HitPredict

Interactor 1: LRRK2 (Q5S007)
Leucine-rich repeat serine/threonine-protein kinase 2 (EC 2.7.11.1) (EC 3.6.5.-) (Dardarin)
Gene: LRRK2

Interactor 2: Q5U0I6 (Q5U0I6)
Ras-related protein Rab-1A
Gene: RAB1A

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	1.00	0.575

Property	Details
Experiments	unassigned1853
Identification Methods	anti tag coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	Pkinase~Ras, Ras~Roc
Common GO terms	GO:0003924 - GTPase activity GO:0005525 - GTP binding GO:0005794 - Golgi apparatus GO:0005886 - plasma membrane
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 2527 Hs			1 205
+	Hs
		918884 LRRK2_HUMAN (1-2527): 0: 3008: 99.72		RAB1A_HUMAN (1-205): 4.45e-92: 269: 100.00
+	Hs
		1119533 LRRK2_HUMAN (1-2527): 0: 3008: 99.72		Q504R6_HUMAN (2-203): 6.65e-86: 255: 50.50
+	Hs
		1130572 LRRK2_HUMAN (1-2527): 0: 3008: 99.72		RAB1B_HUMAN (4-205): 5.68e-86: 254: 92.08
+	Hs
		72911 LRRK2_HUMAN (1-2527): 0: 3008: 99.72		B4DMN1_HUMAN (1-205): 5.1e-84: 251: 44.60
+	Hs
		914117 LRRK2_HUMAN (1-2527): 0: 3008: 99.72		RB11A_HUMAN (1-205): 3.52e-83: 247: 44.60
+	Hs
		1079923 LRRK2_HUMAN (1-2527): 0: 3008: 99.72		RB11B_HUMAN (1-205): 1.3e-81: 243: 44.19
+	Hs
		894745 LRRK2_HUMAN (1-2527): 0: 3008: 99.72		RAB8A_HUMAN (4-203): 3.82e-81: 242: 54.00
+	Hs
		896632 LRRK2_HUMAN (1-2527): 0: 3008: 99.72		RAB14_HUMAN (1-205): 3.15e-81: 242: 41.86
+	At
		955322 BRL2_ARATH (1470-1771): 1.68e-09: 65.8: 10.33		RAB1C_ARATH (7-205): 3.76e-80: 239: 45.46