HitPredict

Interactor 1: Q59GT1 (Q59GT1)
Inhibitor of nuclear factor kappa-B kinase subunit alpha (EC 2.7.11.10) (Nuclear factor NF-kappa-B inhibitor kinase alpha)
Gene: Q59GT1

Interactor 2: Q9BPW0 (Q9BPW0)
Serine/threonine-protein phosphatase (EC 3.1.3.16)
Gene: PPP5C

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.50	0.437

Property	Details
Experiments	25036637
Identification Methods	luminescence based mammalian interactome mapping
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 726 Hs			1 484
+	Hs
		167515 IKKA_HUMAN (8-710): 0: 587: 100.00		PP2AA_HUMAN (188-483): 3.01e-169: 480: 40.33
+	Hs
		167506 IKKA_HUMAN (8-710): 0: 587: 100.00		PP4C_HUMAN (185-483): 1.17e-165: 471: 39.33
+	Hs
		158442 IKKB_HUMAN (8-697): 0: 561: 52.14		PP2AA_HUMAN (188-483): 3.01e-169: 480: 40.33
+	Hs
		158435 IKKB_HUMAN (8-697): 0: 561: 52.14		PP4C_HUMAN (185-483): 1.17e-165: 471: 39.33
+	Hs
		167511 IKKA_HUMAN (8-710): 0: 587: 100.00		PP2AB_HUMAN (190-483): 3.71e-154: 442: 39.32
+	Hs
		167510 IKKA_HUMAN (8-710): 0: 587: 100.00		PP1A_HUMAN (196-479): 3.63e-152: 438: 38.25
+	Hs
		158438 IKKB_HUMAN (8-697): 0: 561: 52.14		PP1A_HUMAN (196-479): 3.63e-152: 438: 38.25
+	Mm
		291448 IKKB_MOUSE (8-697): 0: 557: 50.29		PP1A_MOUSE (196-479): 1.86e-152: 438: 38.25
+	Hs
		858663 M3K5_HUMAN (21-698): 2.88e-128: 415: 19.26		PPP5_HUMAN (1-482): 0: 546: 99.17
+	Hs
		1123965 Q59GL9_HUMAN (74-521): 2.14e-130: 396: 56.73		Q9BPW0_HUMAN (1-484): 0: 546: 100.00
+	Dm
		1359353 Q9V3Y8_DROME (27-660): 5.09e-112: 357: 18.68		Q9VH81_DROME (2-482): 1.01e-173: 500: 59.79
+	Hs
		625340 CDK2_HUMAN (19-319): 1.61e-125: 377: 22.98		PP2AA_HUMAN (188-483): 3.01e-169: 480: 40.33
+	Hs
		647866 MARK3_HUMAN (15-654): 6.99e-126: 394: 16.67		PP2AB_HUMAN (190-483): 3.71e-154: 442: 39.32
+	Hs
		931029 KS6B2_HUMAN (22-422): 4.14e-112: 349: 21.45		PP2AA_HUMAN (188-483): 3.01e-169: 480: 40.33
+	Mm
		956533 TBK1_MOUSE (22-514): 8.96e-109: 348: 23.12		PP4C_MOUSE (185-483): 1.17e-165: 471: 39.33
+	Hs
		625300 CDK2_HUMAN (19-319): 1.61e-125: 377: 22.98		PP1B_HUMAN (194-482): 2.2e-153: 441: 36.90
+	Hs
		625180 CDK2_HUMAN (19-319): 1.61e-125: 377: 22.98		PP1G_HUMAN (195-481): 2.06e-152: 438: 37.85
+	Hs
		625299 CDK2_HUMAN (19-319): 1.61e-125: 377: 22.98		PP1A_HUMAN (196-479): 3.63e-152: 438: 38.25
+	Hs
		890962 IKKE_HUMAN (22-618): 2.17e-90: 299: 21.46		PP4C_HUMAN (185-483): 1.17e-165: 471: 39.33
+	Hs
		915188 IKKE_HUMAN (22-618): 2.17e-90: 299: 21.46		PP2AB_HUMAN (190-483): 3.71e-154: 442: 39.32