HitPredict

Interactor 1: MRCKA (Q5VT25)
Serine/threonine-protein kinase MRCK alpha (EC 2.7.11.1) (CDC42-binding protein kinase alpha) (DMPK-like alpha) (Myotonic dystrophy kinase-related CDC42-binding kinase alpha) (MRCK alpha) (Myotonic dystrophy protein kinase-like alpha)
Gene: CDC42BPA

Interactor 2: PARD3 (Q8TEW0)
Partitioning defective 3 homolog (PAR-3) (PARD-3) (Atypical PKC isotype-specific-interacting protein) (ASIP) (CTCL tumor antigen se2-5) (PAR3-alpha)
Gene: PARD3

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	34079125
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0005856 - cytoskeleton GO:0005911 - cell-cell junction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1732 Hs			1 1356
+	Hs
		990961 MRCKB_HUMAN (1-1731): 0: 1417: 60.38		ZO1_HUMAN (271-586): 1.19e-11: 72: 14.06
+	Hs
		149091 CTRO_HUMAN (4-1044): 3.09e-128: 447: 24.43		PARD3_HUMAN (1-1356): 0: 709: 100.00
+	Hs
		148925 CTRO_HUMAN (4-1044): 3.09e-128: 447: 24.43		MAGI3_HUMAN (61-1272): 3.28e-32: 139: 10.65
+	Rn
		92840 CTRO_RAT (4-1025): 1.66e-127: 445: 23.89		DLG4_RAT (540-699): 1e-22: 107: 27.98
+	Hs
		149188 CTRO_HUMAN (4-1044): 3.09e-128: 447: 24.43		MAGI1_HUMAN (354-780): 1.36e-16: 88.1: 14.16
+	Hs
		149079 CTRO_HUMAN (4-1044): 3.09e-128: 447: 24.43		INADL_HUMAN (28-397): 1.09e-15: 85.1: 11.14
+	Mm
		823534 CTRO_MOUSE (4-1025): 1.07e-120: 424: 23.41		DLG4_MOUSE (540-699): 7.89e-23: 107: 27.98
+	Hs
		149084 CTRO_HUMAN (4-1044): 3.09e-128: 447: 24.43		LNX1_HUMAN (73-395): 1.66e-13: 77.4: 12.79
+	Hs
		148718 CTRO_HUMAN (4-1044): 3.09e-128: 447: 24.43		ZO1_HUMAN (271-586): 1.19e-11: 72: 14.06
+	Mm
		949403 TNIK_MOUSE (53-700): 2.14e-94: 337: 15.88		RIMS1_MOUSE (346-947): 3.91e-45: 181: 17.00
+	Hs
		148800 CTRO_HUMAN (4-1044): 3.09e-128: 447: 24.43		SCRIB_HUMAN (66-355): 5.59e-09: 63.1: 12.75
+	Mm
		949394 TNIK_MOUSE (53-700): 2.14e-94: 337: 15.88		DLG2_MOUSE (192-784): 2.75e-43: 173: 14.69
+	Mm
		949302 TNIK_MOUSE (53-700): 2.14e-94: 337: 15.88		DLG4_MOUSE (540-699): 7.89e-23: 107: 27.98
+	Mm
		949354 TNIK_MOUSE (53-700): 2.14e-94: 337: 15.88		DLG1_MOUSE (274-579): 3.13e-22: 106: 17.50
+	Mm
		949429 TNIK_MOUSE (53-700): 2.14e-94: 337: 15.88		MAGI2_MOUSE (130-412): 1.25e-15: 84.7: 11.81
+	Mm
		761850 TNIK_MOUSE (53-700): 2.14e-94: 337: 15.88		ZO1_MOUSE (271-1335): 5.5e-12: 73.1: 8.69
+	Hs
		1232910 LATS2_HUMAN (65-376): 3.53e-75: 275: 41.23		LNX2_HUMAN (50-361): 6.83e-21: 101: 11.35
+	Hs
		280078 LATS2_HUMAN (65-376): 3.53e-75: 275: 41.23		MPDZ_HUMAN (446-543): 1.36e-20: 101: 40.82
+	Hs
		1020225 LATS2_HUMAN (65-376): 3.53e-75: 275: 41.23		PTN13_HUMAN (39-368): 1.59e-16: 88.1: 12.50
+	Hs
		990944 LATS2_HUMAN (65-376): 3.53e-75: 275: 41.23		ZO1_HUMAN (271-586): 1.19e-11: 72: 14.06