HitPredict

Interactor 1: PYDC2 (Q56P42)
Pyrin domain-containing protein 2 (Pyrin-only protein 2) (cellular POP2) (cPOP2)
Gene: PYDC2

Interactor 2: NALP4 (Q96MN2)
NACHT, LRR and PYD domains-containing protein 4 (Cancer/testis antigen 58) (CT58) (PAAD and NACHT-containing protein 2) (PAN2) (PYRIN and NACHT-containing protein 2) (PYRIN-containing APAF1-like protein 4) (PYPAF4) (Ribonuclease inhibitor 2)
Gene: NLRP4

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.34	1.00	0.590

Property	Details
Experiments	17178784
Identification Methods	two hybrid
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PYRIN~PYRIN
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0006954 - inflammatory response
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 97 Hs			1 994
+	Hs
		1202832 NAL14_HUMAN (7-91): 1.59e-29: 112: 30.59		NAL14_HUMAN (7-990): 0: 736: 37.46
+	Hs
		1122746 PYDC2_HUMAN (1-97): 1.23e-34: 115: 100.00		NALP2_HUMAN (1-982): 0: 618: 30.81
+	Hs
		1202833 NAL10_HUMAN (1-93): 1.05e-26: 103: 19.36		NAL10_HUMAN (1-565): 3.41e-147: 454: 27.74
+	Mm
		1246896 NLRP3_MOUSE (6-91): 9.3e-30: 112: 23.26		NLRP3_MOUSE (729-990): 7.9e-42: 168: 41.07
+	Hs
		1299023 NLRP3_HUMAN (3-91): 1.7e-29: 111: 22.47		NLRP3_HUMAN (730-990): 5.23e-42: 169: 39.70
+	Hs
		886444 NLRP3_HUMAN (3-91): 1.7e-29: 111: 22.47		NALP5_HUMAN (597-904): 2.56e-38: 157: 28.83
+	Hs
		183332 MEFV_HUMAN (1-90): 1.47e-24: 97.8: 22.22		NLRP3_HUMAN (730-990): 5.23e-42: 169: 39.70
+	Hs
		886448 NALP2_HUMAN (1-91): 7.16e-28: 107: 67.03		NALP5_HUMAN (597-904): 2.56e-38: 157: 28.83
+	Hs
		1299030 NLRP3_HUMAN (3-91): 1.7e-29: 111: 22.47		NOD2_HUMAN (698-971): 9.31e-26: 117: 24.82
+	Hs
		1263222 NALP2_HUMAN (1-91): 7.16e-28: 107: 67.03		NALP7_HUMAN (680-990): 8.27e-26: 117: 24.84
+	Hs
		886442 NALP5_HUMAN (6-91): 9.09e-26: 101: 27.91		NALP7_HUMAN (680-990): 8.27e-26: 117: 24.84
+	Hs
		1263202 NALP7_HUMAN (3-91): 9.39e-25: 98.2: 41.57		NALP7_HUMAN (680-990): 8.27e-26: 117: 24.84
+	Hs
		886408 PYDC2_HUMAN (1-97): 1.23e-34: 115: 100.00		NAL12_HUMAN (848-992): 6.87e-19: 94.7: 35.17
+	Hs
		1297962 NALP4_HUMAN (1-91): 1.42e-36: 132: 31.87		NLRC4_HUMAN (763-993): 1.78e-10: 67.4: 15.02
+	Hs
		1122745 PYDC2_HUMAN (1-97): 1.23e-34: 115: 100.00		NLRP1_HUMAN (900-992): 4.18e-10: 66.2: 29.03
+	Hs
		1299032 NLRP3_HUMAN (3-91): 1.7e-29: 111: 22.47		NLRC4_HUMAN (763-993): 1.78e-10: 67.4: 15.02