HitPredict

Interactor 1: UBE2U (Q5VVX9)
Ubiquitin-conjugating enzyme E2 U (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme U) (Ubiquitin carrier protein U) (Ubiquitin-protein ligase U)
Gene: UBE2U

Interactor 2: TRI46 (Q7Z4K8)
Tripartite motif-containing protein 46 (Gene Y protein) (GeneY) (Tripartite, fibronectin type-III and C-terminal SPRY motif protein)
Gene: TRIM46

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.48	0.80	0.625

Property	Details
Experiments	19549727
Identification Methods	two hybrid, two hybrid array
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	UQ_con~zf-RING_UBOX
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 321 Hs			1 759
+	Hs
		1138879 UBE2U_HUMAN (1-321): 7.67e-166: 465: 100.00		Q6GX22_HUMAN (24-749): 3.27e-111: 354: 18.75
+	Hs
		1138928 UBE2U_HUMAN (1-321): 7.67e-166: 465: 100.00		TRIM1_HUMAN (85-749): 6.26e-101: 329: 19.46
+	Hs
		1138921 UBE2U_HUMAN (1-321): 7.67e-166: 465: 100.00		TRIM2_HUMAN (141-717): 4.1e-74: 257: 12.05
+	Hs
		1138880 UBE2U_HUMAN (1-321): 7.67e-166: 465: 100.00		Q6NR77_HUMAN (15-426): 6.65e-66: 224: 23.33
+	Hs
		1138897 UBE2U_HUMAN (1-321): 7.67e-166: 465: 100.00		TRI63_HUMAN (15-426): 1.19e-65: 223: 23.10
+	Hs
		1138918 UBE2U_HUMAN (1-321): 7.67e-166: 465: 100.00		TRI54_HUMAN (10-428): 1.15e-61: 212: 21.50
+	Hs
		175730 UB2D4_HUMAN (4-153): 2.99e-76: 231: 31.33		TRI18_HUMAN (24-750): 1.62e-116: 368: 21.15
+	Hs
		1138920 UBE2U_HUMAN (1-321): 7.67e-166: 465: 100.00		TRIM5_HUMAN (19-144): 2.82e-29: 124: 20.31
+	Hs
		1151762 UB2D4_HUMAN (4-153): 2.99e-76: 231: 31.33		Q6GX22_HUMAN (24-749): 3.27e-111: 354: 18.75
+	Hs
		170390 UBE2U_HUMAN (1-321): 7.67e-166: 465: 100.00		TIF1A_HUMAN (32-408): 8.32e-26: 116: 15.68
+	Hs
		1138878 UBE2U_HUMAN (1-321): 7.67e-166: 465: 100.00		TRI68_HUMAN (19-149): 2.38e-25: 112: 16.18
+	Hs
		536873 UBE2U_HUMAN (1-321): 7.67e-166: 465: 100.00		TRI27_HUMAN (19-149): 3.94e-25: 112: 21.32
+	Hs
		262178 UBE2U_HUMAN (1-321): 7.67e-166: 465: 100.00		TRIM3_HUMAN (14-149): 4.03e-12: 71.7: 16.67
+	Hs
		1052807 UB2D4_HUMAN (4-153): 2.99e-76: 231: 31.33		TRI25_HUMAN (27-748): 5.47e-85: 283: 12.52
+	Hs
		1317493 UB2D4_HUMAN (4-153): 2.99e-76: 231: 31.33		TRI54_HUMAN (10-428): 1.15e-61: 212: 21.50
+	Hs
		1318719 UB2D4_HUMAN (4-153): 2.99e-76: 231: 31.33		TRIM5_HUMAN (19-144): 2.82e-29: 124: 20.31
+	Hs
		1318358 UB2D4_HUMAN (4-153): 2.99e-76: 231: 31.33		TRIM8_HUMAN (127-398): 2.92e-25: 112: 22.14
+	Hs
		537142 UB2D4_HUMAN (4-153): 2.99e-76: 231: 31.33		TRI27_HUMAN (19-149): 3.94e-25: 112: 21.32
+	Hs
		1285831 UB2D4_HUMAN (4-153): 2.99e-76: 231: 31.33		TRI43_HUMAN (326-728): 2.09e-15: 81.2: 12.29
+	Hs
		262201 UB2D4_HUMAN (4-153): 2.99e-76: 231: 31.33		TRIM3_HUMAN (14-149): 4.03e-12: 71.7: 16.67