HitPredict

Interactor 1: LRRK2 (Q5S007)
Leucine-rich repeat serine/threonine-protein kinase 2 (EC 2.7.11.1) (EC 3.6.5.-) (Dardarin)
Gene: LRRK2

Interactor 2: MIRO1 (Q8IXI2)
Mitochondrial Rho GTPase 1 (MIRO-1) (hMiro-1) (EC 3.6.5.-) (Rac-GTP-binding protein-like protein) (Ras homolog gene family member T1)
Gene: RHOT1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	1.00	0.575

Property	Details
Experiments	unassigned1853
Identification Methods	anti tag coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	Pkinase~Ras, Ras~Roc
Common GO terms	GO:0003924 - GTPase activity GO:0005525 - GTP binding GO:0005739 - mitochondrion GO:0005741 - mitochondrial outer membrane GO:0007005 - mitochondrion organization and 1 others more... GO:0007165 - signal transduction
Homologous interactions	14

Homologous interactions

Color coding for hit scores

	1 2527 Hs			1 618
+	Hs
		1130165 LRRK2_HUMAN (1-2527): 0: 3008: 99.72		Q5U0I6_HUMAN (5-190): 5.36e-74: 237: 20.21
+	Hs
		918884 LRRK2_HUMAN (1-2527): 0: 3008: 99.72		RAB1A_HUMAN (5-190): 5.36e-74: 237: 20.21
+	Hs
		925337 LRRK2_HUMAN (1-2527): 0: 3008: 99.72		RAC1_HUMAN (3-181): 7.62e-73: 234: 23.83
+	Hs
		1070230 LRRK2_HUMAN (1-2527): 0: 3008: 99.72		RAB35_HUMAN (5-168): 1.96e-72: 233: 25.90
+	Hs
		72911 LRRK2_HUMAN (1-2527): 0: 3008: 99.72		B4DMN1_HUMAN (5-201): 2.67e-71: 232: 19.60
+	Hs
		1119533 LRRK2_HUMAN (1-2527): 0: 3008: 99.72		Q504R6_HUMAN (5-191): 3.81e-71: 231: 19.59
+	Hs
		914117 LRRK2_HUMAN (1-2527): 0: 3008: 99.72		RB11A_HUMAN (5-201): 1.75e-71: 231: 19.60
+	Hs
		1130572 LRRK2_HUMAN (1-2527): 0: 3008: 99.72		RAB1B_HUMAN (5-172): 2.1e-71: 230: 21.77
+	Hs
		894745 LRRK2_HUMAN (1-2527): 0: 3008: 99.72		RAB8A_HUMAN (5-196): 2.97e-71: 230: 18.56
+	Hs
		59884 LRRK2_HUMAN (1-2527): 0: 3008: 99.72		A4D2P0_HUMAN (3-181): 5.72e-69: 224: 22.64
+	Hs
		125 LRRK2_HUMAN (1-2527): 0: 3008: 99.72		A0A024R324_HUMAN (6-186): 1.33e-65: 214: 23.59
+	Hs
		900557 LRRK2_HUMAN (1-2527): 0: 3008: 99.72		RHOA_HUMAN (6-186): 1.33e-65: 214: 23.59
+	Mm
		925792 LRRK2_MOUSE (1-2527): 0: 2865: 86.09		RAC1_MOUSE (3-181): 7.62e-73: 234: 23.83
+	Hs
		925212 M3K10_HUMAN (1864-2136): 2.39e-23: 110: 32.20		RAC1_HUMAN (3-181): 7.62e-73: 234: 23.83