HitPredict

Interactor 1: SHE (Q5VZ18)
SH2 domain-containing adapter protein E
Gene: SHE

Interactor 2: DOK3 (Q7L591)
Docking protein 3 (Downstream of tyrosine kinase 3)
Gene: DOK3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.58	0.50	0.542

Property	Details
Experiments	25814554, unassigned1126
Identification Methods	two hybrid, two hybrid array, validated two hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 495 Hs			1 496
+	Hs
		1184732 SHC3_HUMAN (206-493): 7.69e-54: 192: 20.07		DOK3_HUMAN (1-496): 0: 539: 100.00
+	Hs
		209149 NCK2_HUMAN (83-492): 2.07e-61: 207: 15.98		DOK1_HUMAN (60-491): 1.13e-123: 371: 29.92
+	Mm
		223011 NCK2_MOUSE (83-492): 5.82e-59: 201: 15.74		DOK1_MOUSE (60-491): 4.19e-125: 375: 30.19
+	Mm
		956524 NCK1_MOUSE (83-490): 3.68e-59: 201: 14.36		DOK1_MOUSE (60-491): 4.19e-125: 375: 30.19
+	Hs
		557780 NCK1_HUMAN (83-490): 8.88e-60: 203: 14.60		DOK1_HUMAN (60-491): 1.13e-123: 371: 29.92
+	Rn
		250473 SHC3_RAT (206-493): 9.34e-53: 189: 19.08		DOK1_RAT (60-490): 3.31e-127: 380: 29.61
+	Hs
		666161 SHC1_HUMAN (200-494): 1.12e-45: 170: 16.84		DOK1_HUMAN (60-491): 1.13e-123: 371: 29.92
+	Hs
		208960 NCK2_HUMAN (83-492): 2.07e-61: 207: 15.98		DOK2_HUMAN (61-455): 2.1e-95: 296: 34.04
+	Hs
		208999 NCK2_HUMAN (83-492): 2.07e-61: 207: 15.98		IRS1_HUMAN (65-494): 2.85e-88: 296: 15.58
+	Hs
		235041 NCK1_HUMAN (83-490): 8.88e-60: 203: 14.60		DOK2_HUMAN (61-455): 2.1e-95: 296: 34.04
+	Hs
		147457 SOCS6_HUMAN (62-495): 9.2e-54: 191: 14.57		IRS4_HUMAN (65-427): 3e-89: 298: 15.90
+	Mm
		223005 NCK2_MOUSE (83-492): 5.82e-59: 201: 15.74		DOK2_MOUSE (61-455): 8.61e-90: 282: 31.05
+	Mm
		250957 NCK1_MOUSE (83-490): 3.68e-59: 201: 14.36		DOK2_MOUSE (61-455): 8.61e-90: 282: 31.05
+	Mm
		724592 SHC1_MOUSE (200-494): 1.76e-48: 177: 17.51		IRS1_MOUSE (65-494): 2.12e-87: 293: 15.32
+	Hs
		151717 SHC1_HUMAN (200-494): 1.12e-45: 170: 16.84		IRS4_HUMAN (65-427): 3e-89: 298: 15.90
+	Rn
		292432 GRB14_RAT (181-492): 3.55e-47: 173: 14.67		IRS1_RAT (65-494): 4.24e-88: 295: 15.32
+	Hs
		235049 SHC1_HUMAN (200-494): 1.12e-45: 170: 16.84		DOK2_HUMAN (61-455): 2.1e-95: 296: 34.04
+	Dm
		1360394 SRC42_DROME (251-490): 5.15e-47: 172: 16.33		Q9W3R6_DROME (60-333): 1.17e-61: 214: 21.99
+	Hs
		147460 SOCS6_HUMAN (62-495): 9.2e-54: 191: 14.57		FRS3_HUMAN (198-454): 5.09e-51: 182: 20.58
+	Hs
		207315 GRB14_HUMAN (181-492): 1.06e-46: 172: 13.81		FRS3_HUMAN (198-454): 5.09e-51: 182: 20.58