HitPredict

Interactor 1: NHRF3 (Q5T2W1)
Na(+)/H(+) exchange regulatory cofactor NHE-RF3 (NHERF-3) (CFTR-associated protein of 70 kDa) (Na(+)/H(+) exchanger regulatory factor 3) (Na/Pi cotransporter C-terminal-associated protein 1) (NaPi-Cap1) (PDZ domain-containing protein 1) (Sodium-hydrogen exchanger regulatory factor 3)
Gene: PDZK1

Interactor 2: SHKB1 (Q8TBC3)
SH3KBP1-binding protein 1 (SETA-binding protein 1)
Gene: SHKBP1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.50	0.558

Property	Details
Experiments	28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 519 Hs			1 707
+	Hs
		1132930 NHRF3_HUMAN (1-519): 1.87e-114: 350: 100.00		KCTD3_HUMAN (3-657): 0: 992: 63.58
+	Hs
		153935 NHRF1_HUMAN (5-134): 6.99e-24: 104: 31.54		SHKB1_HUMAN (1-707): 0: 1175: 100.00
+	Hs
		1020242 PTN13_HUMAN (72-497): 1.88e-29: 125: 12.84		KCTD3_HUMAN (3-657): 0: 992: 63.58
+	Hs
		1132926 NHRF3_HUMAN (1-519): 1.87e-114: 350: 100.00		KCTD5_HUMAN (4-127): 2.47e-37: 141: 35.43
+	Hs
		1057225 NHRF3_HUMAN (1-519): 1.87e-114: 350: 100.00		KCTD2_HUMAN (13-124): 2.17e-36: 139: 41.53
+	Hs
		1132909 NHRF3_HUMAN (1-519): 1.87e-114: 350: 100.00		KCD17_HUMAN (19-118): 8.5e-35: 136: 45.10
+	Mm
		558878 DLG4_MOUSE (3-344): 3.77e-36: 144: 16.96		KCNA3_MOUSE (3-228): 1.37e-44: 169: 15.45
+	Hs
		602901 DLG4_HUMAN (3-344): 2.27e-36: 145: 17.22		KCNA3_HUMAN (3-228): 3.36e-43: 166: 15.04
+	Hs
		558713 DLG4_HUMAN (3-344): 2.27e-36: 145: 17.22		KCNA2_HUMAN (1-231): 1.12e-42: 163: 13.82
+	Mm
		927733 DLG4_MOUSE (3-344): 3.77e-36: 144: 16.96		KCNA2_MOUSE (1-231): 1.19e-42: 163: 13.82
+	Hs
		942389 DLG4_HUMAN (3-344): 2.27e-36: 145: 17.22		KCND2_HUMAN (1-231): 1.9e-41: 162: 19.75
+	Hs
		942333 DLG4_HUMAN (3-344): 2.27e-36: 145: 17.22		KCNA1_HUMAN (2-231): 9.51e-42: 161: 15.10
+	Mm
		558703 DLG4_MOUSE (3-344): 3.77e-36: 144: 16.96		KCNA1_MOUSE (2-231): 1.73e-41: 160: 15.10
+	Rn
		548174 DLG4_RAT (3-344): 2.03e-36: 145: 17.22		KCNA4_RAT (13-231): 1.83e-39: 156: 16.46
+	Hs
		608221 DLG4_HUMAN (3-344): 2.27e-36: 145: 17.22		KCNA4_HUMAN (13-231): 1.8e-39: 156: 16.46
+	Mm
		1142574 DLG4_MOUSE (3-344): 3.77e-36: 144: 16.96		KCNA4_MOUSE (13-231): 1.82e-39: 156: 16.46
+	Hs
		608244 DLG3_HUMAN (3-359): 3.36e-32: 133: 17.27		KCNA4_HUMAN (13-231): 1.8e-39: 156: 16.46
+	Rn
		548175 DLG3_RAT (3-359): 6.78e-32: 132: 17.27		KCNA4_RAT (13-231): 1.83e-39: 156: 16.46
+	Hs
		1057230 DLG3_HUMAN (3-359): 3.36e-32: 133: 17.27		KCTD2_HUMAN (13-124): 2.17e-36: 139: 41.53
+	Hs
		153919 NHRF1_HUMAN (5-134): 6.99e-24: 104: 31.54		KCTD2_HUMAN (13-124): 2.17e-36: 139: 41.53