Protein: KDM6A
Lysine-specific demethylase 6A (EC 1.14.11.68) (Histone demethylase UTX) (Ubiquitously-transcribed TPR protein on the X chromosome) (Ubiquitously-transcribed X chromosome tetratricopeptide repeat protein) ([histone H3]-trimethyl-L-lysine(27) demethylase 6A)

Gene: KDM6A
Organism: Homo sapiens
Interactions: 160
UniProt ID: O15550

Gene Ontology (top 5):
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0006338 - chromatin remodeling
GO:0007507 - heart development

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

161374

KMT2D
Histone-lysine N-methyltransferase 2D

6

20

Small-scale

0.935

High

194588

KMT2C
Histone-lysine N-methyltransferase 2C

3

20

Small-scale

0.847

High

194623

ASH2L
Set1/Ash2 histone methyltransferase complex subunit ASH2

12

7

Small-scale

0.755

High

194567

RBBP5
Retinoblastoma-binding protein 5

10

19

Small-scale

0.752

High

194540

WDR5
WD repeat-containing protein 5

9

13

Small-scale

0.752

High

194564

NCOA6
Nuclear receptor coactivator 6

6

14

Small-scale

0.730

High

194576

PAXI1
PAX-interacting protein 1

6

13

Small-scale

0.729

High

194606

PAGR1
PAXIP1-associated glutamate-rich protein 1

5

1

Small-scale

0.709

High

194499

ANDR
Androgen receptor

4

20

Small-scale

0.686

High

194608

DPY30
Protein dpy-30 homolog

3

2

Small-scale

0.650

High

194525

SOX2
Transcription factor SOX-2

3

16

Small-scale

0.640

High

194598

FBXW7
F-box/WD repeat-containing protein 7

3

16

Small-scale

0.633

High

185261

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

1

15

Small-scale

0.618

High

194485

KDM6A
Lysine-specific demethylase 6A

1

14

High-throughput

0.618

High

194541

H4
Histone H4

1

4

High-throughput

0.618

High

194551

KMT2A
Histone-lysine N-methyltransferase 2A

1

20

High-throughput

0.618

High

194615

CSR2B
Cysteine-rich protein 2-binding protein

1

6

High-throughput

0.618

High

194620

CXXC1
CXXC-type zinc finger protein 1

1

11

High-throughput

0.618

High

194629

KMT2B
Histone-lysine N-methyltransferase 2B

1

20

High-throughput

0.618

High

194582

RHG22
Rho GTPase-activating protein 22

2

8

High-throughput

0.611

High

192349

GSC2
Homeobox protein goosecoid-2

2

7

High-throughput

0.606

High

194544

H31
Histone H3.1

2

10

Small-scale

0.602

High

194557

NFIA
Nuclear factor 1 A-type

2

11

High-throughput

0.601

High

194565

NFIX
Nuclear factor 1 X-type

2

10

High-throughput

0.601

High

142726

NFIB
Nuclear factor 1 B-type

2

5

High-throughput

0.584

High

194488

KLF4
Krueppel-like factor 4

2

13

Small-scale

0.584

High

194498

NFIC
Nuclear factor 1 C-type

2

10

High-throughput

0.584

High

194539

KLF3
Krueppel-like factor 3

2

14

High-throughput

0.584

High

194575

WDR82
WD repeat-containing protein 82

2

20

Small-scale

0.584

High

194533

NKX25
Homeobox protein Nkx-2.5

1

7

Small-scale

0.552

High

194603

TBX5
T-box transcription factor TBX5

1

3

Small-scale

0.552

High

194593

RSPH1
Radial spoke head 1 homolog

1

4

High-throughput

0.541

High

194497

TRY1
Serine protease 1

1

4

High-throughput

0.536

High

194600

DYL2
Dynein light chain 2, cytoplasmic

1

3

High-throughput

0.536

High

194503

SRF
Serum response factor

1

0

Small-scale

0.529

High

194574

Q6FHY5
MEOX2 protein

1

3

High-throughput

0.515

High

181835

SMAD9
Mothers against decapentaplegic homolog 9

1

11

High-throughput

0.508

High

194572

H31T
Histone H3.1t

1

10

Small-scale

0.501

High

194577

H32
Histone H3.2

1

10

Small-scale

0.501

High

194611

TSYL2
Testis-specific Y-encoded-like protein 2

1

5

Small-scale

0.501

High

194538

HUNK
Hormonally up-regulated neu tumor-associated kinase

1

3

High-throughput

0.494

High

194493

BAG2
BAG family molecular chaperone regulator 2

1

1

High-throughput

0.489

High

194514

S10A2
Protein S100-A2

1

2

High-throughput

0.489

High

194543

TBA1B
Tubulin alpha-1B chain

1

10

High-throughput

0.489

High

194529

MEOX2
Homeobox protein MOX-2

1

4

High-throughput

0.481

High

194552

TLE1
Transducin-like enhancer protein 1

1

18

Small-scale

0.481

High

194596

CBP
CREB-binding protein

1

16

Small-scale

0.481

High

124557

EYA2
Protein phosphatase EYA2

1

8

High-throughput

0.479

High

128631

MEN1
Menin

1

3

High-throughput

0.479

High

175811

SET1A
Histone-lysine N-methyltransferase SETD1A

1

20

High-throughput

0.479

High

181477

TBXT
T-box transcription factor T

1

3

High-throughput

0.479

High

194486

SERA
D-3-phosphoglycerate dehydrogenase

1

4

Small-scale

0.479

High

194487

CRX
Cone-rod homeobox protein

1

9

High-throughput

0.479

High

194489

BUB3
Mitotic checkpoint protein BUB3

1

16

High-throughput

0.479

High

194490

TLX3
T-cell leukemia homeobox protein 3

1

6

High-throughput

0.479

High

194491

SOX15
Transcription factor SOX-15

1

15

High-throughput

0.479

High

194492

BRD4
Bromodomain-containing protein 4

1

13

High-throughput

0.479

High

194494

FOS
Protein c-Fos

1

5

High-throughput

0.479

High

194495

GCR
Glucocorticoid receptor

1

20

High-throughput

0.479

High

194496

P53
Cellular tumor antigen p53

1

7

Small-scale

0.479

High

194501

EGR2
E3 SUMO-protein ligase EGR2

1

5

High-throughput

0.479

High

194502

ERG
Transcriptional regulator ERG

1

7

High-throughput

0.479

High

194504

ETS1
Protein C-ets-1

1

7

High-throughput

0.479

High

194505

MYOD1
Myoblast determination protein 1

1

3

High-throughput

0.479

High

194506

GATA1
Erythroid transcription factor

1

7

High-throughput

0.479

High

194507

TFE3
Transcription factor E3

1

3

Small-scale

0.479

High

194508

HNF1A
Hepatocyte nuclear factor 1-alpha

1

1

High-throughput

0.479

High

194509

PAX7
Paired box protein Pax-7

1

9

High-throughput

0.479

High

194510

GATA2
Endothelial transcription factor GATA-2

1

7

High-throughput

0.479

High

194511

GATA3
Trans-acting T-cell-specific transcription factor GATA-3

1

7

High-throughput

0.479

High

194512

PAX6
Paired box protein Pax-6

1

8

High-throughput

0.479

High

194513

TEAD1
Transcriptional enhancer factor TEF-1

1

1

High-throughput

0.479

High

194515

TLX1
T-cell leukemia homeobox protein 1

1

7

High-throughput

0.479

High

194516

HNF1B
Hepatocyte nuclear factor 1-beta

1

10

High-throughput

0.479

High

194517

PPARG
Peroxisome proliferator-activated receptor gamma

1

20

High-throughput

0.479

High

194518

ETV5
ETS translocation variant 5

1

8

High-throughput

0.479

High

194519

HNF4A
Hepatocyte nuclear factor 4-alpha

1

19

High-throughput

0.479

High

194520

ELK3
ETS domain-containing protein Elk-3

1

8

High-throughput

0.479

High

194522

ETV4
ETS translocation variant 4

1

8

High-throughput

0.479

High

194523

GATA4
Transcription factor GATA-4

1

7

Small-scale

0.479

High

194524

YAP1
Transcriptional coactivator YAP1

1

18

High-throughput

0.479

High

194526

SOX9
Transcription factor SOX-9

1

15

High-throughput

0.479

High

194527

LHX1
LIM/homeobox protein Lhx1

1

5

High-throughput

0.479

High

194528

CEBPA
CCAAT/enhancer-binding protein alpha

1

9

High-throughput

0.479

High

194530

LHX2
LIM/homeobox protein Lhx2

1

7

High-throughput

0.479

High

194531

SMCA4
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4

1

8

Small-scale

0.479

High

194532

HCFC1
Host cell factor 1

1

4

High-throughput

0.479

High

194534

FOXA1
Hepatocyte nuclear factor 3-alpha

1

7

High-throughput

0.479

High

194535

PAX9
Paired box protein Pax-9

1

8

High-throughput

0.479

High

194536

SOX10
Transcription factor SOX-10

1

19

High-throughput

0.479

High

194537

GSC
Homeobox protein goosecoid

1

7

High-throughput

0.479

High

194542

RBX1
E3 ubiquitin-protein ligase RBX1

1

5

Small-scale

0.479

High

194545

FOXK1
Forkhead box protein K1

1

7

Small-scale

0.479

High

194546

FOXK2
Forkhead box protein K2

1

9

Small-scale

0.479

High

194547

PO5F1
POU domain, class 5, transcription factor 1

1

9

Small-scale

0.479

High

194548

IRF8
Interferon regulatory factor 8

1

4

High-throughput

0.479

High

194549

HEN1
Helix-loop-helix protein 1

1

5

High-throughput

0.479

High

194550

PAX2
Paired box protein Pax-2

1

8

High-throughput

0.479

High

194553

HME1
Homeobox protein engrailed-1

1

4

High-throughput

0.479

High

194554

PAX8
Paired box protein Pax-8

1

9

High-throughput

0.479

High

194555

PRDX1
Peroxiredoxin-1

1

1

High-throughput

0.479

High

194558

FOXI1
Forkhead box protein I1

1

6

High-throughput

0.479

High

194559

FOXL1
Forkhead box protein L1

1

6

High-throughput

0.479

High

194560

CUL1
Cullin-1

1

9

Small-scale

0.479

High

194561

CUL3
Cullin-3

1

9

High-throughput

0.479

High

194562

CUL4B
Cullin-4B

1

9

Small-scale

0.479

High

194563

KLF5
Krueppel-like factor 5

1

14

High-throughput

0.479

High

194566

SUZ12
Polycomb protein SUZ12

1

1

High-throughput

0.479

High

194568

IRF4
Interferon regulatory factor 4

1

4

High-throughput

0.479

High

194569

EZH2
Histone-lysine N-methyltransferase EZH2

1

16

High-throughput

0.479

High

194570

DDB1
DNA damage-binding protein 1

1

1

Small-scale

0.479

High

194571

TBR1
T-box brain protein 1

1

3

High-throughput

0.479

High

194573

PP6R3
Serine/threonine-protein phosphatase 6 regulatory subunit 3

1

1

Small-scale

0.479

High

194578

ASXL2
Putative Polycomb group protein ASXL2

1

15

Small-scale

0.479

High

194579

DET1
DET1 homolog

1

2

Small-scale

0.479

High

194580

KANL1
KAT8 regulatory NSL complex subunit 1

1

1

High-throughput

0.479

High

194581

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

5

High-throughput

0.479

High

194585

ASXL1
Polycomb group protein ASXL1

1

5

Small-scale

0.479

High

194589

BD1L1
Biorientation of chromosomes in cell division protein 1-like 1

1

2

High-throughput

0.479

High

194590

MAFA
Transcription factor MafA

1

4

Small-scale

0.479

High

194591

COP1
E3 ubiquitin-protein ligase COP1

1

18

Small-scale

0.479

High

194592

SP7
Transcription factor Sp7

1

8

High-throughput

0.479

High

194594

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

5

Small-scale

0.479

High

194595

ESR2
Estrogen receptor beta

1

20

High-throughput

0.479

High

194597

LHX4
LIM/homeobox protein Lhx4

1

5

High-throughput

0.479

High

194599

MCRS1
Microspherule protein 1

1

1

High-throughput

0.479

High

194601

RING2
E3 ubiquitin-protein ligase RING2

1

17

Small-scale

0.479

High

194602

FEV
Protein FEV

1

7

High-throughput

0.479

High

194604

ELF4
ETS-related transcription factor Elf-4

1

8

High-throughput

0.479

High

194605

SOX7
Transcription factor SOX-7

1

14

High-throughput

0.479

High

194607

KLF16
Krueppel-like factor 16

1

9

High-throughput

0.479

High

194610

WWTR1
WW domain-containing transcription regulator protein 1

1

14

High-throughput

0.479

High

194613

SOX17
Transcription factor SOX-17

1

17

High-throughput

0.479

High

194614

KAT8
Histone acetyltransferase KAT8

1

3

High-throughput

0.479

High

194616

KANL2
KAT8 regulatory NSL complex subunit 2

1

1

High-throughput

0.479

High

194618

MBIP1
MAP3K12-binding inhibitory protein 1

1

1

High-throughput

0.479

High

194621

KANL3
KAT8 regulatory NSL complex subunit 3

1

1

High-throughput

0.479

High

194622

RERE
Arginine-glutamic acid dipeptide repeats protein

1

7

High-throughput

0.479

High

194624

LHX3
LIM/homeobox protein Lhx3

1

4

High-throughput

0.479

High

194625

KLF15
Krueppel-like factor 15

1

10

High-throughput

0.479

High

194626

SIX4
Homeobox protein SIX4

1

4

Small-scale

0.479

High

194627

ELF5
ETS-related transcription factor Elf-5

1

7

High-throughput

0.479

High

194628

YETS2
YEATS domain-containing protein 2

1

12

High-throughput

0.479

High

194630

SET1B
Histone-lysine N-methyltransferase SETD1B

1

20

High-throughput

0.479

High

194631

ZN281
Zinc finger protein 281

1

4

Small-scale

0.479

High

194632

RN114
E3 ubiquitin-protein ligase RNF114

1

6

Small-scale

0.479

High

194633

MAFB
Transcription factor MafB

1

5

Small-scale

0.479

High

194634

HCFC2
Host cell factor 2

1

6

High-throughput

0.479

High

194586

ZZZ3
ZZ-type zinc finger-containing protein 3

1

0

High-throughput

0.458

High

194617

GCM1
Chorion-specific transcription factor GCMa

1

0

High-throughput

0.458

High

194500

TAU
Microtubule-associated protein tau

1

10

High-throughput

0.445

High

194521

MATR3
Matrin-3

1

6

Small-scale

0.445

High

194619

GRHL1
Grainyhead-like protein 1 homolog

1

2

High-throughput

0.445

High

194556

GOGA2
Golgin subfamily A member 2

1

4

High-throughput

0.437

High

194584

PRSR1
Proline and serine-rich protein 1

1

12

Small-scale

0.437

High

194609

ASXL3
Putative Polycomb group protein ASXL3

1

9

Small-scale

0.437

High

194612

PKHA4
Pleckstrin homology domain-containing family A member 4

1

15

High-throughput

0.437

High

194587

CF107
Cilia- and flagella-associated protein 107

1

0

High-throughput

0.279

Low

194583

N4BP2
NEDD4-binding protein 2

1

0

Small-scale

0.249

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025