HitPredict

Interactor 1: SH319 (Q5HYK7)
SH3 domain-containing protein 19 (ADAM-binding protein Eve-1) (EEN-binding protein) (EBP)
Gene: SH3D19

Interactor 2: ZO2 (Q9UDY2)
Tight junction protein ZO-2 (Tight junction protein 2) (Zona occludens protein 2) (Zonula occludens protein 2)
Gene: TJP2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	34079125
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Guanylate_kin~SH3_1, SH3_1~SH3_2, Guanylate_kin~SH3_2, PDZ~SH3_2, SH3_2~SH3_2, SH3_2~SH3_9
Common GO terms	GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 790 Hs			1 1190
+	Hs
		209185 NCK2_HUMAN (414-652): 5.41e-28: 118: 20.36		ZO2_HUMAN (1-1190): 0: 838: 100.00
+	Hs
		1354510 CD2AP_HUMAN (300-607): 3.02e-17: 88.2: 10.87		ZO2_HUMAN (1-1190): 0: 838: 100.00
+	Hs
		1167833 DNMBP_HUMAN (492-785): 3.4e-16: 85.6: 17.22		ZO2_HUMAN (1-1190): 0: 838: 100.00
+	Hs
		1285211 SH3K1_HUMAN (477-670): 2.62e-10: 65.9: 14.72		ZO2_HUMAN (1-1190): 0: 838: 100.00
+	Hs
		1314994 SRBS1_HUMAN (672-788): 2.98e-09: 62.8: 33.07		ZO2_HUMAN (1-1190): 0: 838: 100.00
+	Hs
		990858 SH319_HUMAN (1-790): 3.57e-99: 327: 100.00		ZO1_HUMAN (19-1187): 5.94e-133: 447: 36.80
+	Hs
		990871 DNMBP_HUMAN (492-785): 3.4e-16: 85.6: 17.22		ZO1_HUMAN (19-1187): 5.94e-133: 447: 36.80
+	Mm
		1113245 SRBS2_MOUSE (634-788): 1.16e-31: 135: 29.45		DLG4_MOUSE (3-423): 3.16e-52: 198: 18.89
+	Hs
		924466 GRB2_HUMAN (498-718): 1.8e-24: 104: 20.27		DLG4_HUMAN (3-423): 2.31e-52: 199: 18.89
+	Mm
		1141133 GRB2_MOUSE (498-718): 2.72e-24: 103: 20.27		DLG4_MOUSE (3-423): 3.16e-52: 198: 18.89
+	Mm
		223014 NCK2_MOUSE (346-572): 9.48e-15: 79: 13.25		DLG4_MOUSE (3-423): 3.16e-52: 198: 18.89
+	Mm
		1143451 SH3K1_MOUSE (309-686): 3.68e-13: 75.1: 11.84		DLG4_MOUSE (3-423): 3.16e-52: 198: 18.89
+	Mm
		1143326 SRBS1_MOUSE (621-790): 2.33e-12: 72.9: 16.94		DLG4_MOUSE (3-423): 3.16e-52: 198: 18.89
+	Mm
		1143413 SH3R3_MOUSE (212-550): 2.44e-12: 72.6: 18.28		DLG4_MOUSE (3-423): 3.16e-52: 198: 18.89
+	Hs
		1232491 SH3K1_HUMAN (477-670): 2.62e-10: 65.9: 14.72		PALS1_HUMAN (455-886): 1.77e-39: 159: 19.67
+	Dm
		993206 GRAP_DROME (498-720): 2.27e-21: 95.2: 22.22		Q9VHK4_DROME (24-347): 4.82e-23: 108: 21.17
+	Hs
		557746 NCK1_HUMAN (414-659): 8.08e-29: 120: 19.93		DLG5_HUMAN (25-522): 2.43e-14: 80.4: 11.77
+	Hs
		235554 VINEX_HUMAN (621-788): 1.29e-13: 76.7: 18.82		DLG5_HUMAN (25-522): 2.43e-14: 80.4: 11.77