HitPredict

Interactor 1: ARHG7 (Q14155)
Rho guanine nucleotide exchange factor 7 (Beta-Pix) (COOL-1) (PAK-interacting exchange factor beta) (p85)
Gene: ARHGEF7

Interactor 2: LRRK2 (Q5S007)
Leucine-rich repeat serine/threonine-protein kinase 2 (EC 2.7.11.1) (EC 3.6.5.-) (Dardarin)
Gene: LRRK2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.70 1.00 0.840

The method score is based on:

Property Details
Experiments 21048939, 25500533
Identification Methods affinity chromatography technology, enzymatic study, anti tag coimmunoprecipitation, protein kinase assay
Interaction Type physical association, direct interaction, association, phosphorylation reaction

The annotation score is based on:

Property Details
Interacting Pfam domains PH~Pkinase
Common GO terms GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0007030 - Golgi organization
GO:0007266 - Rho protein signal transduction
GO:0043005 - neuron projection
and 2 others

more...
Homologous interactions 3

Homologous interactions

Color coding for hit scores

1 803
Hs

1 2527
+ Hs
+ Mm
+ Mm

Service provided by Combinatics, Japan

Last updated: 11Aug2025