

ANM6
Protein arginine N-methyltransferase 6

1

1

High-throughput

0.536

High

1450874

HECD1
E3 ubiquitin-protein ligase HECTD1

2

4

Small-scale

0.533

High

289822

MTU1
Mitochondrial tRNA-specific 2-thiouridylase 1

1

0

High-throughput

0.513

High

1155044

ADIPO
Adiponectin

1

0

High-throughput

0.513

High

1242643

FAHD1
Oxaloacetate tautomerase FAHD1, mitochondrial

1

0

High-throughput

0.513

High

1350902

HUMMR
Protein MGARP

1

0

High-throughput

0.513

High

1436074

GEMI7
Gem-associated protein 7

1

0

High-throughput

0.513

High

1436400

PAAT
ATPase PAAT

1

0

High-throughput

0.513

High

1450876

LAMP3
Lysosome-associated membrane glycoprotein 3

1

0

High-throughput

0.513

High

1450879

SYYM
Tyrosine--tRNA ligase, mitochondrial

1

0

High-throughput

0.513

High

1450881

HEY1
Hairy/enhancer-of-split related with YRPW motif protein 1

1

0

High-throughput

0.513

High

1450882

EID1
EP300-interacting inhibitor of differentiation 1

1

0

High-throughput

0.513

High

839834

EPS15
Epidermal growth factor receptor substrate 15

1

2

High-throughput

0.501

High

1450871

GT2D1
General transcription factor II-I repeat domain-containing protein 1

1

0

High-throughput

0.493

High

127403

LEG8
Galectin-8

1

1

High-throughput

0.489

High

221973

FOXS1
Forkhead box protein S1

1

1

High-throughput

0.489

High

317377

ACL6B
Actin-like protein 6B

1

1

High-throughput

0.489

High

505660

DC8L2
DDB1- and CUL4-associated factor 8-like protein 2

1

4

High-throughput

0.489

High

1253579

FOXI2
Forkhead box protein I2

1

1

High-throughput

0.489

High

889509

CLK1
Dual specificity protein kinase CLK1

1

2

High-throughput

0.481

High

138881

STK25
Serine/threonine-protein kinase 25

1

1

High-throughput

0.479

High

287394

RF1M
Peptide chain release factor 1, mitochondrial

1

2

High-throughput

0.479

High

294412

CD123
Translation initiation factor eIF2 assembly protein

1

1

High-throughput

0.479

High

351017

TRUB2
Pseudouridylate synthase TRUB2, mitochondrial

1

1

High-throughput

0.479

High

373288

MYC
Myc proto-oncogene protein

1

4

High-throughput

0.479

High

401576

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

1

High-throughput

0.479

High

471282

ODPA
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial

1

2

High-throughput

0.479

High

589842

RFA2
Replication protein A 32 kDa subunit

1

2

High-throughput

0.479

High

634661

LMNB1
Lamin-B1

1

7

High-throughput

0.479

High

696663

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

1

High-throughput

0.479

High

831519

CCNF
Cyclin-F

1

2

High-throughput

0.479

High

856404

IF2M
Translation initiation factor IF-2, mitochondrial

1

1

High-throughput

0.479

High

872799

SOX2
Transcription factor SOX-2

1

3

High-throughput

0.479

High

879524

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

1

High-throughput

0.479

High

1005156

RNF4
E3 ubiquitin-protein ligase RNF4

1

1

High-throughput

0.479

High

1024874

VIGLN
Vigilin

1

6

High-throughput

0.479

High

1051070

FAK1
Focal adhesion kinase 1

1

4

High-throughput

0.479

High

1090568

TRAP1
Heat shock protein 75 kDa, mitochondrial

1

1

High-throughput

0.479

High

1100448

TIF1B
Transcription intermediary factor 1-beta

1

2

High-throughput

0.479

High

1114436

CUL3
Cullin-3

1

6

High-throughput

0.479

High

1146484

KS6A2
Ribosomal protein S6 kinase alpha-2

1

2

High-throughput

0.479

High

1148398

KS6A1
Ribosomal protein S6 kinase alpha-1

1

2

High-throughput

0.479

High

1271577

DHX30
ATP-dependent RNA helicase DHX30

1

2

High-throughput

0.479

High

1273014

FAKD5
FAST kinase domain-containing protein 5, mitochondrial

1

2

High-throughput

0.479

High

1326361

NIN
Ninein

1

1

High-throughput

0.479

High

1367404

ESR2
Estrogen receptor beta

1

4

High-throughput

0.479

High

1381748

FAKD4
FAST kinase domain-containing protein 4

1

2

High-throughput

0.479

High

1386600

OPTN
Optineurin

1

3

High-throughput

0.479

High

1401639

EFGM
Elongation factor G, mitochondrial

1

1

High-throughput

0.479

High

1432634

MTRFR
Mitochondrial translation release factor in rescue

1

2

High-throughput

0.479

High

1433449

Q9H4D1
Receptor-interacting serine/threonine-protein kinase 4

1

1

High-throughput

0.479

High

1447332

ANLN
Anillin

1

2

High-throughput

0.479

High

1450866

FAKD2
FAST kinase domain-containing protein 2, mitochondrial

1

2

High-throughput

0.479

High

1450868

RF1ML
Peptide chain release factor 1-like, mitochondrial

1

2

High-throughput

0.479

High

1450869

ZRAN1
Ubiquitin thioesterase ZRANB1

1

2

High-throughput

0.479

High

1450872

HOOK1
Protein Hook homolog 1

1

1

High-throughput

0.479

High

61658

VWA8
von Willebrand factor A domain-containing protein 8

1

0

High-throughput

0.458

High

183754

RT12
Small ribosomal subunit protein uS12m

1

0

High-throughput

0.458

High

194365

R113A
E3 ubiquitin-protein ligase RNF113A

1

0

High-throughput

0.458

High

519250

COX8A
Cytochrome c oxidase subunit 8A, mitochondrial

1

0

High-throughput

0.458

High

626374

NFKB1
Nuclear factor NF-kappa-B p105 subunit

1

0

High-throughput

0.458

High

841986

LPPRC
Leucine-rich PPR motif-containing protein, mitochondrial

1

0

High-throughput

0.458

High

852056

EFTS
Elongation factor Ts, mitochondrial

1

0

High-throughput

0.458

High

941978

PEX3
Peroxisomal biogenesis factor 3

1

0

High-throughput

0.458

High

1024207

TFAM
Transcription factor A, mitochondrial

1

0

High-throughput

0.458

High

1048727

SSBP
Single-stranded DNA-binding protein, mitochondrial

1

0

High-throughput

0.458

High

1207164

SYAM
Alanine--tRNA ligase, mitochondrial

1

0

High-throughput

0.458

High

1290764

ZCH18
Zinc finger CCCH domain-containing protein 18

1

0

High-throughput

0.458

High

1388291

RRFM
Ribosome-recycling factor, mitochondrial

1

0

High-throughput

0.458

High

1388431

MTEF3
Transcription termination factor 3, mitochondrial

1

0

High-throughput

0.458

High

1400827

TEFM
Transcription elongation factor, mitochondrial

1

0

High-throughput

0.458

High

1403451

IMP2L
Mitochondrial inner membrane protease subunit 2

1

0

High-throughput

0.458

High

1431977

IF3M
Translation initiation factor IF-3, mitochondrial

1

0

High-throughput

0.458

High

1432320

PARL
Presenilin-associated rhomboid-like protein, mitochondrial

1

0

High-throughput

0.458

High

1435807

MET17
Ribosome assembly protein METTL17, mitochondrial

1

0

High-throughput

0.458

High

1450867

MRES1
Mitochondrial transcription rescue factor 1

1

0

High-throughput

0.458

High

1450875

DIM1
Dimethyladenosine transferase

1

0

High-throughput

0.458

High

1450880

RM11
Large ribosomal subunit protein uL11m

1

0

High-throughput

0.458

High

430423

JUN
Transcription factor Jun

1

1

High-throughput

0.445

High

944080

RIPK4
Receptor-interacting serine/threonine-protein kinase 4

1

1

High-throughput

0.445

High

126828

RHOD
Rho-related GTP-binding protein RhoD

1

6

High-throughput

0.437

High

132337

WWP2
NEDD4-like E3 ubiquitin-protein ligase WWP2

1

2

High-throughput

0.437

High

174623

TRI66
Tripartite motif-containing protein 66

1

2

High-throughput

0.437

High

272497

OBSL1
Obscurin-like protein 1

1

1

High-throughput

0.437

High

342339

BRD1
Bromodomain-containing protein 1

1

3

High-throughput

0.437

High

581325

RAC2
Ras-related C3 botulinum toxin substrate 2

1

3

High-throughput

0.437

High

767356

MERL
Merlin

1

1

High-throughput

0.437

High

910221

RND2
Rho-related GTP-binding protein RhoN

1

5

High-throughput

0.437

High

955665

CDC42
Cell division control protein 42 homolog

1

4

High-throughput

0.437

High

962550

RHOA
Transforming protein RhoA

1

4

High-throughput

0.437

High

1015840

RHOG
Rho-related GTP-binding protein RhoG

1

3

High-throughput

0.437

High

1151901

RHOH
Rho-related GTP-binding protein RhoH

1

4

High-throughput

0.437

High

1220842

RN123
E3 ubiquitin-protein ligase RNF123

1

1

High-throughput

0.437

High

1227561

A16L1
Autophagy-related protein 16-1

1

5

High-throughput

0.437

High

1255785

TRI67
Tripartite motif-containing protein 67

1

3

High-throughput

0.437

High

1276862

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

2

High-throughput

0.437

High

1291590

HOOK3
Protein Hook homolog 3

1

1

High-throughput

0.437

High

1325529

FBXW8
F-box/WD repeat-containing protein 8

1

2

High-throughput

0.437

High

1433535

RHOJ
Rho-related GTP-binding protein RhoJ

1

4

High-throughput

0.437

High

1434038

PKHA4
Pleckstrin homology domain-containing family A member 4

1

3

High-throughput

0.437

High

1438185

RHOF
Rho-related GTP-binding protein RhoF

1

5

High-throughput

0.437

High

1450878

NINL
Ninein-like protein

1

1

High-throughput

0.437

High

653606

HEMH
Ferrochelatase, mitochondrial

1

0

High-throughput

0.426

High

1239961

CAVN1
Caveolae-associated protein 1

1

0

High-throughput

0.426

High

1450873

PNMA2
Paraneoplastic antigen Ma2

1

1

High-throughput

0.407

High

888485

TSP3
Thrombospondin-3

3

0

High-throughput

0.347

High

549899

CD79A
B-cell antigen receptor complex-associated protein alpha chain

2

0

High-throughput

0.328

High

1435142

AZI2
5-azacytidine-induced protein 2

1

0

High-throughput

0.301

High

182804

GP182
G-protein coupled receptor 182

1

0

High-throughput

0.279

Low

192751

ARPC5
Actin-related protein 2/3 complex subunit 5

1

0

High-throughput

0.279

Low

692823

CALL3
Calmodulin-like protein 3

1

0

High-throughput

0.279

Low

1324875

LRC25
Leucine-rich repeat-containing protein 25

1

0

High-throughput

0.279

Low

1330836

TSYL6
Testis-specific Y-encoded-like protein 6

1

0

High-throughput

0.279

Low

1337524

DDHD1
Phospholipase DDHD1

1

0

High-throughput

0.279

Low

1349134

F174A
Membrane protein FAM174A

1

0

High-throughput

0.279

Low

1361655

ATG4A
Cysteine protease ATG4A

1

0

High-throughput

0.279

Low

1395174

ZN333
Zinc finger protein 333

1

0

High-throughput

0.279

Low

1450877

VSIG4
V-set and immunoglobulin domain-containing protein 4

1

0

High-throughput

0.279

Low

1397924

DMRTB
Doublesex- and mab-3-related transcription factor B1

1

0

High-throughput

0.251

Low

377748

INS
Insulin [Cleaved into: Insulin B chain; Insulin A chain]

1

0

High-throughput

0.249

Low

991943

DYLT1
Dynein light chain Tctex-type 1

1

0

High-throughput

0.249

Low

1178420

CL16A
Protein CLEC16A

1

0

High-throughput

0.249

Low

1393753

DDRGK
DDRGK domain-containing protein 1

1

0

High-throughput

0.249

Low

1438446

SACA1
Sperm acrosome membrane-associated protein 1

1

0

High-throughput

0.249

Low

2123

TVA20
T cell receptor alpha variable 20

1

0

High-throughput

0.232

Low

848082

AL3B1
Aldehyde dehydrogenase family 3 member B1

1

0

High-throughput

0.232

Low

1197894

S39AC
Zinc transporter ZIP12

1

0

High-throughput

0.232

Low

1206687

LRC73
Leucine-rich repeat-containing protein 73

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025