Protein: NCOR2
Nuclear receptor corepressor 2 (N-CoR2) (CTG repeat protein 26) (SMAP270) (Silencing mediator of retinoic acid and thyroid hormone receptor) (SMRT) (T3 receptor-associating factor) (TRAC) (Thyroid-, retinoic-acid-receptor-associated corepressor)

Gene: NCOR2
Organism: Homo sapiens
Interactions: 241
UniProt ID: Q9Y618

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000785 - chromatin
GO:0003677 - DNA binding
GO:0003682 - chromatin binding
GO:0003714 - transcription corepressor activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

188400

HDAC3
Histone deacetylase 3

22

20

Small-scale

0.992

High

1098614

GPS2
G protein pathway suppressor 2

6

2

Small-scale

0.953

High

941109

HDAC4
Histone deacetylase 4

5

20

Small-scale

0.924

High

1111398

SNW1
SNW domain-containing protein 1

4

2

Small-scale

0.883

High

1110224

HDAC1
Histone deacetylase 1

3

20

Small-scale

0.855

High

1356787

HDAC7
Histone deacetylase 7

3

20

Small-scale

0.847

High

1368228

HDAC2
Histone deacetylase 2

3

20

Small-scale

0.847

High

1462755

HDAC5
Histone deacetylase 5

2

20

Small-scale

0.783

High

1381099

HDA10
Polyamine deacetylase HDAC10

2

20

Small-scale

0.776

High

832848

BCL6
B-cell lymphoma 6 protein

12

4

Small-scale

0.759

High

278457

NCOR1
Nuclear receptor corepressor 1

2

13

Small-scale

0.757

High

520653

RARA
Retinoic acid receptor alpha

11

20

Small-scale

0.756

High

520490

ANDR
Androgen receptor

10

20

Small-scale

0.756

High

789609

PPARG
Peroxisome proliferator-activated receptor gamma

11

20

Small-scale

0.750

High

533369

THB
Thyroid hormone receptor beta

8

20

Small-scale

0.747

High

1051445

ZBT16
Zinc finger and BTB domain-containing protein 16

7

3

Small-scale

0.746

High

261459

TBL1X
F-box-like/WD repeat-containing protein TBL1X

5

20

Small-scale

0.726

High

397334

ESR1
Estrogen receptor

5

20

Small-scale

0.710

High

1054825

SUH
Recombining binding protein suppressor of hairless

5

4

Small-scale

0.707

High

625857

RXRA
Retinoic acid receptor RXR-alpha

5

20

Small-scale

0.702

High

1045959

TF65
Transcription factor p65

4

10

Small-scale

0.701

High

1403528

MINT
Msx2-interacting protein

3

8

Small-scale

0.682

High

777337

AHR
Aryl hydrocarbon receptor

3

9

Small-scale

0.680

High

1055296

MTG8
Protein CBFA2T1

3

9

Small-scale

0.672

High

980625

H4
Histone H4

3

6

Small-scale

0.667

High

576269

PO2F1
POU domain, class 2, transcription factor 1

3

14

Small-scale

0.664

High

282957

NR1I2
Nuclear receptor subfamily 1 group I member 2

3

20

Small-scale

0.658

High

442968

PRGR
Progesterone receptor

3

20

Small-scale

0.653

High

533313

THA
Thyroid hormone receptor alpha

3

20

Small-scale

0.651

High

714558

PML
Protein PML

3

14

Small-scale

0.646

High

334600

ZBT7A
Zinc finger and BTB domain-containing protein 7A

3

11

Small-scale

0.642

High

404578

GCR
Glucocorticoid receptor

3

20

Small-scale

0.642

High

414927

P53
Cellular tumor antigen p53

2

5

Small-scale

0.641

High

872949

SOX2
Transcription factor SOX-2

3

20

Small-scale

0.640

High

1367702

ESR2
Estrogen receptor beta

3

20

Small-scale

0.640

High

373639

MYC
Myc proto-oncogene protein

3

9

High-throughput

0.633

High

1060643

PPARA
Peroxisome proliferator-activated receptor alpha

2

20

Small-scale

0.633

High

505631

ATX1L
Ataxin-1-like

2

8

Small-scale

0.631

High

652610

NR4A1
Nuclear receptor subfamily 4immunitygroup A member 1

2

20

Small-scale

0.631

High

1029797

FOXK2
Forkhead box protein K2

2

15

Small-scale

0.628

High

1410253

TBL1Y
F-box-like/WD repeat-containing protein TBL1Y

2

19

High-throughput

0.628

High

1414250

ZSA5A
Zinc finger and SCAN domain-containing protein 5A

2

6

High-throughput

0.628

High

1041811

PPARD
Peroxisome proliferator-activated receptor delta

2

20

Small-scale

0.625

High

1118800

KLF5
Krueppel-like factor 5

2

18

Small-scale

0.620

High

142643

IMA3
Importin subunit alpha-3

2

3

Small-scale

0.619

High

1109431

PIN1
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1

2

2

Small-scale

0.619

High

1067888

EP300
Histone acetyltransferase p300

1

17

Small-scale

0.618

High

1368542

CBP
CREB-binding protein

1

12

Small-scale

0.618

High

683545

IKBA
NF-kappa-B inhibitor alpha

2

13

Small-scale

0.612

High

370828

FOS
Protein c-Fos

2

9

Small-scale

0.606

High

177972

IKKA
Inhibitor of nuclear factor kappa-B kinase subunit alpha

2

3

Small-scale

0.602

High

834104

HNF4A
Hepatocyte nuclear factor 4-alpha

2

20

Small-scale

0.595

High

1403059

SIN3A
Paired amphipathic helix protein Sin3a

2

6

Small-scale

0.595

High

543555

VDR
Vitamin D3 receptor

2

20

Small-scale

0.594

High

933967

NR1H2
Oxysterols receptor LXR-beta

2

20

Small-scale

0.594

High

1461069

TNIK
TRAF2 and NCK-interacting protein kinase

2

8

High-throughput

0.590

High

927637

ATX1
Ataxin-1

2

8

Small-scale

0.586

High

143358

NFIB
Nuclear factor 1 B-type

2

20

High-throughput

0.584

High

260661

BRD4
Bromodomain-containing protein 4

2

12

High-throughput

0.584

High

474409

NFIC
Nuclear factor 1 C-type

2

20

High-throughput

0.584

High

1088132

NFIA
Nuclear factor 1 A-type

2

20

High-throughput

0.584

High

1103481

CTBP1
C-terminal-binding protein 1

2

8

Small-scale

0.584

High

1133763

NFIX
Nuclear factor 1 X-type

2

20

High-throughput

0.584

High

1429931

UBP44
Ubiquitin carboxyl-terminal hydrolase 44

2

4

Small-scale

0.584

High

1029183

E2F1
Transcription factor E2F1

1

5

High-throughput

0.578

High

1110329

KCC2B
Calcium/calmodulin-dependent protein kinase type II subunit beta

1

2

Small-scale

0.578

High

1398426

CEP63
Centrosomal protein of 63 kDa

2

10

High-throughput

0.576

High

176427

ZBTB5
Zinc finger and BTB domain-containing protein 5

1

16

Small-scale

0.573

High

465062

SP1
Transcription factor Sp1

1

11

Small-scale

0.573

High

555542

SKIL
Ski-like protein

1

3

Small-scale

0.573

High

693384

ARNT
Aryl hydrocarbon receptor nuclear translocator

1

5

Small-scale

0.569

High

607277

CEBPB
CCAAT/enhancer-binding protein beta

1

9

Small-scale

0.561

High

668095

CDK2
Cyclin-dependent kinase 2

1

2

Small-scale

0.561

High

1110896

IRF5
Interferon regulatory factor 5

1

3

Small-scale

0.561

High

1156724

NF2L2
Nuclear factor erythroid 2-related factor 2

1

11

Small-scale

0.561

High

1432501

FOXP1
Forkhead box protein P1

1

17

Small-scale

0.561

High

1491796

NCOA3
Nuclear receptor coactivator 3

1

8

Small-scale

0.561

High

1144813

NADC
Nicotinate-nucleotide pyrophosphorylase [carboxylating]

2

2

High-throughput

0.549

High

458521

ADRB2
Beta-2 adrenergic receptor

1

1

High-throughput

0.541

High

261572

B4GT2
Beta-1,4-galactosyltransferase 2

1

2

High-throughput

0.536

High

282332

SAP30
Histone deacetylase complex subunit SAP30

1

2

Small-scale

0.536

High

339028

CBX6
Chromobox protein homolog 6

1

5

High-throughput

0.536

High

885017

DGKG
Diacylglycerol kinase gamma

1

2

High-throughput

0.536

High

1123186

FHL2
Four and a half LIM domains protein 2

1

8

High-throughput

0.536

High

1407024

NPAS1
Neuronal PAS domain-containing protein 1

1

6

High-throughput

0.536

High

1419366

BACH2
Transcription regulator protein BACH2

1

19

High-throughput

0.536

High

1435516

EGLN3
Prolyl hydroxylase EGLN3

1

1

High-throughput

0.536

High

1063733

GOGA2
Golgin subfamily A member 2

2

8

High-throughput

0.533

High

430568

JUN
Transcription factor Jun

1

10

Small-scale

0.527

High

549361

SRF
Serum response factor

1

2

Small-scale

0.527

High

728504

AKT1
RAC-alpha serine/threonine-protein kinase

1

0

Small-scale

0.513

High

127802

IKBE
NF-kappa-B inhibitor epsilon

1

15

Small-scale

0.501

High

137551

NR5A2
Nuclear receptor subfamily 5 group A member 2

1

20

Small-scale

0.501

High

508916

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

8

High-throughput

0.501

High

631848

NR1D1
Nuclear receptor subfamily 1 group D member 1

1

20

Small-scale

0.501

High

991469

SUMO1
Small ubiquitin-related modifier 1

1

6

Small-scale

0.501

High

993833

UBC9
SUMO-conjugating enzyme UBC9

1

3

Small-scale

0.501

High

1095519

NR1H3
Oxysterols receptor LXR-alpha

1

20

Small-scale

0.501

High

1119088

C1D
Nuclear nucleic acid-binding protein C1D

1

1

Small-scale

0.501

High

1151510

IKBB
NF-kappa-B inhibitor beta

1

15

Small-scale

0.501

High

1401348

NR1H4
Bile acid receptor

1

20

Small-scale

0.501

High

1179890

INSY1
Inhibitory synaptic factor 1

1

2

High-throughput

0.489

High

1245346

WDR59
GATOR2 complex protein WDR59

1

19

High-throughput

0.489

High

1410834

SGIP1
SH3-containing GRB2-like protein 3-interacting protein 1

1

4

High-throughput

0.489

High

533238

RARB
Retinoic acid receptor beta

1

20

High-throughput

0.481

High

565542

RARG
Retinoic acid receptor gamma

1

20

High-throughput

0.481

High

873173

RXRG
Retinoic acid receptor RXR-gamma

1

20

High-throughput

0.481

High

1130616

NCOA6
Nuclear receptor coactivator 6

1

17

Small-scale

0.481

High

1402361

RANB9
Ran-binding protein 9

1

5

High-throughput

0.481

High

1413116

INP5K
Inositol polyphosphate 5-phosphatase K

1

3

Small-scale

0.481

High

1453520

CNOT2
CCR4-NOT transcription complex subunit 2

1

5

Small-scale

0.481

High

124668

EYA2
Protein phosphatase EYA2

1

11

High-throughput

0.479

High

130669

SPT5H
Transcription elongation factor SPT5

1

9

High-throughput

0.479

High

170455

AURKA
Aurora kinase A

1

5

High-throughput

0.479

High

181585

TBXT
T-box transcription factor T

1

10

High-throughput

0.479

High

210153

CRX
Cone-rod homeobox protein

1

20

High-throughput

0.479

High

225151

TLX3
T-cell leukemia homeobox protein 3

1

20

High-throughput

0.479

High

226628

TLX2
T-cell leukemia homeobox protein 2

1

16

High-throughput

0.479

High

240023

SOX15
Transcription factor SOX-15

1

20

High-throughput

0.479

High

289198

PRDM1
PR domain zinc finger protein 1

1

4

High-throughput

0.479

High

323628

TRI37
E3 ubiquitin-protein ligase TRIM37

1

11

High-throughput

0.479

High

337415

PARN
Poly(A)-specific ribonuclease PARN

1

1

High-throughput

0.479

High

339910

KLF8
Krueppel-like factor 8

1

18

High-throughput

0.479

High

341713

EYA4
Protein phosphatase EYA4

1

13

High-throughput

0.479

High

342388

BRD1
Bromodomain-containing protein 1

1

10

High-throughput

0.479

High

448082

ITAV
Integrin alpha-V

1

1

Small-scale

0.479

High

535728

BIP
Endoplasmic reticulum chaperone BiP

1

6

High-throughput

0.479

High

538499

EGR2
E3 SUMO-protein ligase EGR2

1

3

High-throughput

0.479

High

540976

ERG
Transcriptional regulator ERG

1

11

High-throughput

0.479

High

566086

EF2
Elongation factor 2

1

1

High-throughput

0.479

High

581748

MYOD1
Myoblast determination protein 1

1

8

High-throughput

0.479

High

590150

RFA2
Replication protein A 32 kDa subunit

1

5

High-throughput

0.479

High

590512

GATA1
Erythroid transcription factor

1

13

High-throughput

0.479

High

601924

HMGA1
High mobility group protein HMG-I/HMG-Y

1

4

Small-scale

0.479

High

662304

PAX7
Paired box protein Pax-7

1

20

High-throughput

0.479

High

662526

GATA2
Endothelial transcription factor GATA-2

1

13

High-throughput

0.479

High

662679

GATA3
Trans-acting T-cell-specific transcription factor GATA-3

1

13

High-throughput

0.479

High

685400

PAX6
Paired box protein Pax-6

1

20

High-throughput

0.479

High

696991

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

5

High-throughput

0.479

High

703222

TEAD1
Transcriptional enhancer factor TEF-1

1

3

High-throughput

0.479

High

725348

TLX1
T-cell leukemia homeobox protein 1

1

20

High-throughput

0.479

High

769637

RFA3
Replication protein A 14 kDa subunit

1

5

High-throughput

0.479

High

775942

HNF1B
Hepatocyte nuclear factor 1-beta

1

20

High-throughput

0.479

High

776157

SOX5
Transcription factor SOX-5

1

20

High-throughput

0.479

High

776276

SOX6
Transcription factor SOX-6

1

20

High-throughput

0.479

High

837113

ELK3
ETS domain-containing protein Elk-3

1

13

High-throughput

0.479

High

846944

ETV4
ETS translocation variant 4

1

12

High-throughput

0.479

High

848115

NR4A2
Nuclear receptor subfamily 4 group A member 2

1

20

Small-scale

0.479

High

851716

GATA4
Transcription factor GATA-4

1

14

High-throughput

0.479

High

877585

LHX1
LIM/homeobox protein Lhx1

1

12

High-throughput

0.479

High

887389

CEBPA
CCAAT/enhancer-binding protein alpha

1

11

High-throughput

0.479

High

895828

LHX2
LIM/homeobox protein Lhx2

1

12

High-throughput

0.479

High

938523

PAX9
Paired box protein Pax-9

1

19

High-throughput

0.479

High

942132

SOX10
Transcription factor SOX-10

1

20

High-throughput

0.479

High

942482

GSC
Homeobox protein goosecoid

1

15

High-throughput

0.479

High

944773

KLF3
Krueppel-like factor 3

1

20

High-throughput

0.479

High

951928

PTEN
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

1

2

Small-scale

0.479

High

1033831

PO5F1
POU domain, class 5, transcription factor 1

1

12

High-throughput

0.479

High

1040095

PAX2
Paired box protein Pax-2

1

19

High-throughput

0.479

High

1048146

TLE3
Transducin-like enhancer protein 3

1

17

High-throughput

0.479

High

1052928

HME1
Homeobox protein engrailed-1

1

10

High-throughput

0.479

High

1056665

PAX8
Paired box protein Pax-8

1

19

High-throughput

0.479

High

1091268

FOXI1
Forkhead box protein I1

1

14

High-throughput

0.479

High

1091386

FOXL1
Forkhead box protein L1

1

14

High-throughput

0.479

High

1094834

CAF1B
Chromatin assembly factor 1 subunit B

1

14

Small-scale

0.479

High

1104709

IKZF1
DNA-binding protein Ikaros

1

1

Small-scale

0.479

High

1107386

BIRC3
Baculoviral IAP repeat-containing protein 3

1

4

Small-scale

0.479

High

1116179

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

10

High-throughput

0.479

High

1143714

Q15156
Protein PML

1

20

Small-scale

0.479

High

1145853

IRF4
Interferon regulatory factor 4

1

3

High-throughput

0.479

High

1150857

SF01
Splicing factor 1

1

3

Small-scale

0.479

High

1156078

ZBTB6
Zinc finger and BTB domain-containing protein 6

1

7

Small-scale

0.479

High

1156919

E2F4
Transcription factor E2F4

1

5

Small-scale

0.479

High

1159062

RBBP7
Histone-binding protein RBBP7

1

7

High-throughput

0.479

High

1160907

TBR1
T-box brain protein 1

1

10

High-throughput

0.479

High

1213488

DCA12
DDB1- and CUL4-associated factor 12

1

3

High-throughput

0.479

High

1229804

VIR
Protein virilizer homolog

1

2

High-throughput

0.479

High

1247331

BRWD3
Bromodomain and WD repeat-containing protein 3

1

20

High-throughput

0.479

High

1250701

BCOR
BCL-6 corepressor

1

16

Small-scale

0.479

High

1252311

SYNE3
Nesprin-3

1

7

High-throughput

0.479

High

1277051

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

4

High-throughput

0.479

High

1279318

I2BP2
Interferon regulatory factor 2-binding protein 2

1

8

Small-scale

0.479

High

1289346

DTX2
Probable E3 ubiquitin-protein ligase DTX2

1

5

High-throughput

0.479

High

1313577

SMC5
Structural maintenance of chromosomes protein 5

1

4

High-throughput

0.479

High

1338460

FBX22
F-box only protein 22

1

5

High-throughput

0.479

High

1339076

NUP43
Nucleoporin Nup43

1

15

High-throughput

0.479

High

1339253

NUP35
Nucleoporin NUP35

1

2

High-throughput

0.479

High

1340849

COP1
E3 ubiquitin-protein ligase COP1

1

13

High-throughput

0.479

High

1351212

SP7
Transcription factor Sp7

1

15

High-throughput

0.479

High

1357626

DCAF4
DDB1- and CUL4-associated factor 4

1

1

High-throughput

0.479

High

1359734

PHIP
PH-interacting protein

1

20

High-throughput

0.479

High

1364028

SMG7
Nonsense-mediated mRNA decay factor SMG7

1

2

High-throughput

0.479

High

1379979

LHX4
LIM/homeobox protein Lhx4

1

12

High-throughput

0.479

High

1387667

SNR40
U5 small nuclear ribonucleoprotein 40 kDa protein

1

20

High-throughput

0.479

High

1405467

FEV
Protein FEV

1

10

High-throughput

0.479

High

1413243

SOX7
Transcription factor SOX-7

1

20

High-throughput

0.479

High

1420528

FOXQ1
Forkhead box protein Q1

1

16

High-throughput

0.479

High

1434988

SOX17
Transcription factor SOX-17

1

20

High-throughput

0.479

High

1437254

NANOG
Homeobox protein NANOG

1

20

High-throughput

0.479

High

1445872

GCM1
Chorion-specific transcription factor GCMa

1

3

High-throughput

0.479

High

1450956

NLE1
Notchless protein homolog 1

1

15

High-throughput

0.479

High

1452499

TE2IP
Telomeric repeat-binding factor 2-interacting protein 1

1

3

High-throughput

0.479

High

1458651

LHX3
LIM/homeobox protein Lhx3

1

12

High-throughput

0.479

High

1460406

KLF15
Krueppel-like factor 15

1

16

High-throughput

0.479

High

1461365

BAG5
BAG family molecular chaperone regulator 5

1

4

High-throughput

0.479

High

1490620

ASF1A
Histone chaperone ASF1A

1

7

High-throughput

0.479

High

1490656

FBW1A
F-box/WD repeat-containing protein 1A

1

18

Small-scale

0.479

High

1491361

TRRAP
Transformation/transcription domain-associated protein

1

4

High-throughput

0.479

High

1293540

CIR1
Corepressor interacting with RBPJ 1

1

0

Small-scale

0.460

High

1339781

TNIP2
TNFAIP3-interacting protein 2

1

0

High-throughput

0.460

High

933920

GEM
GTP-binding protein GEM

1

0

Small-scale

0.458

High

1005294

RNF4
E3 ubiquitin-protein ligase RNF4

1

0

High-throughput

0.458

High

1244852

FBX38
F-box only protein 38

1

0

High-throughput

0.458

High

407742

S100B
Protein S100-B

1

3

High-throughput

0.445

High

538184

HSP7C
Heat shock cognate 71 kDa protein

1

3

High-throughput

0.445

High

555443

SKI
Ski oncogene

1

3

Small-scale

0.445

High

848845

MAGAA
Melanoma-associated antigen 10

1

4

High-throughput

0.445

High

896482

ERF
ETS domain-containing transcription factor ERF

1

13

High-throughput

0.445

High

939242

SUMO3
Small ubiquitin-related modifier 3

1

6

Small-scale

0.445

High

1029982

RUNX1
Runt-related transcription factor 1

1

2

Small-scale

0.445

High

1351656

TCP1L
T-complex protein 10A homolog 1

1

1

High-throughput

0.445

High

1408168

BAG1
BAG family molecular chaperone regulator 1

1

1

Small-scale

0.445

High

1386761

AP2M1
AP-2 complex subunit mu

1

2

High-throughput

0.439

High

137007

AGRIN
Agrin [Cleaved into: Agrin N-terminal 110 kDa subunit; Agrin C-terminal 110 kDa subunit; Agrin C-terminal 90 kDa fragment

1

6

High-throughput

0.437

High

175276

SC16A
Protein transport protein Sec16A

1

13

High-throughput

0.437

High

229591

NRDC
Nardilysin

1

3

Small-scale

0.437

High

834243

CSK
Tyrosine-protein kinase CSK

1

3

High-throughput

0.437

High

1133201

LASP1
LIM and SH3 domain protein 1

1

17

Small-scale

0.437

High

1142048

EEA1
Early endosome antigen 1

1

7

High-throughput

0.437

High

1241995

FBX42
F-box only protein 42

1

7

High-throughput

0.437

High

1315333

ZDH23
Palmitoyltransferase ZDHHC23

1

1

Small-scale

0.437

High

1384207

RGMA
Repulsive guidance molecule A

1

1

High-throughput

0.437

High

1445974

ALG13
UDP-N-acetylglucosamine transferase subunit ALG13

1

6

High-throughput

0.437

High

1454561

RHG20
Rho GTPase-activating protein 20

1

6

High-throughput

0.437

High

347441

BAG2
BAG family molecular chaperone regulator 2

1

2

High-throughput

0.407

High

880413

RL34
Large ribosomal subunit protein eL34

1

0

High-throughput

0.279

Low

1388003

RM38
Large ribosomal subunit protein mL38

1

0

High-throughput

0.279

Low

518793

IL8
Interleukin-8

1

0

Small-scale

0.249

Low

1449775

ZDH18
Palmitoyltransferase ZDHHC18

1

0

Small-scale

0.249

Low

1389323

T3HPD
Trans-3-hydroxy-L-proline dehydratase

1

0

High-throughput

0.232

Low

1490478

CLC11
C-type lectin domain family 11 member A

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025