Protein: LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2 (EC 2.7.11.1) (EC 3.6.5.-)

Gene: LRRK2
Organism: Mus musculus
Interactions: 92
UniProt ID: Q5S006

Gene Ontology (top 5):
GO:0000139 - Golgi membrane
GO:0000287 - magnesium ion binding
GO:0003779 - actin binding
GO:0003924 - GTPase activity
GO:0004672 - protein kinase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1209171

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

5

20

Small-scale

0.923

High

462115

HS90A
Heat shock protein HSP 90-alpha

2

17

Small-scale

0.754

High

958395

ARP2
Actin-related protein 2

2

10

Small-scale

0.737

High

810520

DYN1
Dynamin-1

2

8

Small-scale

0.712

High

953245

ACTB
Actin, cytoplasmic 1

2

10

Small-scale

0.712

High

205259

AXIN1
Axin-1

1

3

Small-scale

0.691

High

1209209

GSK3B
Glycogen synthase kinase-3 beta

1

17

Small-scale

0.691

High

996612

1433T
14-3-3 protein theta

4

20

Small-scale

0.687

High

1204351

TAOK1
Serine/threonine-protein kinase TAO1

1

12

Small-scale

0.647

High

725580

KAP3
cAMP-dependent protein kinase type II-beta regulatory subunit

1

5

Small-scale

0.646

High

1209182

DNM1L
Dynamin-1-like protein

3

8

Small-scale

0.643

High

148421

RGS2
Regulator of G-protein signaling 2

1

3

Small-scale

0.618

High

884989

CDK5
Cyclin-dependent kinase 5

1

10

Small-scale

0.618

High

946714

RIPK2
Receptor-interacting serine/threonine-protein kinase 2

1

20

Small-scale

0.618

High

953802

CDC42
Cell division control protein 42 homolog

1

9

Small-scale

0.618

High

988886

RAC1
Ras-related C3 botulinum toxin substrate 1

1

9

Small-scale

0.618

High

1190516

PAK6
Serine/threonine-protein kinase PAK 6

1

9

Small-scale

0.618

High

1209174

RIPK1
Receptor-interacting serine/threonine-protein kinase 1

1

20

Small-scale

0.618

High

1209176

CDC37
Hsp90 co-chaperone Cdc37

1

6

Small-scale

0.618

High

1209177

FADD
FAS-associated death domain protein

1

5

Small-scale

0.618

High

1209186

RAB7L
Ras-related protein Rab-7L1

1

15

Small-scale

0.618

High

1209201

ARHG7
Rho guanine nucleotide exchange factor 7

1

4

Small-scale

0.618

High

967102

1433G
14-3-3 protein gamma [Cleaved into: 14-3-3 protein gamma, N-terminally processed]

2

20

Small-scale

0.612

High

972224

1433E
14-3-3 protein epsilon

2

13

Small-scale

0.612

High

989966

1433Z
14-3-3 protein zeta/delta

2

20

Small-scale

0.612

High

999076

1433F
14-3-3 protein eta

2

20

Small-scale

0.612

High

1209191

1433B
14-3-3 protein beta/alpha

2

20

Small-scale

0.612

High

857221

NSF
Vesicle-fusing ATPase

2

2

Small-scale

0.584

High

424713

KAPCA
cAMP-dependent protein kinase catalytic subunit alpha

1

8

Small-scale

0.575

High

465814

ENPL
Endoplasmin

1

17

High-throughput

0.575

High

993094

ACTG
Actin, cytoplasmic 2

1

10

Small-scale

0.575

High

1021395

MPRIP
Myosin phosphatase Rho-interacting protein

1

13

Small-scale

0.575

High

1209179

ACTBL
Beta-actin-like protein 2

1

10

Small-scale

0.575

High

1209187

ARP3
Actin-related protein 3

1

10

Small-scale

0.575

High

1209196

MYPT1
Protein phosphatase 1 regulatory subunit 12A

1

5

Small-scale

0.575

High

1209197

RAI14
Ankycorbin

1

4

Small-scale

0.575

High

1209200

LIMA1
LIM domain and actin-binding protein 1

1

6

Small-scale

0.575

High

1036060

CTNB1
Catenin beta-1

1

8

Small-scale

0.536

High

1209175

DVL3
Segment polarity protein dishevelled homolog DVL-3

1

7

Small-scale

0.536

High

1209181

BAG5
BAG family molecular chaperone regulator 5

1

4

Small-scale

0.536

High

236699

WSB1
WD repeat and SOCS box-containing protein 1

1

9

Small-scale

0.515

High

1209207

CHIP
E3 ubiquitin-protein ligase CHIP

1

13

Small-scale

0.515

High

1189369

ML12B
Myosin regulatory light chain 12B

1

13

Small-scale

0.514

High

408249

MBP
Myelin basic protein

1

1

Small-scale

0.501

High

237234

AT2A2
Sarcoplasmic/endoplasmic reticulum calcium ATPase 2

1

3

High-throughput

0.500

High

98302

SC16A
Protein transport protein Sec16A

1

4

Small-scale

0.479

High

237096

SYUA
Alpha-synuclein

1

1

Small-scale

0.479

High

530814

TAU
Microtubule-associated protein tau

1

7

Small-scale

0.479

High

900706

DVL1
Segment polarity protein dishevelled homolog DVL-1

1

6

Small-scale

0.479

High

1196072

HERC2
E3 ubiquitin-protein ligase HERC2

1

11

Small-scale

0.479

High

1208438

NEUL4
Neuralized-like protein 4

1

3

Small-scale

0.479

High

1209178

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

1

6

High-throughput

0.479

High

1209180

Q8CG29
Myosin IF

1

12

Small-scale

0.479

High

1209184

MYH9
Myosin-9

1

4

Small-scale

0.479

High

1209190

FIS1
Mitochondrial fission 1 protein

1

1

Small-scale

0.479

High

1209194

TBB4A
Tubulin beta-4A chain

1

12

Small-scale

0.479

High

1209198

ARFG1
ADP-ribosylation factor GTPase-activating protein 1

1

3

Small-scale

0.479

High

1209199

VPS35
Vacuolar protein sorting-associated protein 35

1

1

Small-scale

0.479

High

595194

KCNA3
Potassium voltage-gated channel subfamily A member 3

1

0

High-throughput

0.458

High

1209203

ARPC3
Actin-related protein 2/3 complex subunit 3

1

0

Small-scale

0.458

High

147956

STXB1
Syntaxin-binding protein 1

1

5

Small-scale

0.445

High

475866

GNAI2
Guanine nucleotide-binding protein G(i) subunit alpha-2

1

4

Small-scale

0.445

High

479091

PDIA1
Protein disulfide-isomerase

1

10

High-throughput

0.445

High

571213

CALR
Calreticulin

1

6

High-throughput

0.445

High

627469

BIP
Endoplasmic reticulum chaperone BiP

1

13

High-throughput

0.445

High

636003

TPM3
Tropomyosin alpha-3 chain

1

7

Small-scale

0.445

High

858745

MYO1B
Unconventional myosin-Ib

1

11

Small-scale

0.445

High

866575

CAZA1
F-actin-capping protein subunit alpha-1

1

6

Small-scale

0.445

High

866597

CAZA2
F-actin-capping protein subunit alpha-2

1

6

Small-scale

0.445

High

867578

CAPZB
F-actin-capping protein subunit beta

1

3

Small-scale

0.445

High

945991

OPA1
Dynamin-like GTPase OPA1, mitochondrial

1

9

Small-scale

0.445

High

946690

TPM1
Tropomyosin alpha-1 chain

1

7

Small-scale

0.445

High

946705

TPM2
Tropomyosin beta chain

1

7

Small-scale

0.445

High

948495

ARPC4
Actin-related protein 2/3 complex subunit 4

1

2

Small-scale

0.445

High

989478

VAMP2
Vesicle-associated membrane protein 2

1

1

Small-scale

0.445

High

999958

MYO1F
Unconventional myosin-If

1

12

Small-scale

0.445

High

1209172

MYO1D
Unconventional myosin-Id

1

11

Small-scale

0.445

High

1209183

TMX1
Thioredoxin-related transmembrane protein 1

1

16

High-throughput

0.445

High

1209185

ERLN1
Erlin-1

1

7

High-throughput

0.445

High

1209188

ATP5L
ATP synthase F(0) complex subunit g, mitochondrial

1

1

Small-scale

0.445

High

1209189

ARPC5
Actin-related protein 2/3 complex subunit 5

1

1

Small-scale

0.445

High

1209192

ARPC2
Actin-related protein 2/3 complex subunit 2

1

1

Small-scale

0.445

High

1209193

MPC2
Mitochondrial pyruvate carrier 2

1

1

Small-scale

0.445

High

1209195

EFHD2
EF-hand domain-containing protein D2

1

16

Small-scale

0.445

High

1209202

TMOD3
Tropomodulin-3

1

3

Small-scale

0.445

High

1209204

PLEC
Plectin

1

6

Small-scale

0.445

High

1209205

DREB
Drebrin

1

4

Small-scale

0.445

High

1209206

MYO1C
Unconventional myosin-Ic

1

9

Small-scale

0.445

High

1209208

ARC1B
Actin-related protein 2/3 complex subunit 1B

1

10

Small-scale

0.445

High

204926

STX1A
Syntaxin-1A

1

0

Small-scale

0.426

High

1209173

MYL6
Myosin light polypeptide 6

1

10

Small-scale

0.407

High


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Last updated: 11Aug2025