Protein: COQ6
Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial (EC 1.14.15.45) (2-methoxy-6-polyprenolphenol 4-hydroxylase) (EC 1.14.15.46) (Coenzyme Q10 monooxygenase 6)

Gene: COQ6
Organism: Homo sapiens
Interactions: 59
UniProt ID: Q9Y2Z9

Gene Ontology (top 5):
GO:0005739 - mitochondrion
GO:0005743 - mitochondrial inner membrane
GO:0005794 - Golgi apparatus
GO:0006744 - ubiquinone biosynthetic process
GO:0016491 - oxidoreductase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1453378

COQ3
Ubiquinone biosynthesis O-methyltransferase, mitochondrial

3

5

High-throughput

0.664

High

1491015

COQ6
Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial

1

3

High-throughput

0.618

High

1414126

TMM70
Transmembrane protein 70, mitochondrial

2

0

High-throughput

0.602

High

243353

PRKN
E3 ubiquitin-protein ligase parkin

2

1

High-throughput

0.584

High

275139

COQ9
Ubiquinone biosynthesis protein COQ9, mitochondrial

1

1

High-throughput

0.561

High

1205158

COQ5
2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial

1

1

High-throughput

0.561

High

1162630

CLPP
ATP-dependent Clp protease proteolytic subunit, mitochondrial

2

0

High-throughput

0.559

High

1459995

AMACR
Alpha-methylacyl-CoA racemase

1

1

High-throughput

0.536

High

907256

ARSL
Arylsulfatase L

1

0

High-throughput

0.518

High

690577

KAD4
Adenylate kinase 4, mitochondrial

1

0

High-throughput

0.513

High

1242654

FAHD1
Oxaloacetate tautomerase FAHD1, mitochondrial

1

0

High-throughput

0.513

High

1350924

HUMMR
Protein MGARP

1

0

High-throughput

0.513

High

1430319

GATA
Glutamyl-tRNA(Gln) amidotransferase subunit A, mitochondrial

1

0

High-throughput

0.513

High

1051442

ZBT16
Zinc finger and BTB domain-containing protein 16

1

1

High-throughput

0.494

High

1116160

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

1

High-throughput

0.489

High

423498

A4
Amyloid-beta precursor protein

1

0

High-throughput

0.480

High

282133

MPPB
Mitochondrial-processing peptidase subunit beta

1

1

High-throughput

0.479

High

1083803

MPPA
Mitochondrial-processing peptidase subunit alpha

1

1

High-throughput

0.479

High

1090600

TRAP1
Heat shock protein 75 kDa, mitochondrial

1

2

High-throughput

0.479

High

1341352

COQ8A
Atypical kinase COQ8A, mitochondrial

1

2

High-throughput

0.479

High

1387087

COQ8B
Atypical kinase COQ8B, mitochondrial

1

2

High-throughput

0.479

High

1447200

NIT2
Omega-amidase NIT2

1

1

High-throughput

0.479

High

1491016

COQ4
Ubiquinone biosynthesis protein COQ4 homolog, mitochondrial

1

1

High-throughput

0.479

High

348264

DCMC
Malonyl-CoA decarboxylase, mitochondrial

1

0

High-throughput

0.458

High

554863

ODBA
2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial

1

0

High-throughput

0.458

High

568527

ETFA
Electron transfer flavoprotein subunit alpha, mitochondrial

1

0

High-throughput

0.458

High

617623

ATP5J
ATP synthase peripheral stalk subunit F6, mitochondrial

1

0

High-throughput

0.458

High

784769

ATPG
ATP synthase F(1) complex subunit gamma, mitochondrial

1

0

High-throughput

0.458

High

940635

ATP5E
ATP synthase F(1) complex subunit epsilon, mitochondrial

1

0

High-throughput

0.458

High

1023650

CYC
Cytochrome c

1

0

High-throughput

0.458

High

1058363

C1QBP
Complement component 1 Q subcomponent-binding protein, mitochondrial

1

0

High-throughput

0.458

High

1092688

ECH1
Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial

1

0

High-throughput

0.458

High

1200405

BOLA3
BolA-like protein 3

1

0

High-throughput

0.458

High

1216294

NDUF5
Arginine-hydroxylase NDUFAF5, mitochondrial

1

0

High-throughput

0.458

High

1386642

OPTN
Optineurin

1

0

High-throughput

0.458

High

1418170

RM13
Large ribosomal subunit protein uL13m

1

0

High-throughput

0.458

High

1490905

PDIP2
Polymerase delta-interacting protein 2

1

0

High-throughput

0.458

High

1491017

CHCH2
Coiled-coil-helix-coiled-coil-helix domain-containing protein 2

1

0

High-throughput

0.458

High

1246038

ZNT9
Proton-coupled zinc antiporter SLC30A9, mitochondrial

1

2

High-throughput

0.445

High

229588

NRDC
Nardilysin

1

2

High-throughput

0.437

High

373562

MYC
Myc proto-oncogene protein

1

1

High-throughput

0.437

High

1256193

TRI67
Tripartite motif-containing protein 67

1

1

High-throughput

0.437

High

1459393

ZRAN1
Ubiquitin thioesterase ZRANB1

1

1

High-throughput

0.437

High

1227748

A16L1
Autophagy-related protein 16-1

1

1

High-throughput

0.407

High

1419171

S17A9
Voltage-gated purine nucleotide uniporter SLC17A9

1

2

High-throughput

0.407

High

1330845

TSYL6
Testis-specific Y-encoded-like protein 6

2

0

High-throughput

0.328

High

531182

KAP0
cAMP-dependent protein kinase type I-alpha regulatory subunit

2

0

High-throughput

0.298

High

182845

GP182
G-protein coupled receptor 182

1

0

High-throughput

0.279

Low

502601

H2A1
Histone H2A type 1

1

0

High-throughput

0.279

Low

1101450

SG2A2
Mammaglobin-A

1

0

High-throughput

0.279

Low

292482

PALM
Paralemmin-1

1

0

High-throughput

0.269

Low

353637

AGR2
Anterior gradient protein 2 homolog

1

0

High-throughput

0.269

Low

668082

CDK2
Cyclin-dependent kinase 2

1

0

High-throughput

0.249

Low

1434291

PKHA4
Pleckstrin homology domain-containing family A member 4

1

0

High-throughput

0.249

Low

1462479

B9D1
B9 domain-containing protein 1

1

0

High-throughput

0.249

Low

379589

IGHM
Immunoglobulin heavy constant mu

1

0

High-throughput

0.232

Low

775385

FUS
RNA-binding protein FUS

1

0

High-throughput

0.232

Low

1326164

RYBP
RING1 and YY1-binding protein

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025