HitPredict

Interactor 1: HS904 (Q58FG1)
Putative heat shock protein HSP 90-alpha A4 (Heat shock 90 kDa protein 1 alpha-like 2) (Heat shock protein 90-alpha D) (Heat shock protein 90Ad)
Gene: HSP90AA4P

Interactor 2: AKT3 (Q9Y243)
RAC-gamma serine/threonine-protein kinase (EC 2.7.11.1) (Protein kinase Akt-3) (Protein kinase B gamma) (PKB gamma) (RAC-PK-gamma) (STK-2)
Gene: AKT3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.50	1.00	0.712

Property	Details
Experiments	28514442, 33961781
Identification Methods	anti tag coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	HSP90~Pkinase
Common GO terms	GO:0005524 - ATP binding GO:0005634 - nucleus
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 418 Hs			1 479
+	Hs
		1123539 HS904_HUMAN (1-418): 0: 547: 100.00		SGK3_HUMAN (61-479): 4.68e-149: 436: 42.35
+	Hs
		1123553 HS904_HUMAN (1-418): 0: 547: 100.00		SGK2_HUMAN (117-474): 5.54e-146: 423: 48.07
+	Hs
		1123464 H90B3_HUMAN (2-153): 1.55e-48: 175: 50.66		AKT3_HUMAN (1-479): 0: 589: 100.00
+	Hs
		681885 H90B3_HUMAN (2-153): 1.55e-48: 175: 50.66		AKT1_HUMAN (1-477): 0: 558: 82.29
+	Hs
		431573 HS90A_HUMAN (96-271): 2.07e-45: 169: 51.41		AKT2_HUMAN (1-479): 0: 561: 75.78
+	Hs
		431572 HS90A_HUMAN (96-271): 2.07e-45: 169: 51.41		AKT1_HUMAN (1-477): 0: 558: 82.29
+	Hs
		969092 H90B2_HUMAN (2-304): 8.06e-80: 252: 34.81		KPCE_HUMAN (52-473): 1.57e-148: 443: 41.41
+	Hs
		431510 HS90A_HUMAN (96-271): 2.07e-45: 169: 51.41		KPCA_HUMAN (13-476): 6.53e-152: 449: 36.75
+	Hs
		431548 HS90A_HUMAN (96-271): 2.07e-45: 169: 51.41		KPCL_HUMAN (110-476): 8.45e-151: 447: 41.73
+	Hs
		431752 HS90A_HUMAN (96-271): 2.07e-45: 169: 51.41		KPCE_HUMAN (52-473): 1.57e-148: 443: 41.41
+	Hs
		408527 HS90A_HUMAN (96-271): 2.07e-45: 169: 51.41		KPCB_HUMAN (13-476): 3.8e-149: 442: 36.94
+	Hs
		431542 HS90A_HUMAN (96-271): 2.07e-45: 169: 51.41		KS6B1_HUMAN (89-477): 4.14e-149: 437: 38.68
+	Hs
		431762 HS90A_HUMAN (96-271): 2.07e-45: 169: 51.41		KPCT_HUMAN (85-479): 8.26e-147: 437: 39.39
+	Hs
		432138 HS90A_HUMAN (96-271): 2.07e-45: 169: 51.41		SGK3_HUMAN (61-479): 4.68e-149: 436: 42.35
+	Hs
		116956 HS90A_HUMAN (96-271): 2.07e-45: 169: 51.41		SGK1_HUMAN (100-477): 4.38e-147: 428: 45.12
+	Hs
		1073431 H90B2_HUMAN (2-304): 8.06e-80: 252: 34.81		KS6A1_HUMAN (54-459): 5.85e-103: 325: 21.91
+	Hs
		850666 H90B2_HUMAN (2-304): 8.06e-80: 252: 34.81		KS6A3_HUMAN (146-418): 7.07e-101: 320: 28.52
+	Hs
		431876 HS90A_HUMAN (96-271): 2.07e-45: 169: 51.41		KS6A1_HUMAN (54-459): 5.85e-103: 325: 21.91
+	Hs
		431672 HS90A_HUMAN (96-271): 2.07e-45: 169: 51.41		KS6A3_HUMAN (146-418): 7.07e-101: 320: 28.52
+	Hs
		431621 HS90A_HUMAN (96-271): 2.07e-45: 169: 51.41		KPCI_HUMAN (118-473): 3.27e-101: 317: 43.94