Protein: EHMT1
Histone-lysine N-methyltransferase EHMT1 (EC 2.1.1.-) (EC 2.1.1.367) (Euchromatic histone-lysine N-methyltransferase 1) (Eu-HMTase1) (G9a-like protein 1) (GLP) (GLP1) (Histone H3-K9 methyltransferase 5) (H3-K9-HMTase 5) (Lysine N-methyltransferase 1D)

Gene: EHMT1
Organism: Homo sapiens
Interactions: 157
UniProt ID: Q9H9B1

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000785 - chromatin
GO:0001222 - transcription corepressor binding
GO:0002039 - p53 binding
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1396307

EHMT2
Histone-lysine N-methyltransferase EHMT2

7

18

Small-scale

0.963

High

998821

H31
Histone H3.1

6

20

Small-scale

0.931

High

1017218

H33
Histone H3.3

4

20

Small-scale

0.886

High

1405189

MPP8
M-phase phosphoprotein 8

3

14

Small-scale

0.875

High

216545

SUV91
Histone-lysine N-methyltransferase SUV39H1

3

15

Small-scale

0.861

High

1289778

ZBT46
Zinc finger and BTB domain-containing protein 46

3

7

High-throughput

0.861

High

1434601

SUV92
Histone-lysine N-methyltransferase SUV39H2

3

14

High-throughput

0.861

High

502133

H2AZ
Histone H2A.Z

2

7

High-throughput

0.811

High

227669

SPOP
Speckle-type POZ protein

2

2

Small-scale

0.800

High

1381865

H2B1A
Histone H2B type 1-A

2

9

High-throughput

0.789

High

414644

P53
Cellular tumor antigen p53

2

5

Small-scale

0.778

High

1045780

TF65
Transcription factor p65

1

3

Small-scale

0.770

High

1139842

SETB1
Histone-lysine N-methyltransferase SETDB1

2

14

Small-scale

0.767

High

980344

H4
Histone H4

2

3

High-throughput

0.754

High

1103383

CTBP1
C-terminal-binding protein 1

5

4

Small-scale

0.712

High

1110089

HDAC1
Histone deacetylase 1

4

14

High-throughput

0.704

High

1420531

TRI15
E3 ubiquitin-protein ligase TRIM15

1

4

High-throughput

0.698

High

502541

H2A1
Histone H2A type 1

1

4

High-throughput

0.691

High

625632

CSK22
Casein kinase II subunit alpha'

1

3

High-throughput

0.691

High

998032

CSK21
Casein kinase II subunit alpha

1

5

High-throughput

0.691

High

1163213

H2B2E
Histone H2B type 2-E

1

9

High-throughput

0.691

High

1014206

CBX1
Chromobox protein homolog 1

3

20

High-throughput

0.675

High

1395185

ZN462
Zinc finger protein 462

3

4

High-throughput

0.675

High

1097568

CBX3
Chromobox protein homolog 3

3

20

High-throughput

0.667

High

1324714

MIER2
Mesoderm induction early response protein 2

3

13

High-throughput

0.667

High

832803

BCL6
B-cell lymphoma 6 protein

1

0

Small-scale

0.656

High

1162047

H31T
Histone H3.1t

1

20

Small-scale

0.647

High

1436915

EHMT1
Histone-lysine N-methyltransferase EHMT1

1

15

Small-scale

0.647

High

853412

CBX5
Chromobox protein homolog 5

2

20

Small-scale

0.628

High

1368129

HDAC2
Histone deacetylase 2

2

14

High-throughput

0.628

High

1436930

LMBL1
Lethal(3)malignant brain tumor-like protein 1

2

5

High-throughput

0.628

High

1328763

LZTR1
Leucine-zipper-like transcriptional regulator 1

1

8

High-throughput

0.625

High

285480

EED
Polycomb protein EED

1

11

High-throughput

0.618

High

487766

PARP1
Poly [ADP-ribose] polymerase 1

1

11

High-throughput

0.618

High

832578

ETV3
ETS translocation variant 3

1

10

High-throughput

0.618

High

837091

ELK3
ETS domain-containing protein Elk-3

1

11

High-throughput

0.618

High

877564

LHX1
LIM/homeobox protein Lhx1

1

11

High-throughput

0.618

High

881609

CDK8
Cyclin-dependent kinase 8

1

8

High-throughput

0.618

High

883692

CENPA
Histone H3-like centromeric protein A

1

20

High-throughput

0.618

High

895800

LHX2
LIM/homeobox protein Lhx2

1

12

High-throughput

0.618

High

981106

H2B1C
Histone H2B type 1-C/E/F/G/I

1

9

High-throughput

0.618

High

1114326

CUL3
Cullin-3

1

10

High-throughput

0.618

High

1152745

ELF2
ETS-related transcription factor Elf-2

1

9

High-throughput

0.618

High

1155781

EZH2
Histone-lysine N-methyltransferase EZH2

1

18

High-throughput

0.618

High

1314425

SLX4
Structure-specific endonuclease subunit SLX4

1

9

High-throughput

0.618

High

1328959

ZBTB2
Zinc finger and BTB domain-containing protein 2

1

3

High-throughput

0.618

High

1338970

NUP43
Nucleoporin Nup43

1

13

High-throughput

0.618

High

1379950

LHX4
LIM/homeobox protein Lhx4

1

11

High-throughput

0.618

High

1405437

FEV
Protein FEV

1

8

High-throughput

0.618

High

1436922

LHX3
LIM/homeobox protein Lhx3

1

11

High-throughput

0.618

High

1436928

ELF5
ETS-related transcription factor Elf-5

1

9

High-throughput

0.618

High

1436931

TRRAP
Transformation/transcription domain-associated protein

1

3

High-throughput

0.618

High

345007

WIZ
Protein Wiz

2

10

High-throughput

0.611

High

1434493

ZN644
Zinc finger protein 644

2

10

High-throughput

0.611

High

897397

CDK7
Cyclin-dependent kinase 7

1

0

High-throughput

0.586

High

143264

NFIB
Nuclear factor 1 B-type

2

7

High-throughput

0.584

High

474300

NFIC
Nuclear factor 1 C-type

2

10

High-throughput

0.584

High

1088028

NFIA
Nuclear factor 1 A-type

2

8

High-throughput

0.584

High

1100395

TIF1B
Transcription intermediary factor 1-beta

2

9

High-throughput

0.584

High

1133669

NFIX
Nuclear factor 1 X-type

2

9

High-throughput

0.584

High

1355883

XAGE3
X antigen family member 3

2

9

High-throughput

0.574

High

1392386

XAGE2
X antigen family member 2

2

9

High-throughput

0.574

High

396973

ESR1
Estrogen receptor

2

19

High-throughput

0.571

High

886323

ARL4D
ADP-ribosylation factor-like protein 4D

1

8

High-throughput

0.553

High

961642

PHS
Pterin-4-alpha-carbinolamine dehydratase

1

1

High-throughput

0.541

High

168056

RGS12
Regulator of G-protein signaling 12

1

4

High-throughput

0.536

High

1099786

MD2L1
Mitotic spindle assembly checkpoint protein MAD2A

1

3

High-throughput

0.536

High

1134730

NUMA1
Nuclear mitotic apparatus protein 1

1

10

High-throughput

0.536

High

1329877

SIR6
NAD-dependent protein deacylase sirtuin-6

1

7

High-throughput

0.536

High

1436916

COPRS
Coordinator of PRMT5 and differentiation stimulator

1

1

High-throughput

0.536

High

1436919

HIF1N
Hypoxia-inducible factor 1-alpha inhibitor

1

11

High-throughput

0.536

High

927555

ATX1
Ataxin-1

1

0

High-throughput

0.518

High

284353

GEMI
Geminin

1

0

High-throughput

0.513

High

1353788

HASP
Serine/threonine-protein kinase haspin

1

0

High-throughput

0.513

High

617464

DNLI1
DNA ligase 1

1

7

Small-scale

0.501

High

964459

SUMO2
Small ubiquitin-related modifier 2

1

2

High-throughput

0.501

High

1436934

DNM3A
DNA

1

8

Small-scale

0.501

High

1407366

NKX31
Homeobox protein Nkx-3.1

1

15

Small-scale

0.500

High

890261

TIG1
Retinoic acid receptor responder protein 1

1

1

High-throughput

0.489

High

1196250

GAG2E
G antigen 2E

1

7

High-throughput

0.489

High

1436924

GGE2D
G antigen 2D

1

7

High-throughput

0.489

High

129443

MEN1
Menin

1

2

High-throughput

0.479

High

191098

RPA34
DNA-directed RNA polymerase I subunit RPA34

1

8

High-throughput

0.479

High

210119

CRX
Cone-rod homeobox protein

1

12

High-throughput

0.479

High

225114

TLX3
T-cell leukemia homeobox protein 3

1

19

High-throughput

0.479

High

226601

TLX2
T-cell leukemia homeobox protein 2

1

15

High-throughput

0.479

High

240000

SOX15
Transcription factor SOX-15

1

10

High-throughput

0.479

High

260471

BRD4
Bromodomain-containing protein 4

1

8

High-throughput

0.479

High

339861

KLF8
Krueppel-like factor 8

1

20

High-throughput

0.479

High

373173

MYC
Myc proto-oncogene protein

1

10

Small-scale

0.479

High

404432

GCR
Glucocorticoid receptor

1

20

High-throughput

0.479

High

519423

MYB
Transcriptional activator Myb

1

4

High-throughput

0.479

High

581730

MYOD1
Myoblast determination protein 1

1

8

High-throughput

0.479

High

607114

CEBPB
CCAAT/enhancer-binding protein beta

1

5

High-throughput

0.479

High

662501

GATA2
Endothelial transcription factor GATA-2

1

3

High-throughput

0.479

High

674337

BRD2
Bromodomain-containing protein 2

1

11

High-throughput

0.479

High

675687

TYY1
Transcriptional repressor protein YY1

1

7

High-throughput

0.479

High

685066

DNMT1
DNA

1

19

Small-scale

0.479

High

685351

PAX6
Paired box protein Pax-6

1

3

High-throughput

0.479

High

697258

APEX1
DNA repair nuclease/redox regulator APEX1

1

1

High-throughput

0.479

High

703201

TEAD1
Transcriptional enhancer factor TEF-1

1

1

High-throughput

0.479

High

725321

TLX1
T-cell leukemia homeobox protein 1

1

20

High-throughput

0.479

High

765897

BMI1
Polycomb complex protein BMI-1

1

3

High-throughput

0.479

High

800108

COIL
Coilin

1

1

High-throughput

0.479

High

834057

HNF4A
Hepatocyte nuclear factor 4-alpha

1

15

High-throughput

0.479

High

872755

SOX2
Transcription factor SOX-2

1

10

High-throughput

0.479

High

887233

CEBPA
CCAAT/enhancer-binding protein alpha

1

4

High-throughput

0.479

High

905153

MECP2
Methyl-CpG-binding protein 2

1

9

High-throughput

0.479

High

941567

CTBP2
C-terminal-binding protein 2

1

4

Small-scale

0.479

High

944745

KLF3
Krueppel-like factor 3

1

18

High-throughput

0.479

High

995276

CSK2B
Casein kinase II subunit beta

1

2

High-throughput

0.479

High

1028399

MDM2
E3 ubiquitin-protein ligase Mdm2

1

3

Small-scale

0.479

High

1032049

TFAP4
Transcription factor AP-4

1

1

Small-scale

0.479

High

1037820

IRF8
Interferon regulatory factor 8

1

4

High-throughput

0.479

High

1037900

HEN1
Helix-loop-helix protein 1

1

4

High-throughput

0.479

High

1094739

CAF1A
Chromatin assembly factor 1 subunit A

1

9

High-throughput

0.479

High

1094817

CAF1B
Chromatin assembly factor 1 subunit B

1

4

High-throughput

0.479

High

1107221

BIRC3
Baculoviral IAP repeat-containing protein 3

1

1

High-throughput

0.479

High

1132984

CHD4
Chromodomain-helicase-DNA-binding protein 4

1

6

High-throughput

0.479

High

1141316

BRD3
Bromodomain-containing protein 3

1

9

High-throughput

0.479

High

1204396

SGO1
Shugoshin 1

1

1

High-throughput

0.479

High

1217764

GFI1B
Zinc finger protein Gfi-1b

1

8

Small-scale

0.479

High

1240779

PMF1
Polyamine-modulated factor 1

1

1

High-throughput

0.479

High

1276806

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

7

High-throughput

0.479

High

1277241

POGZ
Pogo transposable element with ZNF domain

1

6

High-throughput

0.479

High

1351165

SP7
Transcription factor Sp7

1

15

High-throughput

0.479

High

1361238

DNJC9
DnaJ homolog subfamily C member 9

1

5

High-throughput

0.479

High

1369253

JARD2
Protein Jumonji

1

2

Small-scale

0.479

High

1371696

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

1

8

Small-scale

0.479

High

1394506

NSL1
Kinetochore-associated protein NSL1 homolog

1

1

High-throughput

0.479

High

1395211

CHAP1
Chromosome alignment-maintaining phosphoprotein 1

1

14

High-throughput

0.479

High

1401396

CIC
Protein capicua homolog

1

17

High-throughput

0.479

High

1416913

KLF16
Krueppel-like factor 16

1

14

High-throughput

0.479

High

1428628

RPA49
DNA-directed RNA polymerase I subunit RPA49

1

1

High-throughput

0.479

High

1429542

MIS12
Protein MIS12 homolog

1

1

High-throughput

0.479

High

1433044

DSN1
Kinetochore-associated protein DSN1 homolog

1

1

High-throughput

0.479

High

1433844

SMRCD
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1

1

5

High-throughput

0.479

High

1436917

PRDM6
Putative histone-lysine N-methyltransferase PRDM6

1

4

Small-scale

0.479

High

1436920

TLS1
Splicing factor C9orf78

1

1

High-throughput

0.479

High

1436921

VSX1
Visual system homeobox 1

1

11

High-throughput

0.479

High

1436923

ZMYM2
Zinc finger MYM-type protein 2

1

2

High-throughput

0.479

High

1436925

LRWD1
Leucine-rich repeat and WD repeat-containing protein 1

1

1

Small-scale

0.479

High

1436927

KLF15
Krueppel-like factor 15

1

17

High-throughput

0.479

High

1436932

KLF12
Krueppel-like factor 12

1

16

High-throughput

0.479

High

1436933

CDY2
Testis-specific chromodomain protein Y 2

1

7

High-throughput

0.479

High

1436929

ZN330
Zinc finger protein 330

1

0

High-throughput

0.458

High

843994

HD
Huntingtin

1

1

High-throughput

0.457

High

1404409

CDC5L
Cell division cycle 5-like protein

1

4

High-throughput

0.445

High

1436926

MD2L2
Mitotic spindle assembly checkpoint protein MAD2B

1

3

Small-scale

0.445

High

346350

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

5

High-throughput

0.437

High

391778

PRPC
Salivary acidic proline-rich phosphoprotein 1/2

1

7

High-throughput

0.437

High

1428362

MLP3B
Microtubule-associated protein 1 light chain 3 beta

1

12

High-throughput

0.437

High

1278638

HEAT3
HEAT repeat-containing protein 3

1

0

High-throughput

0.279

Low

1436918

ABHDA
Palmitoyl-protein thioesterase ABHD10, mitochondrial

1

0

High-throughput

0.279

Low

518791

IL8
Interleukin-8

1

0

Small-scale

0.249

Low

1358110

NUDC2
NudC domain-containing protein 2

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025