Protein: TRI69
E3 ubiquitin-protein ligase TRIM69 (EC 2.3.2.27) (RFP-like domain-containing protein trimless) (RING finger protein 36) (RING-type E3 ubiquitin transferase TRIM69) (Tripartite motif-containing protein 69)

Gene: TRI69, TRIM69
Organism: Homo sapiens
Interactions: 122
UniProt ID: Q86WT6

Gene Ontology (top 5):
GO:0004842 - ubiquitin-protein transferase activity
GO:0005634 - nucleus
GO:0005737 - cytoplasm
GO:0005813 - centrosome
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1292720

TRI69
E3 ubiquitin-protein ligase TRIM69

3

16

High-throughput

0.867

High

996422

FKB1B
Peptidyl-prolyl cis-trans isomerase FKBP1B

3

0

High-throughput

0.827

High

1292745

TRIM4
E3 ubiquitin-protein ligase TRIM4

2

16

High-throughput

0.811

High

1292752

TRIM1
Probable E3 ubiquitin-protein ligase MID2

2

18

High-throughput

0.783

High

848335

MAGA4
Melanoma-associated antigen 4

7

9

High-throughput

0.744

High

469303

ASNS
Asparagine synthetase [glutamine-hydrolyzing]

4

2

High-throughput

0.698

High

1292732

HAUS1
HAUS augmin-like complex subunit 1

3

1

High-throughput

0.678

High

1286365

NEK8
Serine/threonine-protein kinase Nek8

3

5

High-throughput

0.675

High

1292739

F110A
Protein FAM110A

3

2

High-throughput

0.675

High

169632

HGS
Hepatocyte growth factor-regulated tyrosine kinase substrate

3

7

High-throughput

0.667

High

1292735

DTBP1
Dysbindin

3

1

High-throughput

0.667

High

1292740

FSP1
Ferroptosis suppressor protein 1

3

2

Small-scale

0.653

High

1088697

SF3A3
Splicing factor 3A subunit 3

2

1

High-throughput

0.633

High

62977

POTEF
POTE ankyrin domain family member F

2

12

High-throughput

0.628

High

1122934

WRN
Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN

1

5

Small-scale

0.618

High

1125148

TRI25
E3 ubiquitin/ISG15 ligase TRIM25

1

19

Small-scale

0.618

High

1292751

RSP14
Radial spoke head 14 homolog

3

10

High-throughput

0.616

High

301812

ANXA9
Annexin A9

2

3

High-throughput

0.612

High

933860

GEM
GTP-binding protein GEM

2

6

High-throughput

0.606

High

1180786

KLH38
Kelch-like protein 38

2

3

High-throughput

0.606

High

1185268

F161A
Protein FAM161A

2

4

High-throughput

0.606

High

1292736

NTAQ1
Protein N-terminal glutamine amidohydrolase

2

2

High-throughput

0.606

High

1292742

BEX2
Protein BEX2

2

1

High-throughput

0.606

High

1292747

BIN3
Bridging integrator 3

2

1

High-throughput

0.606

High

1292749

STMN3
Stathmin-3

2

1

High-throughput

0.606

High

1292750

WWOX
WW domain-containing oxidoreductase

2

1

High-throughput

0.606

High

1292753

RPC10
DNA-directed RNA polymerase III subunit RPC10

2

3

High-throughput

0.606

High

957123

UB2D3
Ubiquitin-conjugating enzyme E2 D3

2

20

Small-scale

0.602

High

333365

SNAPN
SNARE-associated protein Snapin

2

0

High-throughput

0.602

High

663428

RIR1
Ribonucleoside-diphosphate reductase large subunit

2

0

High-throughput

0.602

High

1246478

BL1S2
Biogenesis of lysosome-related organelles complex 1 subunit 2

2

0

High-throughput

0.602

High

352028

RECK
Reversion-inducing cysteine-rich protein with Kazal motifs

3

3

High-throughput

0.589

High

414136

P53
Cellular tumor antigen p53

2

5

Small-scale

0.584

High

852125

TNNT2
Troponin T, cardiac muscle

2

0

High-throughput

0.580

High

1156351

ETFD
Electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial

2

0

High-throughput

0.580

High

1238536

RINT1
RAD50-interacting protein 1

2

0

High-throughput

0.580

High

1292746

MED20
Mediator of RNA polymerase II transcription subunit 20

2

0

High-throughput

0.580

High

1047443

K1C17
Keratin, type I cytoskeletal 17

1

7

High-throughput

0.573

High

1150756

SF01
Splicing factor 1

1

2

High-throughput

0.573

High

1226021

LAR1B
La-related protein 1B

1

2

High-throughput

0.573

High

1239705

PPR18
Phostensin

1

5

High-throughput

0.573

High

1292734

TRI44
Tripartite motif-containing protein 44

1

16

High-throughput

0.573

High

341612

EYA4
Protein phosphatase EYA4

1

1

Small-scale

0.561

High

1243350

Q6P9E2
RECK protein

2

3

High-throughput

0.558

High

1244756

SYCE2
Synaptonemal complex central element protein 2

2

1

High-throughput

0.553

High

1292722

F90A1
Protein FAM90A1

2

1

High-throughput

0.553

High

1093143

STK4
Serine/threonine-protein kinase 4

1

8

Small-scale

0.552

High

1097700

STK3
Serine/threonine-protein kinase 3

1

7

Small-scale

0.552

High

1292731

TRI63
E3 ubiquitin-protein ligase TRIM63

1

18

High-throughput

0.541

High

1292743

TRI54
Tripartite motif-containing protein 54

1

18

High-throughput

0.541

High

1292744

TRI55
Tripartite motif-containing protein 55

1

18

High-throughput

0.541

High

167307

KLF11
Krueppel-like factor 11

1

20

High-throughput

0.515

High

246018

KIF1B
Kinesin-like protein KIF1B

1

13

High-throughput

0.515

High

374723

RASH
GTPase HRas

1

5

High-throughput

0.515

High

385919

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

17

High-throughput

0.515

High

390087

ALBU
Albumin

1

2

High-throughput

0.515

High

442388

GELS
Gelsolin

1

1

High-throughput

0.515

High

570485

GFAP
Glial fibrillary acidic protein

1

9

High-throughput

0.515

High

713113

NOS3
Nitric oxide synthase 3

1

2

High-throughput

0.515

High

767252

MERL
Merlin

1

5

High-throughput

0.515

High

856780

BAG6
Large proline-rich protein BAG6

1

12

High-throughput

0.515

High

904895

MECP2
Methyl-CpG-binding protein 2

1

3

High-throughput

0.515

High

927392

ATX1
Ataxin-1

1

1

High-throughput

0.515

High

937050

CASP6
Caspase-6

1

5

High-throughput

0.515

High

981568

RAN
GTP-binding nuclear protein Ran

1

4

High-throughput

0.515

High

1096083

TADBP
TAR DNA-binding protein 43

1

6

High-throughput

0.515

High

1199329

GLE1
mRNA export factor GLE1

1

5

High-throughput

0.515

High

1240374

Q6P088
ZNF483 protein

1

9

High-throughput

0.515

High

1279604

SPRE1
Sprouty-related, EVH1 domain-containing protein 1

1

6

High-throughput

0.515

High

1287236

Q86TH3
Dishevelled, dsh homolog 1

1

2

High-throughput

0.515

High

1292754

SHLB1
Endophilin-B1

1

3

High-throughput

0.515

High

422483

A4
Amyloid-beta precursor protein

1

3

High-throughput

0.501

High

906694

UB2D1
Ubiquitin-conjugating enzyme E2 D1

1

20

Small-scale

0.501

High

909339

UB2E1
Ubiquitin-conjugating enzyme E2 E1

1

20

Small-scale

0.501

High

957778

UBE2N
Ubiquitin-conjugating enzyme E2 N

1

20

Small-scale

0.501

High

970727

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

20

Small-scale

0.501

High

469862

ADH4
All-trans-retinol dehydrogenase [NAD(+)] ADH4

1

0

High-throughput

0.493

High

479606

DOPO
Dopamine beta-hydroxylase

1

0

High-throughput

0.493

High

702473

CLAT
Choline O-acetyltransferase

1

0

High-throughput

0.493

High

1292733

DDT4L
DNA damage-inducible transcript 4-like protein

1

0

High-throughput

0.493

High

1292725

SNX31
Sorting nexin-31

1

2

High-throughput

0.489

High

159371

DVL1
Segment polarity protein dishevelled homolog DVL-1

1

3

High-throughput

0.481

High

1292727

ZN483
Zinc finger protein 483

1

10

High-throughput

0.481

High

126318

TLR4
Toll-like receptor 4

1

6

Small-scale

0.479

High

191223

TLR3
Toll-like receptor 3

1

3

Small-scale

0.479

High

302573

RNF8
E3 ubiquitin-protein ligase RNF8

1

18

Small-scale

0.479

High

347789

BAG3
BAG family molecular chaperone regulator 3

1

2

High-throughput

0.479

High

478911

PO2F2
POU domain, class 2, transcription factor 2

1

2

Small-scale

0.479

High

604068

CXA1
Gap junction alpha-1 protein

1

4

Small-scale

0.479

High

714238

PML
Protein PML

1

20

Small-scale

0.479

High

788091

ODO2
Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial

1

1

Small-scale

0.479

High

1051939

KPCD
Protein kinase C delta type

1

7

Small-scale

0.479

High

1100081

TIF1B
Transcription intermediary factor 1-beta

1

20

Small-scale

0.479

High

1123964

DYHC1
Cytoplasmic dynein 1 heavy chain 1

1

1

Small-scale

0.479

High

1292729

HS105
Heat shock protein 105 kDa

1

7

Small-scale

0.479

High

1292748

TLR9
Toll-like receptor 9

1

3

Small-scale

0.479

High

46368

A0A1U9X8X8
Corneodesmosin

1

1

High-throughput

0.470

High

109450

G5E9A7
DM1 locus, WD repeat containing

1

6

High-throughput

0.470

High

369694

A2MG
Alpha-2-macroglobulin

1

2

High-throughput

0.470

High

562184

LAMP2
Lysosome-associated membrane glycoprotein 2

1

2

High-throughput

0.470

High

650272

FGFR3
Fibroblast growth factor receptor 3

1

4

High-throughput

0.470

High

1169438

Q1RN33
Melanoma antigen A 4

1

9

High-throughput

0.470

High

1292755

Q9Y649
GW128

1

1

High-throughput

0.470

High

69389

WASH1
WASH complex subunit 1

1

0

High-throughput

0.460

High

1292728

NU133
Nuclear pore complex protein Nup133

1

0

Small-scale

0.458

High

1292730

NU205
Nuclear pore complex protein Nup205

1

0

Small-scale

0.458

High

3385

A0A0S2Z4Q4
Hepatocyte growth factor-regulated tyrosine kinase substrate

1

8

High-throughput

0.457

High

1149515

CDSN
Corneodesmosin

1

1

High-throughput

0.439

High

873917

INAR2
Interferon alpha/beta receptor 2

1

1

Small-scale

0.437

High

431404

AT5G1
ATP synthase F(0) complex subunit C1, mitochondrial

5

0

High-throughput

0.374

High

1244498

IYD1
Iodotyrosine deiodinase 1

2

0

High-throughput

0.341

High

1292723

RBFA
Putative ribosome-binding factor A, mitochondrial

2

0

High-throughput

0.328

High

1292726

BL1S5
Biogenesis of lysosome-related organelles complex 1 subunit 5

2

0

High-throughput

0.328

High

1186087

MAJIN
Membrane-anchored junction protein

2

0

High-throughput

0.316

High

1292737

SMIP2
Protein SPMIP2

2

0

High-throughput

0.316

High

1292738

LYSM1
LysM and putative peptidoglycan-binding domain-containing protein 1

2

0

High-throughput

0.316

High

1292724

SYNE4
Nesprin-4

1

0

High-throughput

0.299

High

622206

NDUV2
NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial

1

0

High-throughput

0.268

Low

719973

HMOX2
Heme oxygenase 2

1

0

High-throughput

0.268

Low

1292721

Q86WV8
TSC complex subunit 1

1

0

High-throughput

0.268

Low

1292741

NUP58
Nucleoporin p58/p45

1

0

High-throughput

0.268

Low


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Last updated: 11Aug2025