HitPredict

Interactor 1: ACTBL (Q562R1)
Beta-actin-like protein 2 (Kappa-actin)
Gene: ACTBL2

Interactor 2: MYO6 (Q9UM54)
Unconventional myosin-VI (Unconventional myosin-6)
Gene: MYO6

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	1.00	0.811

Property	Details
Experiments	28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Actin~Myosin_head
Common GO terms	GO:0005524 - ATP binding GO:0005737 - cytoplasm GO:0005884 - actin filament GO:0016020 - membrane GO:0070062 - extracellular exosome
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 376 Hs			1 1294
+	Hs
		930052 ACTG_HUMAN (3-376): 0: 595: 91.44		MYO6_HUMAN (1-1294): 0: 1083: 100.00
+	Hs
		932453 ACTC_HUMAN (2-376): 0: 590: 88.27		MYO6_HUMAN (1-1294): 0: 1083: 100.00
+	Hs
		892049 ACTB_HUMAN (3-376): 0: 596: 91.71		MYO10_HUMAN (3-997): 0: 878: 30.44
+	Hs
		930011 ACTG_HUMAN (3-376): 0: 595: 91.44		MYO10_HUMAN (3-997): 0: 878: 30.44
+	Sc
		691273 ACT_YEAST (1-376): 0: 585: 82.98		MYO4_YEAST (2-1040): 0: 859: 26.02
+	Hs
		930015 ACTG_HUMAN (3-376): 0: 595: 91.44		MYO5C_HUMAN (772-1230): 2.22e-24: 113: 9.42
+	Hs
		932396 ACTC_HUMAN (2-376): 0: 590: 88.27		MYO5C_HUMAN (772-1230): 2.22e-24: 113: 9.42
+	Hs
		724859 ACTBL_HUMAN (1-376): 0: 616: 100.00		MYH9_HUMAN (842-1118): 6.25e-10: 66.2: 14.70
+	Mm
		892205 ACTB_MOUSE (3-376): 0: 596: 91.71		MYH9_MOUSE (765-1178): 3.23e-12: 73.5: 14.05
+	Rn
		892236 ACTB_RAT (3-376): 0: 596: 91.71		MYH10_RAT (831-1215): 6.35e-12: 72.8: 17.65
+	Rn
		892228 ACTB_RAT (3-376): 0: 596: 91.71		MYH9_RAT (765-1178): 3.18e-11: 70.5: 13.82
+	Hs
		724738 ACTB_HUMAN (3-376): 0: 596: 91.71		MYH9_HUMAN (842-1118): 6.25e-10: 66.2: 14.70
+	Hs
		724762 ACTG_HUMAN (3-376): 0: 595: 91.44		MYH9_HUMAN (842-1118): 6.25e-10: 66.2: 14.70
+	Hs
		724766 ACTC_HUMAN (2-376): 0: 590: 88.27		MYH9_HUMAN (842-1118): 6.25e-10: 66.2: 14.70
+	Hs
		724767 ACTS_HUMAN (2-376): 0: 590: 87.47		MYH9_HUMAN (842-1118): 6.25e-10: 66.2: 14.70
+	Hs
		725135 ACTH_HUMAN (1-376): 0: 590: 87.77		MYH10_HUMAN (762-1135): 7.28e-10: 65.8: 15.54
+	Hs
		725136 ACTC_HUMAN (2-376): 0: 590: 88.27		MYH10_HUMAN (762-1135): 7.28e-10: 65.8: 15.54
+	Sc
		585356 ACT_YEAST (1-376): 0: 585: 82.98		MYO2_YEAST (928-1223): 4.47e-10: 66.5: 9.09