Protein: BRK1
Protein BRICK1 (BRK1)

Gene: BRK1
Organism: Homo sapiens
Interactions: 195
UniProt ID: Q8WUW1

Gene Ontology (top 5):
GO:0001701 - in utero embryonic development
GO:0005829 - cytosol
GO:0005856 - cytoskeleton
GO:0007015 - actin filament organization
GO:0008064 - regulation of actin polymerization or depolymerization

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1357208

NDEL1
Nuclear distribution protein nudE-like 1

5

1

High-throughput

0.715

High

1357188

WASF1
Actin-binding protein WASF1

5

10

Small-scale

0.712

High

222162

NCK2
Cytoplasmic protein NCK2

4

1

High-throughput

0.691

High

284463

HSBP1
Heat shock factor-binding protein 1

4

1

High-throughput

0.689

High

1357219

ABI2
Abl interactor 2

4

4

Small-scale

0.687

High

1357233

NCKP1
Nck-associated protein 1

4

2

Small-scale

0.687

High

1357192

DTBP1
Dysbindin

4

0

High-throughput

0.675

High

1316683

ABI1
Abl interactor 1

3

4

High-throughput

0.662

High

1357231

WASF3
Actin-binding protein WASF3

3

10

High-throughput

0.662

High

1357241

WASF2
Actin-binding protein WASF2

3

10

High-throughput

0.662

High

1351911

RBCC1
RB1-inducible coiled-coil protein 1

3

1

High-throughput

0.650

High

1272185

CYFP1
Cytoplasmic FMR1-interacting protein 1

3

3

Small-scale

0.643

High

1357201

AKAP9
A-kinase anchor protein 9

2

2

High-throughput

0.621

High

1357232

BAIP2
BAR/IMD domain-containing adapter protein 2

2

0

High-throughput

0.602

High

594057

NCK1
SH2/SH3 adapter protein NCK1

2

1

High-throughput

0.601

High

749969

KINH
Kinesin-1 heavy chain

2

3

High-throughput

0.601

High

1095569

LIPA1
Liprin-alpha-1

2

2

High-throughput

0.601

High

1247747

NHS
Actin remodeling regulator NHS

2

2

High-throughput

0.601

High

1352121

ES8L1
Epidermal growth factor receptor kinase substrate 8-like protein 1

2

2

High-throughput

0.601

High

1357193

CYFP2
Cytoplasmic FMR1-interacting protein 2

2

3

High-throughput

0.601

High

1357217

BL1S4
Biogenesis of lysosome-related organelles complex 1 subunit 4

2

1

High-throughput

0.601

High

1357218

NDE1
Nuclear distribution protein nudE homolog 1

2

1

High-throughput

0.601

High

1217894

BRE1A
E3 ubiquitin-protein ligase BRE1A

3

2

High-throughput

0.599

High

988561

RAC1
Ras-related C3 botulinum toxin substrate 1

2

5

Small-scale

0.594

High

1357227

PKHH1
Pleckstrin homology domain-containing family H member 1

2

0

High-throughput

0.576

High

1357189

P55G
Phosphatidylinositol 3-kinase regulatory subunit gamma

2

0

High-throughput

0.551

High

1211400

NHSL1
NHS-like protein 1

2

2

High-throughput

0.549

High

1357197

SCLT1
Sodium channel and clathrin linker 1

2

0

High-throughput

0.547

High

271632

LIPA3
Liprin-alpha-3

1

2

High-throughput

0.536

High

276380

LIPA2
Liprin-alpha-2

1

2

High-throughput

0.536

High

340193

PCNT
Pericentrin

1

4

High-throughput

0.536

High

507292

UBB
Polyubiquitin-B [Cleaved into: Ubiquitin]

1

1

High-throughput

0.536

High

883925

CENPF
Centromere protein F

1

2

High-throughput

0.536

High

936243

NCKPL
Nck-associated protein 1-like

1

2

High-throughput

0.536

High

1087017

KIF5A
Kinesin heavy chain isoform 5A

1

3

High-throughput

0.536

High

1137888

TNIP1
TNFAIP3-interacting protein 1

1

1

High-throughput

0.536

High

1150936

TRIPB
Thyroid receptor-interacting protein 11

1

1

High-throughput

0.536

High

1295199

HOME1
Homer protein homolog 1

1

1

High-throughput

0.536

High

1310156

GCC2
GRIP and coiled-coil domain-containing protein 2

1

1

High-throughput

0.536

High

1357199

CEP89
Centrosomal protein of 89 kDa

1

1

High-throughput

0.536

High

1357205

UACA
Uveal autoantigen with coiled-coil domains and ankyrin repeats

1

1

High-throughput

0.536

High

1357209

KLC2
Kinesin light chain 2

1

1

High-throughput

0.536

High

242404

PRKN
E3 ubiquitin-protein ligase parkin

1

1

High-throughput

0.515

High

570523

GFAP
Glial fibrillary acidic protein

1

1

High-throughput

0.515

High

833324

PERI
Peripherin

1

1

High-throughput

0.515

High

1279662

SPRE1
Sprouty-related, EVH1 domain-containing protein 1

1

2

High-throughput

0.515

High

271553

ATG13
Autophagy-related protein 13

1

0

High-throughput

0.513

High

279193

ULK1
Serine/threonine-protein kinase ULK1

1

0

High-throughput

0.513

High

333378

SNAPN
SNARE-associated protein Snapin

1

0

High-throughput

0.513

High

459695

PROF1
Profilin-1

1

0

High-throughput

0.513

High

932345

ARSF
Arylsulfatase F

1

0

High-throughput

0.513

High

993265

ACTG
Actin, cytoplasmic 2

1

0

High-throughput

0.513

High

1008484

BL1S1
Biogenesis of lysosome-related organelles complex 1 subunit 1

1

0

High-throughput

0.513

High

1141822

EEA1
Early endosome antigen 1

1

0

High-throughput

0.513

High

1150522

DIXC1
Dixin

1

0

High-throughput

0.513

High

1196287

GRAP1
GRIP1-associated protein 1

1

0

High-throughput

0.513

High

1246489

BL1S2
Biogenesis of lysosome-related organelles complex 1 subunit 2

1

0

High-throughput

0.513

High

1308506

CNGA4
Cyclic nucleotide-gated channel alpha-4

1

0

High-throughput

0.513

High

1311204

RHG12
Rho GTPase-activating protein 12

1

0

High-throughput

0.513

High

1331332

AL14E
ARL14 effector protein

1

0

High-throughput

0.513

High

1357196

SPTCS
Spatacsin

1

0

High-throughput

0.513

High

1357203

ATGA1
Autophagy-related protein 101

1

0

High-throughput

0.513

High

1357206

CEP44
Centrosomal protein of 44 kDa

1

0

High-throughput

0.513

High

1357213

DISC1
Disrupted in schizophrenia 1 protein

1

0

High-throughput

0.513

High

1357214

MBIP1
MAP3K12-binding inhibitory protein 1

1

0

High-throughput

0.513

High

1357215

SYFB
Phenylalanine--tRNA ligase beta subunit

1

0

High-throughput

0.513

High

1357225

BL1S6
Biogenesis of lysosome-related organelles complex 1 subunit 6

1

0

High-throughput

0.513

High

1357230

TBD2B
TBC1 domain family member 2B

1

0

High-throughput

0.513

High

1357239

MD1L1
Mitotic spindle assembly checkpoint protein MAD1

1

0

High-throughput

0.513

High

143880

NDKM
Nucleoside diphosphate kinase, mitochondrial

1

0

High-throughput

0.493

High

162643

ANM5
Protein arginine N-methyltransferase 5

1

0

High-throughput

0.493

High

167336

KLF11
Krueppel-like factor 11

1

0

High-throughput

0.493

High

193800

PER1
Period circadian protein homolog 1

1

0

High-throughput

0.493

High

369713

A2MG
Alpha-2-macroglobulin

1

0

High-throughput

0.493

High

488522

UCHL1
Ubiquitin carboxyl-terminal hydrolase isozyme L1

1

0

High-throughput

0.493

High

688080

EF1G
Elongation factor 1-gamma

1

0

High-throughput

0.493

High

705487

GRN
Progranulin

1

0

High-throughput

0.493

High

791573

SYUA
Alpha-synuclein

1

0

High-throughput

0.493

High

821478

TCPZ
T-complex protein 1 subunit zeta

1

0

High-throughput

0.493

High

843803

HD
Huntingtin

1

0

High-throughput

0.493

High

856833

BAG6
Large proline-rich protein BAG6

1

0

High-throughput

0.493

High

896834

DYN2
Dynamin-2

1

0

High-throughput

0.493

High

904965

MECP2
Methyl-CpG-binding protein 2

1

0

High-throughput

0.493

High

957635

UBE2K
Ubiquitin-conjugating enzyme E2 K

1

0

High-throughput

0.493

High

1123734

DCTN1
Dynactin subunit 1

1

0

High-throughput

0.493

High

1272041

CD37L
Hsp90 co-chaperone Cdc37-like 1

1

0

High-throughput

0.493

High

1287272

DPP9
Dipeptidyl peptidase 9

1

0

High-throughput

0.493

High

1357194

OTUB1
Ubiquitin thioesterase OTUB1

1

0

High-throughput

0.493

High

1357200

ATX2
Ataxin-2

1

0

High-throughput

0.493

High

1357204

NUP58
Nucleoporin p58/p45

1

0

High-throughput

0.493

High

1357236

RNF11
RING finger protein 11

1

0

High-throughput

0.493

High

244177

KIF5C
Kinesin heavy chain isoform 5C

1

3

High-throughput

0.489

High

272717

BRE1B
E3 ubiquitin-protein ligase BRE1B

1

2

High-throughput

0.489

High

1200052

EIPR1
EARP and GARP complex-interacting protein 1

1

1

High-throughput

0.489

High

1357216

KLC4
Kinesin light chain 4

1

1

High-throughput

0.489

High

1278911

BRAP
BRCA1-associated protein

1

0

Small-scale

0.486

High

363622

EGFR
Epidermal growth factor receptor

1

3

High-throughput

0.479

High

374095

RASN
GTPase NRas

1

2

High-throughput

0.479

High

374805

RASH
GTPase HRas

1

2

High-throughput

0.479

High

375770

RASK
GTPase KRas

1

2

High-throughput

0.479

High

466383

RHOC
Rho-related GTP-binding protein RhoC

1

5

High-throughput

0.479

High

581195

RAC2
Ras-related C3 botulinum toxin substrate 2

1

5

High-throughput

0.479

High

710867

EPHB2
Ephrin type-B receptor 2

1

3

High-throughput

0.479

High

953585

RAC3
Ras-related C3 botulinum toxin substrate 3

1

5

High-throughput

0.479

High

955416

CDC42
Cell division control protein 42 homolog

1

5

High-throughput

0.479

High

962316

RHOA
Transforming protein RhoA

1

5

High-throughput

0.479

High

109474

G5E9A7
DM1 locus, WD repeat containing

1

1

High-throughput

0.470

High

246070

KIF1B
Kinesin-like protein KIF1B

1

3

High-throughput

0.470

High

164401

NRP1
Neuropilin-1

1

0

High-throughput

0.458

High

942776

BCAR1
Breast cancer anti-estrogen resistance protein 1

1

0

High-throughput

0.458

High

947236

NLRP6
NACHT, LRR and PYD domains-containing protein 6

1

0

High-throughput

0.458

High

1357224

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.458

High

1357222

PCD10
Protocadherin-10

1

4

Small-scale

0.457

High

896593

VASP
Vasodilator-stimulated phosphoprotein

1

2

High-throughput

0.445

High

1357221

ABI3
ABI gene family member 3

1

4

High-throughput

0.445

High

1357240

ROBO1
Roundabout homolog 1

1

1

Small-scale

0.445

High

931875

EPHA5
Ephrin type-A receptor 5

1

3

High-throughput

0.437

High

932107

EPHA4
Ephrin type-A receptor 4

1

3

High-throughput

0.437

High

1147392

EPHA7
Ephrin type-A receptor 7

1

3

High-throughput

0.437

High

530123

TAU
Microtubule-associated protein tau

1

0

High-throughput

0.426

High

1316265

PACE1
Protein-associating with the carboxyl-terminal domain of ezrin

1

0

High-throughput

0.426

High

1357195

AURKB
Aurora kinase B

1

0

High-throughput

0.426

High

1357198

SYGP1
Ras/Rap GTPase-activating protein SynGAP

1

0

High-throughput

0.426

High

167756

PCD17
Protocadherin-17

1

5

Small-scale

0.407

High

329402

PCDH8
Protocadherin-8

1

6

Small-scale

0.407

High

1007742

RAE1L
mRNA export factor RAE1

1

1

High-throughput

0.407

High

1205200

NHSL2
NHS-like protein 2

1

2

High-throughput

0.407

High

1249974

LRIG3
Leucine-rich repeats and immunoglobulin-like domains protein 3

1

1

Small-scale

0.407

High

1280677

Q7Z738
Protocadherin-12

1

6

Small-scale

0.407

High

1322274

NLGNX
Neuroligin-4, X-linked

1

1

Small-scale

0.407

High

1324498

NLGN1
Neuroligin-1

1

1

Small-scale

0.407

High

1346675

PCD19
Protocadherin-19

1

6

Small-scale

0.407

High

1357185

CSKI2
Caskin-2

1

1

High-throughput

0.407

High

1357212

PCD18
Protocadherin-18

1

6

Small-scale

0.407

High

1357229

PCDA6
Protocadherin alpha-6

1

1

Small-scale

0.407

High

1357235

WASC3
WASH complex subunit 3

3

0

High-throughput

0.345

High

1357238

MOFA1
MORF4 family-associated protein 1

3

0

High-throughput

0.344

High

286691

STX11
Syntaxin-11

2

0

High-throughput

0.328

High

1192200

AMZ1
Archaemetzincin-1

2

0

High-throughput

0.328

High

1357228

CBLC
E3 ubiquitin-protein ligase CBL-C

2

0

High-throughput

0.328

High

1139778

SETB1
Histone-lysine N-methyltransferase SETDB1

2

0

High-throughput

0.313

High

1331990

BANP
Protein BANP

2

0

High-throughput

0.313

High

1334154

POC1A
POC1 centriolar protein homolog A

2

0

High-throughput

0.313

High

1357211

CCSE2
Serine-rich coiled-coil domain-containing protein 2

2

0

High-throughput

0.313

High

1357220

NHSL3
NHS-like protein 3

2

0

High-throughput

0.313

High

60138

CCD78
Coiled-coil domain-containing protein 78

1

0

High-throughput

0.279

Low

505184

OST4
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 4

1

0

High-throughput

0.279

Low

789185

NUP62
Nuclear pore glycoprotein p62

1

0

High-throughput

0.279

Low

1192070

TIM50
Mitochondrial import inner membrane translocase subunit TIM50

1

0

High-throughput

0.279

Low

1194663

CCD40
Coiled-coil domain-containing protein 40

1

0

High-throughput

0.279

Low

1198472

CEP55
Centrosomal protein of 55 kDa

1

0

High-throughput

0.279

Low

1201822

SDK2
Protein sidekick-2

1

0

High-throughput

0.279

Low

1206107

TGO1
Transport and Golgi organization protein 1 homolog

1

0

High-throughput

0.279

Low

1210083

SNP47
Synaptosomal-associated protein 47

1

0

High-throughput

0.279

Low

1311350

ANKH1
Ankyrin repeat and KH domain-containing protein 1

1

0

High-throughput

0.279

Low

1338086

NAV1
Neuron navigator 1

1

0

High-throughput

0.279

Low

1351259

BL1S5
Biogenesis of lysosome-related organelles complex 1 subunit 5

1

0

High-throughput

0.279

Low

1357187

BRI3B
BRI3-binding protein

1

0

High-throughput

0.279

Low

1357190

BORC5
BLOC-1-related complex subunit 5

1

0

High-throughput

0.279

Low

1357191

BORC7
BLOC-1-related complex subunit 7

1

0

High-throughput

0.279

Low

1357207

SRCN1
SRC kinase signaling inhibitor 1

1

0

High-throughput

0.279

Low

1357223

GHRL
Appetite-regulating hormone

1

0

High-throughput

0.279

Low

1357226

ODF2L
Protein BCAP

1

0

High-throughput

0.279

Low

1357234

COG6
Conserved oligomeric Golgi complex subunit 6

1

0

High-throughput

0.279

Low

1357237

DTNA
Dystrobrevin alpha

1

0

High-throughput

0.279

Low

47381

A0A6Q8PF08
Peripheral myelin protein 22

1

0

High-throughput

0.268

Low

166687

BCKD
Branched-chain alpha-ketoacid dehydrogenase kinase

1

0

High-throughput

0.268

Low

211655

ZNHI1
Zinc finger HIT domain-containing protein 1

1

0

High-throughput

0.268

Low

238726

TIM8A
Mitochondrial import inner membrane translocase subunit Tim8 A

1

0

High-throughput

0.268

Low

331515

SPDEF
SAM pointed domain-containing Ets transcription factor

1

0

High-throughput

0.268

Low

339281

MPC2
Mitochondrial pyruvate carrier 2

1

0

High-throughput

0.268

Low

479609

DOPO
Dopamine beta-hydroxylase

1

0

High-throughput

0.268

Low

622225

NDUV2
NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial

1

0

High-throughput

0.268

Low

833843

P2RY2
P2Y purinoceptor 2

1

0

High-throughput

0.268

Low

852811

VDAC2
Non-selective voltage-gated ion channel VDAC2

1

0

High-throughput

0.268

Low

996786

TBA1B
Tubulin alpha-1B chain

1

0

High-throughput

0.268

Low

1081592

BRME1
Break repair meiotic recombinase recruitment factor 1

1

0

High-throughput

0.268

Low

1136719

LAP4A
Lysosomal-associated transmembrane protein 4A

1

0

High-throughput

0.268

Low

1185886

TMM95
Sperm-egg fusion protein TMEM95

1

0

High-throughput

0.268

Low

1213572

PHF19
PHD finger protein 19

1

0

High-throughput

0.268

Low

1289848

Q86V28
AP-1 complex subunit gamma

1

0

High-throughput

0.268

Low

1313665

IFT20
Intraflagellar transport protein 20 homolog

1

0

High-throughput

0.268

Low

1322196

VKORL
Vitamin K epoxide reductase complex subunit 1-like protein 1

1

0

High-throughput

0.268

Low

1326009

RYBP
RING1 and YY1-binding protein

1

0

High-throughput

0.268

Low

1330709

MAGB6
Melanoma-associated antigen B6

1

0

High-throughput

0.268

Low

1347608

Q8TAS3
PRRG2 protein

1

0

High-throughput

0.268

Low

1350018

SPP2B
Signal peptide peptidase-like 2B

1

0

High-throughput

0.268

Low

1350224

WFDC5
WAP four-disulfide core domain protein 5

1

0

High-throughput

0.268

Low

1357186

JPH3
Junctophilin-3

1

0

High-throughput

0.268

Low

1357202

ZNG1A
Zinc-regulated GTPase metalloprotein activator 1A

1

0

High-throughput

0.268

Low

1357210

CFA68
Cilia- and flagella-associated protein 68

1

0

High-throughput

0.268

Low

261845

PFD1
Prefoldin subunit 1

1

0

High-throughput

0.265

Low

598756

ANFB
Natriuretic peptides B

1

0

High-throughput

0.232

Low

1032074

CAC1D
Voltage-dependent L-type calcium channel subunit alpha-1D

1

0

Small-scale

0.232

Low

1258523

CR3L2
Cyclic AMP-responsive element-binding protein 3-like protein 2

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025