HitPredict

Interactor 1: HS904 (Q58FG1)
Putative heat shock protein HSP 90-alpha A4 (Heat shock 90 kDa protein 1 alpha-like 2) (Heat shock protein 90-alpha D) (Heat shock protein 90Ad)
Gene: HSP90AA4P

Interactor 2: LATS2 (Q9NRM7)
Serine/threonine-protein kinase LATS2 (EC 2.7.11.1) (Kinase phosphorylated during mitosis protein) (Large tumor suppressor homolog 2) (Serine/threonine-protein kinase kpm) (Warts-like kinase)
Gene: LATS2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	1.00	0.575

Property	Details
Experiments	32707033
Identification Methods	pull down
Interaction Type	association

Property	Details
Interacting Pfam domains	HSP90~Pkinase
Common GO terms	GO:0005524 - ATP binding GO:0005634 - nucleus GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 418 Hs			1 1088
+	Hs
		325763 HS904_HUMAN (1-418): 0: 547: 100.00		LATS1_HUMAN (1-1083): 0: 734: 49.61
+	Hs
		432293 HS90A_HUMAN (96-271): 2.07e-45: 169: 51.41		LATS2_HUMAN (1-1088): 0: 983: 100.00
+	Hs
		1123562 HS904_HUMAN (1-418): 0: 547: 100.00		AKT3_HUMAN (532-1043): 3.66e-141: 435: 22.01
+	Hs
		610733 HS904_HUMAN (1-418): 0: 547: 100.00		KAPCB_HUMAN (638-1022): 1.92e-133: 410: 31.36
+	Hs
		969092 H90B2_HUMAN (2-304): 8.06e-80: 252: 34.81		KPCE_HUMAN (554-1010): 1.06e-129: 413: 29.92
+	Hs
		431870 HS90A_HUMAN (96-271): 2.07e-45: 169: 51.41		STK38_HUMAN (583-1065): 5.24e-146: 447: 40.58
+	Hs
		1123464 H90B3_HUMAN (2-153): 1.55e-48: 175: 50.66		AKT3_HUMAN (532-1043): 3.66e-141: 435: 22.01
+	Hs
		681885 H90B3_HUMAN (2-153): 1.55e-48: 175: 50.66		AKT1_HUMAN (532-1043): 2.2e-141: 435: 22.16
+	Hs
		431573 HS90A_HUMAN (96-271): 2.07e-45: 169: 51.41		AKT2_HUMAN (532-1043): 1.88e-142: 438: 23.64
+	Hs
		431572 HS90A_HUMAN (96-271): 2.07e-45: 169: 51.41		AKT1_HUMAN (532-1043): 2.2e-141: 435: 22.16
+	Hs
		431752 HS90A_HUMAN (96-271): 2.07e-45: 169: 51.41		KPCE_HUMAN (554-1010): 1.06e-129: 413: 29.92
+	Hs
		431511 HS90A_HUMAN (96-271): 2.07e-45: 169: 51.41		KAPCA_HUMAN (635-1024): 1.31e-133: 410: 31.73
+	Hs
		431538 HS90A_HUMAN (96-271): 2.07e-45: 169: 51.41		KAPCB_HUMAN (638-1022): 1.92e-133: 410: 31.36
+	Hs
		70435 HS90A_HUMAN (96-271): 2.07e-45: 169: 51.41		B2RB89_HUMAN (638-1022): 1.92e-133: 410: 31.36
+	Hs
		116956 HS90A_HUMAN (96-271): 2.07e-45: 169: 51.41		SGK1_HUMAN (608-1042): 1.07e-131: 408: 28.51
+	Hs
		850666 H90B2_HUMAN (2-304): 8.06e-80: 252: 34.81		KS6A3_HUMAN (519-990): 8.69e-81: 281: 19.63
+	Hs
		1073431 H90B2_HUMAN (2-304): 8.06e-80: 252: 34.81		KS6A1_HUMAN (519-977): 1.47e-79: 277: 20.34
+	Hs
		431672 HS90A_HUMAN (96-271): 2.07e-45: 169: 51.41		KS6A3_HUMAN (519-990): 8.69e-81: 281: 19.63
+	Hs
		431876 HS90A_HUMAN (96-271): 2.07e-45: 169: 51.41		KS6A1_HUMAN (519-977): 1.47e-79: 277: 20.34
+	Hs
		431783 HS90A_HUMAN (96-271): 2.07e-45: 169: 51.41		DMPK_HUMAN (627-1007): 4.98e-66: 236: 35.90