HitPredict

Interactor 1: LRRK2 (Q5S007)
Leucine-rich repeat serine/threonine-protein kinase 2 (EC 2.7.11.1) (EC 3.6.5.-) (Dardarin)
Gene: LRRK2

Interactor 2: UN45A (Q9H3U1)
Protein unc-45 homolog A (Unc-45A) (GCUNC-45) (Smooth muscle cell-associated protein 1) (SMAP-1)
Gene: UNC45A

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	0.60	0.445

Property	Details
Experiments	unassigned1853
Identification Methods	anti tag coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005794 - Golgi apparatus GO:0005829 - cytosol
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 2527 Hs			1 944
+	Hs
		1130595 LRRK2_HUMAN (1-2527): 0: 3008: 99.72		RPAP3_HUMAN (15-343): 5.32e-41: 163: 17.06
+	Hs
		1130729 LRRK2_HUMAN (1-2527): 0: 3008: 99.72		CHIP_HUMAN (8-159): 1.54e-35: 139: 29.30
+	Hs
		174950 LRRK2_HUMAN (1-2527): 0: 3008: 99.72		OGT1_HUMAN (3-192): 2.53e-24: 112: 12.63
+	Hs
		684799 LRRK2_HUMAN (1-2527): 0: 3008: 99.72		STIP1_HUMAN (4-228): 9.18e-17: 86.8: 15.32
+	Hs
		66551 LRRK2_HUMAN (1-2527): 0: 3008: 99.72		A8K690_HUMAN (4-228): 2.43e-15: 82.2: 15.32
+	Hs
		297066 LRRK2_HUMAN (1-2527): 0: 3008: 99.72		TOM70_HUMAN (12-220): 4.6e-09: 62.2: 13.08
+	Mm
		1130140 LRRK2_MOUSE (1-2527): 0: 2865: 86.09		CHIP_MOUSE (17-159): 3.41e-35: 138: 29.05
+	Hs
		684476 CSK_HUMAN (1722-2140): 2.25e-102: 339: 20.74		STIP1_HUMAN (4-228): 9.18e-17: 86.8: 15.32
+	Dm
		1363778 Q9VDJ9_DROME (1810-2154): 3.35e-55: 216: 26.46		Q9VH81_DROME (6-180): 1.39e-38: 153: 22.29
+	Dm
		1364726 SUR8_DROME (972-1338): 5.78e-52: 197: 23.12		Q9VH81_DROME (6-180): 1.39e-38: 153: 22.29
+	Hs
		175307 SHOC2_HUMAN (944-1353): 1.23e-60: 222: 22.27		OGT1_HUMAN (3-192): 2.53e-24: 112: 12.63
+	Hs
		858630 LRRK1_HUMAN (771-1194): 2.3e-35: 151: 16.38		PPP5_HUMAN (10-180): 3.77e-39: 154: 23.98
+	Hs
		1332525 MFHA1_HUMAN (838-1119): 1.5e-30: 134: 16.95		RPAP3_HUMAN (15-343): 5.32e-41: 163: 17.06
+	Hs
		1105500 LRRK1_HUMAN (771-1194): 2.3e-35: 151: 16.38		CHIP_HUMAN (8-159): 1.54e-35: 139: 29.30
+	Hs
		1357487 MFHA1_HUMAN (838-1119): 1.5e-30: 134: 16.95		CHIP_HUMAN (8-159): 1.54e-35: 139: 29.30
+	Mm
		1141210 M3K7_MOUSE (1869-2132): 1.06e-22: 107: 28.83		PPP5_MOUSE (10-180): 2.35e-39: 155: 23.98
+	Hs
		201277 M3K7_HUMAN (1869-2132): 8.36e-23: 107: 28.83		PPP5_HUMAN (10-180): 3.77e-39: 154: 23.98
+	Hs
		945783 M3K9_HUMAN (1874-2136): 3.07e-24: 114: 32.38		CHIP_HUMAN (8-159): 1.54e-35: 139: 29.30
+	Hs
		201465 M3K7_HUMAN (1869-2132): 8.36e-23: 107: 28.83		CHIP_HUMAN (8-159): 1.54e-35: 139: 29.30