Protein: NR4A1
Nuclear receptor subfamily 4immunitygroup A member 1 (Early response protein NAK1) (Nuclear hormone receptor NUR/77) (Nur77) (Orphan nuclear receptor HMR) (Orphan nuclear receptor TR3) (ST-59) (Testicular receptor 3)

Gene: NR4A1
Organism: Homo sapiens
Interactions: 228
UniProt ID: P22736

Gene Ontology (top 5):
GO:0000785 - chromatin
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001228 - DNA-binding transcription activator activity, RNA polymerase II-specific
GO:0001530 - lipopolysaccharide binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

587117

RXRA
Retinoic acid receptor RXR-alpha

3

20

Small-scale

0.856

High

611386

PPARG
Peroxisome proliferator-activated receptor gamma

2

20

Small-scale

0.792

High

611447

NCOA1
Nuclear receptor coactivator 1

2

20

Small-scale

0.768

High

611382

CTNB1
Catenin beta-1

2

20

Small-scale

0.754

High

489370

BCL2
Apoptosis regulator Bcl-2

3

8

Small-scale

0.692

High

377096

GCR
Glucocorticoid receptor

1

20

High-throughput

0.656

High

611492

PGBD1
PiggyBac transposable element-derived protein 1

2

7

High-throughput

0.654

High

611397

RXRG
Retinoic acid receptor RXR-gamma

1

20

Small-scale

0.647

High

611537

NCOA3
Nuclear receptor coactivator 3

1

20

Small-scale

0.647

High

386100

P53
Cellular tumor antigen p53

2

7

Small-scale

0.639

High

611454

MIDN
Midnolin

3

0

High-throughput

0.638

High

611536

NCOR2
Nuclear receptor corepressor 2

2

20

Small-scale

0.631

High

611459

ACD11
Acyl-CoA dehydrogenase family member 11

2

8

High-throughput

0.628

High

611407

CDN2D
Cyclin-dependent kinase 4 inhibitor D

2

20

High-throughput

0.628

High

238631

IMA7
Importin subunit alpha-7

1

9

Small-scale

0.618

High

611373

NR4A1
Nuclear receptor subfamily 4immunitygroup A member 1

1

19

Small-scale

0.618

High

611404

IMA5
Importin subunit alpha-5

1

9

Small-scale

0.618

High

611445

NCOA2
Nuclear receptor coactivator 2

1

20

Small-scale

0.618

High

611396

MK08
Mitogen-activated protein kinase 8

2

18

Small-scale

0.602

High

611423

EP300
Histone acetyltransferase p300

2

20

Small-scale

0.602

High

611449

MK14
Mitogen-activated protein kinase 14

1

18

Small-scale

0.598

High

611429

PRDX4
Peroxiredoxin-4

2

8

High-throughput

0.595

High

611509

ROBO2
Roundabout homolog 2

1

4

High-throughput

0.587

High

611420

SMAD3
Mothers against decapentaplegic homolog 3

2

12

Small-scale

0.586

High

162408

XPO1
Exportin-1

2

9

Small-scale

0.584

High

242811

TRI13
E3 ubiquitin-protein ligase TRIM13

2

15

Small-scale

0.584

High

611436

SQSTM
Sequestosome-1

2

9

Small-scale

0.584

High

611443

CHD4
Chromodomain-helicase-DNA-binding protein 4

2

20

Small-scale

0.584

High

611482

SMRC1
SWI/SNF complex subunit SMARCC1

2

20

Small-scale

0.584

High

611485

SMCE1
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1

2

15

Small-scale

0.584

High

225178

BNI3L
BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like

1

2

Small-scale

0.578

High

381124

TBB4A
Tubulin beta-4A chain

1

15

High-throughput

0.578

High

611400

VASP
Vasodilator-stimulated phosphoprotein

1

11

High-throughput

0.578

High

611519

AKIB1
Ankyrin repeat and IBR domain-containing protein 1

1

6

High-throughput

0.578

High

611395

GRK6
G protein-coupled receptor kinase 6

2

15

High-throughput

0.574

High

611456

TMTC4
Protein O-mannosyl-transferase TMTC4

2

15

High-throughput

0.574

High

611381

GLPK
Glycerol kinase

1

2

High-throughput

0.573

High

611391

STAT3
Signal transducer and activator of transcription 3

1

19

High-throughput

0.573

High

611452

LONF1
LON peptidase N-terminal domain and RING finger protein 1

1

20

High-throughput

0.573

High

611376

PML
Protein PML

1

20

Small-scale

0.561

High

611379

AKT1
RAC-alpha serine/threonine-protein kinase

1

17

Small-scale

0.561

High

611390

VHL
von Hippel-Lindau disease tumor suppressor

1

3

Small-scale

0.561

High

611421

TF65
Transcription factor p65

1

20

Small-scale

0.561

High

611426

TRAF2
TNF receptor-associated factor 2

1

17

Small-scale

0.561

High

611433

TIF1B
Transcription intermediary factor 1-beta

1

20

Small-scale

0.561

High

611476

NDRG1
Protein NDRG1

1

1

Small-scale

0.561

High

611384

PPM1A
Protein phosphatase 1A

1

2

High-throughput

0.541

High

611435

ATM
Serine-protein kinase ATM

1

14

High-throughput

0.541

High

611521

KS6A6
Ribosomal protein S6 kinase alpha-6

1

17

High-throughput

0.541

High

611496

ANM1
Protein arginine N-methyltransferase 1

1

17

Small-scale

0.534

High

611450

B2LA1
Bcl-2-related protein A1

1

7

Small-scale

0.515

High

611410

KR105
Keratin-associated protein 10-5

1

14

High-throughput

0.515

High

611389

IFI27
Interferon alpha-inducible protein 27, mitochondrial

1

0

Small-scale

0.511

High

166497

NACAD
NAC-alpha domain-containing protein 1

1

20

High-throughput

0.508

High

364040

CXCL7
Platelet basic protein

1

2

High-throughput

0.508

High

437901

HS90B
Heat shock protein HSP 90-beta

1

20

High-throughput

0.508

High

551067

ITF2
Transcription factor 4

1

1

High-throughput

0.508

High

574917

RL7
Large ribosomal subunit protein uL30

1

4

High-throughput

0.508

High

609714

ROA2
Heterogeneous nuclear ribonucleoproteins A2/B1

1

20

High-throughput

0.508

High

611405

ATX1
Ataxin-1

1

2

High-throughput

0.508

High

611425

CHD3
Chromodomain-helicase-DNA-binding protein 3

1

20

High-throughput

0.508

High

611440

HES1
Transcription factor HES-1

1

3

High-throughput

0.508

High

611467

ZN579
Zinc finger protein 579

1

14

High-throughput

0.508

High

611511

RTN4
Reticulon-4

1

7

High-throughput

0.508

High

611512

ZN331
Zinc finger protein 331

1

11

High-throughput

0.508

High

611525

FAF1
FAS-associated factor 1

1

6

High-throughput

0.508

High

611535

CD2AP
CD2-associated protein

1

11

High-throughput

0.508

High

611432

M3K1
Mitogen-activated protein kinase kinase kinase 1

1

7

Small-scale

0.501

High

611448

STK11
Serine/threonine-protein kinase STK11

1

3

Small-scale

0.501

High

611480

KAT2B
Histone acetyltransferase KAT2B

1

20

Small-scale

0.501

High

611442

FXYD3
FXYD domain-containing ion transport regulator 3

1

1

High-throughput

0.494

High

611510

B2L10
Bcl-2-like protein 10

1

0

Small-scale

0.493

High

611439

DPOA2
DNA polymerase alpha subunit B

1

0

High-throughput

0.486

High

611506

GLOD4
Glyoxalase domain-containing protein 4

1

0

High-throughput

0.486

High

611531

MED31
Mediator of RNA polymerase II transcription subunit 31

1

0

High-throughput

0.486

High

309778

MRP6
ATP-binding cassette sub-family C member 6

1

7

High-throughput

0.481

High

331211

CHK2
Serine/threonine-protein kinase Chk2

1

14

High-throughput

0.481

High

587417

NFKB1
Nuclear factor NF-kappa-B p105 subunit

1

20

High-throughput

0.481

High

611375

RBL1
Retinoblastoma-like protein 1

1

3

High-throughput

0.481

High

611378

PRDX6
Peroxiredoxin-6

1

13

High-throughput

0.481

High

611392

ECHA
Trifunctional enzyme subunit alpha, mitochondrial

1

5

High-throughput

0.481

High

611399

CPT1A
Carnitine O-palmitoyltransferase 1, liver isoform

1

3

High-throughput

0.481

High

611409

KR101
Keratin-associated protein 10-1

1

15

High-throughput

0.481

High

611424

ARHG5
Rho guanine nucleotide exchange factor 5

1

20

High-throughput

0.481

High

611463

CHD1L
Chromodomain-helicase-DNA-binding protein 1-like

1

20

High-throughput

0.481

High

611530

SGT1
Protein SGT1 homolog

1

12

High-throughput

0.481

High

133881

DDX3X
ATP-dependent RNA helicase DDX3X

1

11

Small-scale

0.479

High

167332

SMAD7
Mothers against decapentaplegic homolog 7

1

12

Small-scale

0.479

High

195343

DHX15
ATP-dependent RNA helicase DHX15

1

11

Small-scale

0.479

High

197227

SERA
D-3-phosphoglycerate dehydrogenase

1

7

Small-scale

0.479

High

198181

SEPT4
Septin-4

1

10

High-throughput

0.479

High

202058

HNRPR
Heterogeneous nuclear ribonucleoprotein R

1

16

Small-scale

0.479

High

215317

U3IP2
U3 small nucleolar RNA-interacting protein 2

1

20

Small-scale

0.479

High

215583

AKAP8
A-kinase anchor protein 8

1

9

Small-scale

0.479

High

235711

HNRPQ
Heterogeneous nuclear ribonucleoprotein Q

1

16

Small-scale

0.479

High

242358

DKC1
H/ACA ribonucleoprotein complex subunit DKC1

1

1

Small-scale

0.479

High

254872

CPNE3
Copine-3

1

2

Small-scale

0.479

High

277936

PIAS1
E3 SUMO-protein ligase PIAS1

1

16

Small-scale

0.479

High

278228

PIAS2
E3 SUMO-protein ligase PIAS2

1

16

Small-scale

0.479

High

295934

MTA2
Metastasis-associated protein MTA2

1

20

Small-scale

0.479

High

314003

BAG4
BAG family molecular chaperone regulator 4

1

2

Small-scale

0.479

High

318572

EYA4
Eyes absent homolog 4

1

18

Small-scale

0.479

High

322187

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

20

Small-scale

0.479

High

402691

FABPH
Fatty acid-binding protein, heart

1

9

High-throughput

0.479

High

422486

CENPB
Major centromere autoantigen B

1

5

High-throughput

0.479

High

423142

PDIA1
Protein disulfide-isomerase

1

9

Small-scale

0.479

High

443331

VIME
Vimentin

1

20

Small-scale

0.479

High

488904

H14
Histone H1.4

1

5

Small-scale

0.479

High

500720

CLUS
Clusterin

1

3

High-throughput

0.479

High

501682

BIP
Endoplasmic reticulum chaperone BiP

1

19

Small-scale

0.479

High

503444

HSP7C
Heat shock cognate 71 kDa protein

1

15

Small-scale

0.479

High

508823

TOP2A
DNA topoisomerase 2-alpha

1

7

Small-scale

0.479

High

516359

PABP1
Polyadenylate-binding protein 1

1

17

Small-scale

0.479

High

518086

ADT1
ADP/ATP translocase 1

1

12

Small-scale

0.479

High

518583

IMDH2
Inosine-5'-monophosphate dehydrogenase 2

1

2

Small-scale

0.479

High

524794

XRCC5
X-ray repair cross-complementing protein 5

1

11

Small-scale

0.479

High

538103

ENPL
Endoplasmin

1

20

High-throughput

0.479

High

540897

HNRPL
Heterogeneous nuclear ribonucleoprotein L

1

20

Small-scale

0.479

High

559553

H12
Histone H1.2

1

5

Small-scale

0.479

High

571310

DDX5
Probable ATP-dependent RNA helicase DDX5

1

12

Small-scale

0.479

High

573130

TCPA
T-complex protein 1 subunit alpha

1

10

Small-scale

0.479

High

575271

EGR1
Early growth response protein 1

1

12

Small-scale

0.479

High

611374

PTBP1
Polypyrimidine tract-binding protein 1

1

20

Small-scale

0.479

High

611380

HNRH1
Heterogeneous nuclear ribonucleoprotein H

1

20

Small-scale

0.479

High

611383

PCKGC
Phosphoenolpyruvate carboxykinase, cytosolic [GTP]

1

3

Small-scale

0.479

High

611385

K22E
Keratin, type II cytoskeletal 2 epidermal

1

19

Small-scale

0.479

High

611387

GRP75
Stress-70 protein, mitochondrial

1

20

Small-scale

0.479

High

611388

TCPZ
T-complex protein 1 subunit zeta

1

10

Small-scale

0.479

High

611394

MATR3
Matrin-3

1

11

High-throughput

0.479

High

611401

SMCA2
Probable global transcription activator SNF2L2

1

20

Small-scale

0.479

High

611402

SMCA4
Transcription activator BRG1

1

20

Small-scale

0.479

High

611403

HNRPM
Heterogeneous nuclear ribonucleoprotein M

1

18

Small-scale

0.479

High

611406

TERF1
Telomeric repeat-binding factor 1

1

2

High-throughput

0.479

High

611408

HNRH2
Heterogeneous nuclear ribonucleoprotein H2

1

20

Small-scale

0.479

High

611411

PRS4
26S proteasome regulatory subunit 4

1

20

Small-scale

0.479

High

611412

PRS8
26S proteasome regulatory subunit 8

1

20

High-throughput

0.479

High

611413

H4
Histone H4

1

3

High-throughput

0.479

High

611414

YBOX1
Y-box-binding protein 1

1

5

Small-scale

0.479

High

611415

EF1A1
Elongation factor 1-alpha 1

1

10

Small-scale

0.479

High

611417

CSK21
Casein kinase II subunit alpha

1

7

Small-scale

0.479

High

611418

RNF4
E3 ubiquitin-protein ligase RNF4

1

5

Small-scale

0.479

High

611419

TCPB
T-complex protein 1 subunit beta

1

13

Small-scale

0.479

High

611422

LG3BP
Galectin-3-binding protein

1

5

Small-scale

0.479

High

611427

STK4
Serine/threonine-protein kinase 4

1

18

Small-scale

0.479

High

611428

CACO2
Calcium-binding and coiled-coil domain-containing protein 2

1

20

Small-scale

0.479

High

611430

STK3
Serine/threonine-protein kinase 3

1

11

Small-scale

0.479

High

611431

NMDE2
Glutamate receptor ionotropic, NMDA 2B

1

2

Small-scale

0.479

High

611434

PABP4
Polyadenylate-binding protein 4

1

17

Small-scale

0.479

High

611437

HDAC1
Histone deacetylase 1

1

20

Small-scale

0.479

High

611438

KEAP1
Kelch-like ECH-associated protein 1

1

3

Small-scale

0.479

High

611441

LBR
Delta(14)-sterol reductase LBR

1

3

Small-scale

0.479

High

611444

NONO
Non-POU domain-containing octamer-binding protein

1

20

Small-scale

0.479

High

611446

TAB1
TGF-beta-activated kinase 1 and MAP3K7-binding protein 1

1

6

Small-scale

0.479

High

611451

HIF1A
Hypoxia-inducible factor 1-alpha

1

20

Small-scale

0.479

High

611453

PPCEL
Prolyl endopeptidase-like

1

2

High-throughput

0.479

High

611455

ZN326
DBIRD complex subunit ZNF326

1

9

Small-scale

0.479

High

611457

SMRD3
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 3

1

20

Small-scale

0.479

High

611458

RN111
E3 ubiquitin-protein ligase Arkadia

1

14

Small-scale

0.479

High

611460

TBA1A
Tubulin alpha-1A chain

1

19

Small-scale

0.479

High

611461

YTHD3
YTH domain-containing family protein 3

1

9

Small-scale

0.479

High

611465

PELP1
Proline-, glutamic acid- and leucine-rich protein 1

1

20

Small-scale

0.479

High

611466

CPSF7
Cleavage and polyadenylation specificity factor subunit 7

1

15

Small-scale

0.479

High

611468

FA98A
Protein FAM98A

1

2

Small-scale

0.479

High

611469

G45IP
Large ribosomal subunit protein mL64

1

1

Small-scale

0.479

High

611471

SMRC2
SWI/SNF complex subunit SMARCC2

1

20

Small-scale

0.479

High

611472

PHIP
PH-interacting protein

1

20

High-throughput

0.479

High

611473

PRP31
U4/U6 small nuclear ribonucleoprotein Prp31

1

7

Small-scale

0.479

High

611477

HS105
Heat shock protein 105 kDa

1

20

High-throughput

0.479

High

611478

TFG
Protein TFG

1

12

Small-scale

0.479

High

611479

RBP56
TATA-binding protein-associated factor 2N

1

17

Small-scale

0.479

High

611481

RENT1
Regulator of nonsense transcripts 1

1

11

Small-scale

0.479

High

611483

SMRD2
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2

1

20

Small-scale

0.479

High

611484

FUBP2
Far upstream element-binding protein 2

1

16

Small-scale

0.479

High

611487

OTUB2
Ubiquitin thioesterase OTUB2

1

2

Small-scale

0.479

High

611489

OTUB1
Ubiquitin thioesterase OTUB1

1

2

Small-scale

0.479

High

611490

SMRD1
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1

1

20

Small-scale

0.479

High

611491

FUBP3
Far upstream element-binding protein 3

1

16

Small-scale

0.479

High

611494

EYA1
Eyes absent homolog 1

1

20

Small-scale

0.479

High

611495

TCPH
T-complex protein 1 subunit eta

1

12

Small-scale

0.479

High

611497

GRWD1
Glutamate-rich WD repeat-containing protein 1

1

20

Small-scale

0.479

High

611498

MBB1A
Myb-binding protein 1A

1

3

Small-scale

0.479

High

611499

HNRL1
Heterogeneous nuclear ribonucleoprotein U-like protein 1

1

20

Small-scale

0.479

High

611500

NUSAP
Nucleolar and spindle-associated protein 1

1

1

Small-scale

0.479

High

611502

ESF1
ESF1 homolog

1

3

High-throughput

0.479

High

611504

SMUF2
E3 ubiquitin-protein ligase SMURF2

1

10

Small-scale

0.479

High

611505

PATZ1
POZ-, AT hook-, and zinc finger-containing protein 1

1

18

Small-scale

0.479

High

611507

MCCB
Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial

1

4

Small-scale

0.479

High

611514

STAU2
Double-stranded RNA-binding protein Staufen homolog 2

1

20

Small-scale

0.479

High

611515

DD19A
ATP-dependent RNA helicase DDX19A

1

20

Small-scale

0.479

High

611516

RNF12
E3 ubiquitin-protein ligase RLIM

1

11

Small-scale

0.479

High

611518

FAKD2
FAST kinase domain-containing protein 2, mitochondrial

1

3

Small-scale

0.479

High

611520

HDAC6
Histone deacetylase 6

1

20

Small-scale

0.479

High

611522

AGO2
Protein argonaute-2

1

2

Small-scale

0.479

High

611523

MYT1L
Myelin transcription factor 1-like protein

1

5

High-throughput

0.479

High

611526

TNR6B
Trinucleotide repeat-containing gene 6B protein

1

9

Small-scale

0.479

High

611527

CHM2B
Charged multivesicular body protein 2b

1

3

High-throughput

0.479

High

611528

AXIN2
Axin-2

1

3

Small-scale

0.479

High

611529

YBOX2
Y-box-binding protein 2

1

5

Small-scale

0.479

High

611532

RTCB
RNA-splicing ligase RtcB homolog

1

2

Small-scale

0.479

High

611533

DCAF1
DDB1- and CUL4-associated factor 1

1

15

High-throughput

0.479

High

611538

PIAS3
E3 SUMO-protein ligase PIAS3

1

16

Small-scale

0.479

High

611377

KAIN
Kallistatin

1

7

High-throughput

0.464

High

611534

PLXD1
Plexin-D1

1

5

Small-scale

0.462

High

335048

DHE3
Glutamate dehydrogenase 1, mitochondrial

1

0

High-throughput

0.460

High

611501

ABCG8
ATP-binding cassette sub-family G member 8

1

0

High-throughput

0.460

High

611513

DBLOH
Diablo IAP-binding mitochondrial protein

1

0

High-throughput

0.460

High

195627

MCES
mRNA cap guanine-N7 methyltransferase

1

0

Small-scale

0.458

High

537802

KPYM
Pyruvate kinase PKM

1

0

Small-scale

0.458

High

611393

ID1
DNA-binding protein inhibitor ID-1

1

0

Small-scale

0.458

High

611488

ESS2
Splicing factor ESS-2 homolog

1

0

Small-scale

0.458

High

611493

CRBN
Protein cereblon

1

0

Small-scale

0.458

High

611508

ARGAL
Rho guanine nucleotide exchange factor 10-like protein

1

20

High-throughput

0.457

High

311430

ABCBB
Bile salt export pump

1

4

High-throughput

0.439

High

397683

IC1
Plasma protease C1 inhibitor

1

9

High-throughput

0.439

High

611398

LSS
Lanosterol synthase

1

1

High-throughput

0.439

High

611474

ABCA5
Cholesterol transporter ABCA5

1

4

High-throughput

0.439

High

611475

SOCS4
Suppressor of cytokine signaling 4

1

19

High-throughput

0.439

High

280019

MPDZ
Multiple PDZ domain protein

1

20

High-throughput

0.437

High

611416

TBA1B
Tubulin alpha-1B chain

1

19

Small-scale

0.437

High

611462

PRP39
Pre-mRNA-processing factor 39

1

13

Small-scale

0.437

High

611464

RB6I2
ELKS/Rab6-interacting/CAST family member 1

1

20

High-throughput

0.437

High

611486

CCD47
PAT complex subunit CCDC47

1

3

Small-scale

0.437

High

611503

NT5D2
5'-nucleotidase domain-containing protein 2

1

2

Small-scale

0.437

High

611517

TMOD3
Tropomodulin-3

1

8

Small-scale

0.437

High

611524

PCDGK
Protocadherin gamma-C3

1

1

High-throughput

0.437

High

245155

CUTA
Protein CutA

1

0

High-throughput

0.301

High

611470

BBS10
Bardet-Biedl syndrome 10 protein

1

0

High-throughput

0.265

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024