HitPredict

Interactor 1: Q5TA56 (Q5TA56)
Argonaute RISC catalytic component 3 (Eukaryotic translation initiation factor 2C, 3, isoform CRA_a)
Gene: AGO3

Interactor 2: Q6PK50 (Q6PK50)
Heat shock protein HSP 90-beta
Gene: HSP90AB1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.50	0.437

Property	Details
Experiments	25036637
Identification Methods	luminescence based mammalian interactome mapping
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 229 Hs			1 351
+	Hs
		431946 Q5TA56_HUMAN (1-229): 3.72e-126: 357: 100.00		HS90A_HUMAN (1-350): 1.31e-173: 501: 84.92
+	Hs
		438537 AGO3_HUMAN (1-219): 5.74e-111: 339: 100.00		HS90B_HUMAN (1-345): 1.2e-175: 506: 100.00
+	Hs
		432271 AGO3_HUMAN (1-219): 5.74e-111: 339: 100.00		HS90A_HUMAN (1-350): 1.31e-173: 501: 84.92
+	Mm
		1174807 AGO2_MOUSE (4-219): 7.33e-101: 313: 62.04		Q71LX8_MOUSE (1-345): 1.63e-176: 509: 99.71
+	Hs
		438614 AGO2_HUMAN (14-219): 1.71e-100: 311: 64.56		HS90B_HUMAN (1-345): 1.2e-175: 506: 100.00
+	Hs
		438615 AGO1_HUMAN (9-219): 1.03e-99: 310: 69.19		HS90B_HUMAN (1-345): 1.2e-175: 506: 100.00
+	Mm
		432448 AGO2_MOUSE (4-219): 7.33e-101: 313: 62.04		HS90A_MOUSE (1-350): 2.76e-173: 501: 84.12
+	Hs
		432355 AGO2_HUMAN (14-219): 1.71e-100: 311: 64.56		HS90A_HUMAN (1-350): 1.31e-173: 501: 84.92
+	Hs
		432356 AGO1_HUMAN (9-219): 1.03e-99: 310: 69.19		HS90A_HUMAN (1-350): 1.31e-173: 501: 84.92
+	Hs
		438545 AGO4_HUMAN (3-219): 3.44e-96: 300: 66.36		HS90B_HUMAN (1-345): 1.2e-175: 506: 100.00
+	Hs
		432278 AGO4_HUMAN (3-219): 3.44e-96: 300: 66.36		HS90A_HUMAN (1-350): 1.31e-173: 501: 84.92
+	Dm
		365460 Q32KD4_DROME (3-219): 4.18e-94: 297: 56.16		HSP83_DROME (8-350): 1.73e-170: 493: 79.88
+	At
		138329 AGO1_ARATH (7-219): 2.11e-96: 304: 37.79		HS903_ARATH (10-349): 6.08e-158: 460: 67.16
+	Hs
		1123461 AGO3_HUMAN (1-219): 5.74e-111: 339: 100.00		H90B3_HUMAN (1-345): 2.38e-137: 404: 79.13
+	Hs
		1123440 AGO3_HUMAN (1-219): 5.74e-111: 339: 100.00		H90B4_HUMAN (25-328): 1.55e-133: 392: 83.22
+	Dm
		1103835 Q32KD4_DROME (3-219): 4.18e-94: 297: 56.16		Q9VAY2_DROME (4-350): 4e-139: 415: 43.63
+	Hs
		1123444 AGO2_HUMAN (14-219): 1.71e-100: 311: 64.56		H90B4_HUMAN (25-328): 1.55e-133: 392: 83.22
+	Hs
		1123445 AGO1_HUMAN (9-219): 1.03e-99: 310: 69.19		H90B4_HUMAN (25-328): 1.55e-133: 392: 83.22
+	Ce
		108540 G5EGR6_CAEEL (8-219): 7.79e-85: 273: 46.50		ENPL1_CAEEL (3-349): 5.02e-144: 427: 43.34
+	Hs
		1123442 AGO4_HUMAN (3-219): 3.44e-96: 300: 66.36		H90B4_HUMAN (25-328): 1.55e-133: 392: 83.22