Protein: MED8
Mediator of RNA polymerase II transcription subunit 8 (Activator-recruited cofactor 32 kDa component) (ARC32) (Mediator complex subunit 8)

Gene: MED8
Organism: Homo sapiens
Interactions: 101
UniProt ID: Q96G25

Gene Ontology (top 5):
GO:0000151 - ubiquitin ligase complex
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0003712 - transcription coregulator activity
GO:0005634 - nucleus
GO:0005654 - nucleoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

206639

MED7
Mediator of RNA polymerase II transcription subunit 7

5

1

High-throughput

0.932

High

1291842

MED18
Mediator of RNA polymerase II transcription subunit 18

5

1

High-throughput

0.932

High

1291849

MED17
Mediator of RNA polymerase II transcription subunit 17

3

1

High-throughput

0.871

High

1291852

MED11
Mediator of RNA polymerase II transcription subunit 11

3

2

High-throughput

0.855

High

1074717

MED22
Mediator of RNA polymerase II transcription subunit 22

3

0

High-throughput

0.816

High

270522

MED6
Mediator of RNA polymerase II transcription subunit 6

2

1

High-throughput

0.789

High

181442

RPB4
DNA-directed RNA polymerase II subunit RPB4

2

0

High-throughput

0.770

High

1291856

MED31
Mediator of RNA polymerase II transcription subunit 31

2

0

High-throughput

0.770

High

48711

MED19
Mediator of RNA polymerase II transcription subunit 19

10

1

Small-scale

0.758

High

1291841

MED10
Mediator of RNA polymerase II transcription subunit 10

9

1

Small-scale

0.757

High

826334

CDK8
Cyclin-dependent kinase 8

9

3

High-throughput

0.754

High

1291851

MED29
Mediator of RNA polymerase II transcription subunit 29

7

1

Small-scale

0.750

High

1291843

CDK19
Cyclin-dependent kinase 19

6

3

High-throughput

0.733

High

1274328

MED12
Mediator of RNA polymerase II transcription subunit 12

5

1

High-throughput

0.714

High

1076185

MED1
Mediator of RNA polymerase II transcription subunit 1

6

0

Small-scale

0.702

High

1291846

MED20
Mediator of RNA polymerase II transcription subunit 20

4

1

High-throughput

0.702

High

1291847

MED4
Mediator of RNA polymerase II transcription subunit 4

4

1

High-throughput

0.702

High

1291844

MED28
Mediator of RNA polymerase II transcription subunit 28

6

0

Small-scale

0.699

High

1291837

MED30
Mediator of RNA polymerase II transcription subunit 30

4

2

Small-scale

0.696

High

1291850

MED9
Mediator of RNA polymerase II transcription subunit 9

5

0

Small-scale

0.688

High

624485

CCNC
Cyclin-C

4

1

High-throughput

0.686

High

1037083

MED21
Mediator of RNA polymerase II transcription subunit 21

4

0

High-throughput

0.674

High

1291854

MED23
Mediator of RNA polymerase II transcription subunit 23

3

1

High-throughput

0.667

High

1158910

MED27
Mediator of RNA polymerase II transcription subunit 27

3

1

Small-scale

0.656

High

265352

MED24
Mediator of RNA polymerase II transcription subunit 24

3

0

High-throughput

0.638

High

313454

MED26
Mediator of RNA polymerase II transcription subunit 26

3

0

High-throughput

0.638

High

225407

MED14
Mediator of RNA polymerase II transcription subunit 14

2

2

High-throughput

0.611

High

1291855

MED16
Mediator of RNA polymerase II transcription subunit 16

2

1

High-throughput

0.611

High

177713

BIRC5
Baculoviral IAP repeat-containing protein 5

2

0

High-throughput

0.602

High

1291853

MED13
Mediator of RNA polymerase II transcription subunit 13

2

2

High-throughput

0.601

High

583545

RPB3
DNA-directed RNA polymerase II subunit RPB3

2

0

High-throughput

0.585

High

624993

RPB1
DNA-directed RNA polymerase II subunit RPB1

2

0

High-throughput

0.585

High

676965

RPB2
DNA-directed RNA polymerase II subunit RPB2

2

0

High-throughput

0.585

High

370195

ESR1
Estrogen receptor

2

5

High-throughput

0.571

High

1174765

MD13L
Mediator of RNA polymerase II transcription subunit 13-like

2

2

High-throughput

0.571

High

1072420

ELOB
Elongin-B

1

0

Small-scale

0.568

High

1072283

ELOC
Elongin-C

1

1

Small-scale

0.562

High

1281307

FBXW7
F-box/WD repeat-containing protein 7

2

0

Small-scale

0.559

High

262069

PEX14
Peroxisomal membrane protein PEX14

1

0

High-throughput

0.518

High

686031

ARRB2
Beta-arrestin-2

1

0

High-throughput

0.518

High

1022267

HSPB3
Heat shock protein beta-3

1

0

High-throughput

0.518

High

382107

G3P
Glyceraldehyde-3-phosphate dehydrogenase

1

0

High-throughput

0.513

High

583765

RPAB1
DNA-directed RNA polymerases I, II, and III subunit RPABC1

1

0

High-throughput

0.513

High

638371

RBTN2
Rhombotin-2

1

0

High-throughput

0.513

High

921386

RBX1
E3 ubiquitin-protein ligase RBX1

1

0

Small-scale

0.513

High

1160882

FXL19
F-box/LRR-repeat protein 19

1

0

High-throughput

0.513

High

831584

CEBPA
CCAAT/enhancer-binding protein alpha

1

0

High-throughput

0.505

High

395465

A4
Amyloid-beta precursor protein

1

0

High-throughput

0.480

High

1151839

THOC7
THO complex subunit 7 homolog

1

0

Small-scale

0.480

High

1291857

CTDP1
RNA polymerase II subunit A C-terminal domain phosphatase

1

0

Small-scale

0.480

High

266408

TAD2A
Transcriptional adapter 2-alpha

1

2

High-throughput

0.479

High

347577

MYC
Myc proto-oncogene protein

1

2

High-throughput

0.479

High

377585

GCR
Glucocorticoid receptor

1

6

High-throughput

0.479

High

487671

ANDR
Androgen receptor

1

5

High-throughput

0.479

High

782628

HNF4A
Hepatocyte nuclear factor 4-alpha

1

6

High-throughput

0.479

High

1206152

MD12L
Mediator of RNA polymerase II transcription subunit 12-like protein

1

1

High-throughput

0.479

High

1291838

MED15
Mediator of RNA polymerase II transcription subunit 15

1

1

High-throughput

0.479

High

1291840

EPAS1
Endothelial PAS domain-containing protein 1

1

1

Small-scale

0.479

High

171065

TBXT
T-box transcription factor T

1

0

High-throughput

0.458

High

244779

BRD4
Bromodomain-containing protein 4

1

0

High-throughput

0.458

High

295549

RECQ5
ATP-dependent DNA helicase Q5

1

0

High-throughput

0.458

High

304648

SCAF4
SR-related and CTD-associated factor 4

1

0

High-throughput

0.458

High

345520

FOS
Protein c-Fos

1

0

High-throughput

0.458

High

546029

MYOD1
Myoblast determination protein 1

1

0

High-throughput

0.458

High

668905

PML
Protein PML

1

0

High-throughput

0.458

High

738867

RPB9
DNA-directed RNA polymerase II subunit RPB9

1

0

High-throughput

0.458

High

808843

YAP1
Transcriptional coactivator YAP1

1

0

High-throughput

0.458

High

854343

RPAB3
DNA-directed RNA polymerases I, II, and III subunit RPABC3

1

0

High-throughput

0.458

High

854451

RPB11
DNA-directed RNA polymerase II subunit RPB11-a

1

0

High-throughput

0.458

High

864970

RPAB4
DNA-directed RNA polymerases I, II, and III subunit RPABC4

1

0

High-throughput

0.458

High

897597

RPAB2
DNA-directed RNA polymerases I, II, and III subunit RPABC2

1

0

High-throughput

0.458

High

913935

RPB7
DNA-directed RNA polymerase II subunit RPB7

1

0

High-throughput

0.458

High

921146

RPAB5
DNA-directed RNA polymerases I, II, and III subunit RPABC5

1

0

High-throughput

0.458

High

967351

EWS
RNA-binding protein EWS

1

0

High-throughput

0.458

High

1019076

TP53B
TP53-binding protein 1

1

0

High-throughput

0.458

High

1041433

CUL2
Cullin-2

1

0

Small-scale

0.458

High

1076273

TRIP4
Activating signal cointegrator 1

1

0

High-throughput

0.458

High

1132724

ZC3HD
Zinc finger CCCH domain-containing protein 13

1

0

High-throughput

0.458

High

1137941

RPRD2
Regulation of nuclear pre-mRNA domain-containing protein 2

1

0

High-throughput

0.458

High

1173752

ACD11
Acyl-CoA dehydrogenase family member 11

1

0

High-throughput

0.458

High

1221343

RPAP2
Putative RNA polymerase II subunit B1 CTD phosphatase RPAP2

1

0

High-throughput

0.458

High

1291845

STN1
CST complex subunit STN1

1

0

High-throughput

0.458

High

73036

B4DUB1
cDNA FLJ50029, highly similar to Cell division cycle 2-like protein kinase 6

1

3

High-throughput

0.445

High

91305

E5RFK5
Cyclin-C

1

1

High-throughput

0.445

High

500443

THA
Thyroid hormone receptor alpha

1

5

Small-scale

0.445

High

1146723

A16L1
Autophagy-related protein 16-1

1

1

High-throughput

0.437

High

321167

PTBP3
Polypyrimidine tract-binding protein 3

1

0

High-throughput

0.426

High

1291839

NUDC1
NudC domain-containing protein 1

1

0

High-throughput

0.426

High

329040

TCL1B
T-cell leukemia/lymphoma protein 1B

3

0

High-throughput

0.347

High

679290

KAP1
cAMP-dependent protein kinase type I-beta regulatory subunit

2

0

High-throughput

0.316

High

1149281

K1C40
Keratin, type I cytoskeletal 40

1

0

High-throughput

0.299

High

1242265

PNMA1
Paraneoplastic antigen Ma1

1

0

High-throughput

0.299

High

1267328

PHYIP
Phytanoyl-CoA hydroxylase-interacting protein

1

0

High-throughput

0.282

High

486308

CCL3
C-C motif chemokine 3

1

0

High-throughput

0.279

Low

1252852

ZCH10
Zinc finger CCHC domain-containing protein 10

1

0

High-throughput

0.279

Low

361597

APOA2
Apolipoprotein A-II

1

0

High-throughput

0.249

Low

1150678

GL1AD
DNA-directed RNA polymerase II subunit GRINL1A, isoforms 4/5

1

0

High-throughput

0.249

Low

1033847

SNTA1
Alpha-1-syntrophin

1

0

High-throughput

0.238

Low

1251849

UBAD1
UBA-like domain-containing protein 1

1

0

High-throughput

0.238

Low

1291848

DISC1
Disrupted in schizophrenia 1 protein

1

0

High-throughput

0.238

Low

473913

GRL1A
DNA-directed RNA polymerase II subunit GRINL1A

1

0

High-throughput

0.232

Low


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Last updated: 15 Jul 2024