HitPredict

Interactor 1: DHB12 (Q53GQ0)
Very-long-chain 3-oxoacyl-CoA reductase (EC 1.1.1.330) (17-beta-hydroxysteroid dehydrogenase 12) (17-beta-HSD 12) (3-ketoacyl-CoA reductase) (KAR) (Estradiol 17-beta-dehydrogenase 12) (EC 1.1.1.62) (Short chain dehydrogenase/reductase family 12C member 1)
Gene: HSD17B12

Interactor 2: ESYT1 (Q9BSJ8)
Extended synaptotagmin-1 (E-Syt1) (Membrane-bound C2 domain-containing protein)
Gene: ESYT1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.54	0.60	0.571

Property	Details
Experiments	37931956, 35271311
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005783 - endoplasmic reticulum GO:0005789 - endoplasmic reticulum membrane
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 312 Hs			1 1104
+	Hs
		1240279 DHB11_HUMAN (29-256): 1.18e-62: 202: 29.06		ESYT1_HUMAN (1-1104): 0: 874: 100.00
+	Hs
		1311459 DHRS7_HUMAN (55-232): 4.21e-15: 76.6: 32.43		ESYT1_HUMAN (1-1104): 0: 874: 100.00
+	Hs
		48377 DHB12_HUMAN (1-312): 4.67e-98: 292: 100.00		ESYT2_HUMAN (848-1101): 9e-14: 78.1: 12.32
+	Hs
		48423 DHB11_HUMAN (29-256): 1.18e-62: 202: 29.06		ESYT2_HUMAN (848-1101): 9e-14: 78.1: 12.32
+	Hs
		48388 DRS7B_HUMAN (54-240): 6.84e-16: 78.6: 29.23		ESYT2_HUMAN (848-1101): 9e-14: 78.1: 12.32
+	Hs
		48561 DHRS7_HUMAN (55-232): 4.21e-15: 76.6: 32.43		ESYT2_HUMAN (848-1101): 9e-14: 78.1: 12.32