HitPredict

Interactor 1: AP2A1 (O95782)
AP-2 complex subunit alpha-1 (100 kDa coated vesicle protein A) (Adaptor protein complex AP-2 subunit alpha-1) (Adaptor-related protein complex 2 subunit alpha-1) (Alpha-adaptin A) (Alpha1-adaptin) (Clathrin assembly protein complex 2 alpha-A large chain) (Plasma membrane adaptor HA2/AP2 adaptin alpha A subunit)
Gene: AP2A1

Interactor 2: DAB2 (P98082)
Disabled homolog 2 (Adaptor molecule disabled-2) (Differentially expressed in ovarian carcinoma 2) (DOC-2) (Differentially-expressed protein 2)
Gene: DAB2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	22323290
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0035615 - clathrin adaptor activity GO:0050750 - low-density lipoprotein particle receptor binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 977 Hs			1 770
+	Hs
		302137 AP2A2_HUMAN (1-977): 0: 832: 76.97		DAB2_HUMAN (1-770): 3.91e-90: 301: 100.00
+	Hs
		321513 AP2A1_HUMAN (1-977): 0: 904: 100.00		NUMB_HUMAN (22-635): 7.43e-47: 179: 14.20
+	Hs
		302120 AP2A2_HUMAN (1-977): 0: 832: 76.97		NUMB_HUMAN (22-635): 7.43e-47: 179: 14.20
+	Mm
		567529 AP2A2_MOUSE (1-977): 0: 841: 79.29		ANS1B_MOUSE (12-230): 5.35e-41: 164: 18.67
+	Hs
		203194 AP2A1_HUMAN (1-977): 0: 904: 100.00		SYNJ1_HUMAN (196-735): 1.47e-19: 96.5: 13.64
+	Rn
		1109842 Q66HM2_RAT (1-977): 0: 845: 79.39		Q3MUI1_RAT (22-637): 3.06e-36: 146: 13.27
+	Rn
		577194 AP2A2_RAT (1-977): 0: 841: 79.18		Q3MUI1_RAT (22-637): 3.06e-36: 146: 13.27
+	Hs
		925851 AP2B1_HUMAN (34-972): 0: 676: 17.11		DAB2_HUMAN (1-770): 3.91e-90: 301: 100.00
+	Dm
		561275 AP2A_DROME (3-977): 0: 784: 66.09		NUMB_DROME (24-530): 3.9e-41: 160: 12.25
+	Ce
		60774 Q22601_CAEEL (1-977): 0: 768: 60.49		A5JYR4_CAEEL (5-470): 5.67e-37: 147: 22.06
+	Ce
		283751 Q22601_CAEEL (1-977): 0: 768: 60.49		CED6_CAEEL (5-428): 1.43e-35: 143: 16.47
+	Hs
		925893 AP2B1_HUMAN (34-972): 0: 676: 17.11		ARH_HUMAN (13-293): 3.15e-56: 197: 13.54
+	Hs
		833572 AP2B1_HUMAN (34-972): 0: 676: 17.11		NUMB_HUMAN (22-635): 7.43e-47: 179: 14.20
+	Hs
		926067 AP2B1_HUMAN (34-972): 0: 676: 17.11		NUMBL_HUMAN (18-585): 6.55e-41: 161: 13.54
+	Hs
		925962 AP2B1_HUMAN (34-972): 0: 676: 17.11		ANS1A_HUMAN (1-227): 5e-36: 148: 19.05
+	Rn
		923852 AP2B1_RAT (34-972): 0: 676: 17.11		Q3MUI1_RAT (22-637): 3.06e-36: 146: 13.27
+	Hs
		253551 AP2B1_HUMAN (34-972): 0: 676: 17.11		CAPON_HUMAN (19-299): 8.52e-35: 141: 13.91
+	Hs
		203219 AP2B1_HUMAN (34-972): 0: 676: 17.11		SYNJ1_HUMAN (196-735): 1.47e-19: 96.5: 13.64
+	Hs
		203223 AP1B1_HUMAN (34-972): 0: 668: 18.15		SYNJ1_HUMAN (196-735): 1.47e-19: 96.5: 13.64
+	Hs
		926047 AP2B1_HUMAN (34-972): 0: 676: 17.11		MAGL2_HUMAN (165-765): 4.64e-12: 71.8: 8.27