HitPredict

Interactor 1: SHAN3 (Q4ACU6)
SH3 and multiple ankyrin repeat domains protein 3 (Shank3) (Proline-rich synapse-associated protein 2) (ProSAP2) (SPANK-2)
Gene: Shank3

Interactor 2: PCLO (Q9QYX7)
Protein piccolo (Aczonin) (Brain-derived HLMN protein) (Multidomain presynaptic cytomatrix protein)
Gene: PCLO

Species: Mus musculus

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	1.00	0.575

Property	Details
Experiments	29111324
Identification Methods	pull down
Interaction Type	association

Property	Details
Interacting Pfam domains	PDZ~PDZ_6, PDZ~SAM_1, PDZ~SH3_2
Common GO terms	GO:0014069 - postsynaptic density GO:0098978 - glutamatergic synapse
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 1730 Mm			1 5068
+	Mm
		593484 SHAN3_MOUSE (1-1730): 0: 626: 100.00		KPCA_MOUSE (4549-4799): 1.93e-64: 237: 21.40
+	Mm
		292327 SHAN3_MOUSE (1-1730): 0: 626: 100.00		ZAN_MOUSE (2936-3676): 2.29e-37: 159: 9.95
+	Mm
		93248 SHAN3_MOUSE (1-1730): 0: 626: 100.00		E9PWQ7_MOUSE (2969-3676): 4.02e-35: 151: 10.35
+	Mm
		802297 SHAN3_MOUSE (1-1730): 0: 626: 100.00		SYT1_MOUSE (4762-5064): 4.7e-31: 131: 14.97
+	Mm
		1116022 SHAN3_MOUSE (1-1730): 0: 626: 100.00		ANK2_MOUSE (24-2104): 4.59e-21: 105: 10.37
+	Hs
		129086 SHAN3_HUMAN (1-1730): 0: 601: 95.21		SYT5_HUMAN (4923-5064): 5.31e-27: 118: 25.34
+	Mm
		934624 SHAN3_MOUSE (1-1730): 0: 626: 100.00		KPCB_MOUSE (4624-4758): 6.23e-14: 80.9: 36.30
+	Mm
		930566 SHAN3_MOUSE (1-1730): 0: 626: 100.00		KPCG_MOUSE (4624-4758): 4.72e-13: 78.2: 36.96
+	Dm
		65570 A8JNM5_DROME (19-638): 1.13e-74: 279: 14.72		FUTSC_DROME (229-4169): 4.56e-91: 337: 10.93
+	Mm
		103608 ANK3_MOUSE (41-592): 7.79e-85: 311: 15.58		ANK2_MOUSE (24-2104): 4.59e-21: 105: 10.37
+	Hs
		135790 MIB1_HUMAN (187-625): 7.14e-50: 195: 10.66		P3C2B_HUMAN (4466-4759): 6.19e-55: 216: 20.00
+	Hs
		408681 Q9H4D1_HUMAN (1-279): 6.7e-66: 242: 18.21		KPCB_HUMAN (4624-4758): 3.79e-14: 81.6: 36.30
+	Hs
		408584 RIPK4_HUMAN (1-279): 5.68e-65: 240: 18.21		KPCB_HUMAN (4624-4758): 3.79e-14: 81.6: 36.30
+	Hs
		599563 ANK2_HUMAN (212-349): 7.67e-29: 129: 24.64		SYT1_HUMAN (4762-5064): 5.01e-31: 131: 14.97
+	Dm
		113976 M9PB30_DROME (662-1371): 7.2e-27: 122: 15.27		M9PB30_DROME (3318-4065): 2.13e-11: 73.7: 10.40
+	Hs
		1200023 KDIS_HUMAN (258-430): 1.28e-21: 105: 16.19		RIMS1_HUMAN (4773-5067): 8.78e-10: 68: 24.52
+	Hs
		1200041 PCLO_HUMAN (347-1361): 2.55e-17: 91.3: 10.90		RIMS1_HUMAN (4773-5067): 8.78e-10: 68: 24.52