HitPredict

Interactor 1: CUL3 (Q13618)
Cullin-3 (CUL-3)
Gene: CUL3

Interactor 2: TMTC2 (Q8N394)
Protein O-mannosyl-transferase TMTC2 (EC 2.4.1.109) (Transmembrane O-mannosyltransferase targeting cadherins 2) (Transmembrane and tetratricopeptide repeat-containing 2)
Gene: TMTC2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.80	0.618

Property	Details
Experiments	21145461
Identification Methods	affinity chromatography technology, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Cullin~TPR_12
Common GO terms	-
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 768 Hs			1 836
+	Hs
		1114071 CUL3_HUMAN (1-768): 0: 943: 100.00		BBS4_HUMAN (433-805): 4.08e-35: 142: 17.55
+	Hs
		194561 CUL3_HUMAN (1-768): 0: 943: 100.00		KDM6A_HUMAN (441-783): 1.37e-30: 132: 13.76
+	Hs
		185678 CUL3_HUMAN (1-768): 0: 943: 100.00		OGT1_HUMAN (646-835): 4.4e-29: 126: 24.21
+	Hs
		1113532 CUL3_HUMAN (1-768): 0: 943: 100.00		NPHP3_HUMAN (575-828): 1.63e-18: 93.3: 16.25
+	Hs
		1114101 CUL3_HUMAN (1-768): 0: 943: 100.00		DNJC7_HUMAN (711-835): 1.26e-17: 88.7: 16.80
+	Hs
		1113556 CUL3_HUMAN (1-768): 0: 943: 100.00		TTC7B_HUMAN (424-568): 1.9e-11: 69.9: 13.61
+	Hs
		194562 CUL4B_HUMAN (5-768): 0: 796: 36.77		KDM6A_HUMAN (441-783): 1.37e-30: 132: 13.76
+	Hs
		185679 CUL4B_HUMAN (5-768): 0: 796: 36.77		OGT1_HUMAN (646-835): 4.4e-29: 126: 24.21
+	Hs
		731271 CUL4B_HUMAN (5-768): 0: 796: 36.77		STIP1_HUMAN (307-612): 8.34e-17: 86.4: 10.82
+	Hs
		194560 CUL1_HUMAN (18-768): 0: 709: 30.57		KDM6A_HUMAN (441-783): 1.37e-30: 132: 13.76
+	Hs
		731270 CUL1_HUMAN (18-768): 0: 709: 30.57		STIP1_HUMAN (307-612): 8.34e-17: 86.4: 10.82