HitPredict

Interactor 1: EXOS6 (Q5RKV6)
Exosome complex component MTR3 (Exosome component 6) (mRNA transport regulator 3 homolog) (hMtr3) (p11)
Gene: EXOSC6

Interactor 2: DI3L1 (Q8TF46)
DIS3-like exonuclease 1 (EC 3.1.13.1)
Gene: DIS3L

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.74	1.00	0.861

Property	Details
Experiments	24981860, 26496610, 20531386
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation, anti bait coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	OB_Dis3~RNase_PH, RNB~RNase_PH
Common GO terms	GO:0000177 - cytoplasmic exosome (RNase complex) GO:0003723 - RNA binding GO:0005829 - cytosol GO:0006396 - RNA processing GO:0006401 - RNA catabolic process and 1 others more... GO:0016075 - rRNA catabolic process
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 272 Hs			1 1054
+	Hs
		1257153 EXOS4_HUMAN (20-267): 1.16e-77: 237: 26.51		DI3L1_HUMAN (1-1054): 0: 1322: 100.00
+	Hs
		1257149 EXOS8_HUMAN (16-265): 1.31e-63: 202: 16.19		DI3L1_HUMAN (1-1054): 0: 1322: 100.00
+	Hs
		1063744 EXOS7_HUMAN (11-271): 3.95e-56: 183: 17.07		DI3L1_HUMAN (1-1054): 0: 1322: 100.00
+	Hs
		986702 EXOS9_HUMAN (9-271): 3.87e-49: 169: 13.22		DI3L1_HUMAN (1-1054): 0: 1322: 100.00
+	Hs
		1257154 EXOS5_HUMAN (12-266): 2.68e-49: 164: 25.29		DI3L1_HUMAN (1-1054): 0: 1322: 100.00
+	Hs
		1342631 EXOS4_HUMAN (20-267): 1.16e-77: 237: 26.51		RRP44_HUMAN (5-991): 0: 1027: 33.76
+	Hs
		1284999 EXOS8_HUMAN (16-265): 1.31e-63: 202: 16.19		RRP44_HUMAN (5-991): 0: 1027: 33.76
+	Hs
		1063785 EXOS7_HUMAN (11-271): 3.95e-56: 183: 17.07		RRP44_HUMAN (5-991): 0: 1027: 33.76
+	Hs
		986739 EXOS9_HUMAN (9-271): 3.87e-49: 169: 13.22		RRP44_HUMAN (5-991): 0: 1027: 33.76
+	Hs
		1343596 EXOS5_HUMAN (12-266): 2.68e-49: 164: 25.29		RRP44_HUMAN (5-991): 0: 1027: 33.76
+	At
		96521 RRP41_ARATH (20-267): 2.85e-78: 238: 27.42		F4INI6_ARATH (1-972): 0: 934: 31.24
+	Dm
		1362696 Q9VK19_DROME (18-270): 1.93e-72: 223: 29.53		Q9VC93_DROME (7-988): 0: 943: 31.52
+	Sp
		194782 RRP41_SCHPO (20-269): 9.37e-67: 209: 25.10		DIS3_SCHPO (5-972): 0: 941: 32.54
+	Sp
		252320 RRP45_SCHPO (5-267): 1.82e-56: 184: 12.63		DIS3_SCHPO (5-972): 0: 941: 32.54
+	Dm
		1250326 Q8T4A9_DROME (2-259): 3.86e-51: 174: 13.54		Q9VC93_DROME (7-988): 0: 943: 31.52
+	Dm
		1362694 Q9VGZ2_DROME (34-271): 7.39e-51: 168: 20.17		Q9VC93_DROME (7-988): 0: 943: 31.52
+	Sp
		740398 MTR3_SCHPO (3-251): 2.14e-49: 165: 25.78		DIS3_SCHPO (5-972): 0: 941: 32.54
+	Dm
		1362699 Q9VW53_DROME (8-206): 3.53e-44: 153: 27.67		Q9VC93_DROME (7-988): 0: 943: 31.52
+	Sc
		809596 RRP41_YEAST (17-271): 5.42e-60: 192: 21.32		RRP44_YEAST (2-971): 0: 893: 31.47
+	Sc
		860819 RRP46_YEAST (39-266): 4.01e-43: 148: 20.50		RRP44_YEAST (2-971): 0: 893: 31.47