HitPredict

Interactor 1: GRB2 (Q60631)
Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2)
Gene: GRB2

Interactor 2: LCP2 (Q60787)
Lymphocyte cytosolic protein 2 (SH2 domain-containing leukocyte protein of 76 kDa) (SLP-76 tyrosine phosphoprotein) (SLP76)
Gene: LCP2

Species: Mus musculus

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	1.00	0.755

Property	Details
Experiments	7706237, 24584089
Identification Methods	pull down, affinity chromatography technology
Interaction Type	direct interaction, association

Property	Details
Interacting Pfam domains	SH2~SH2, SH2~SH3_1
Common GO terms	GO:0005829 - cytosol GO:0005911 - cell-cell junction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 217 Mm			1 533
+	Hs
		924534 GRB2_HUMAN (1-217): 6.92e-74: 224: 99.54		LCP2_HUMAN (1-531): 2.21e-75: 249: 80.98
+	Hs
		411700 LCK_HUMAN (3-202): 7.66e-38: 138: 28.91		LCP2_HUMAN (1-531): 2.21e-75: 249: 80.98
+	Hs
		924670 GRB2_HUMAN (1-217): 6.92e-74: 224: 99.54		CLNK_HUMAN (302-528): 3.63e-43: 160: 31.22
+	Hs
		924727 GRB2_HUMAN (1-217): 6.92e-74: 224: 99.54		BLNK_HUMAN (52-520): 3.13e-36: 142: 22.80
+	Mm
		222321 GRB2_MOUSE (1-217): 3.97e-74: 225: 100.00		O54737_MOUSE (52-523): 2.87e-32: 131: 20.79
+	Mm
		1141384 NCK1_MOUSE (5-145): 8.99e-23: 96.3: 33.14		LCP2_MOUSE (1-533): 2.96e-77: 254: 100.00
+	Hs
		203218 GRB2_HUMAN (1-217): 6.92e-74: 224: 99.54		SYNJ1_HUMAN (10-467): 2.51e-29: 125: 9.82
+	Hs
		557674 NCK1_HUMAN (5-145): 9.45e-23: 96.3: 33.14		LCP2_HUMAN (1-531): 2.21e-75: 249: 80.98
+	Hs
		924632 GRB2_HUMAN (1-217): 6.92e-74: 224: 99.54		TENS2_HUMAN (86-512): 5.89e-22: 102: 15.79
+	Hs
		924703 GRB2_HUMAN (1-217): 6.92e-74: 224: 99.54		MINK1_HUMAN (115-411): 2.89e-21: 100: 14.98
+	Hs
		554292 GRB2_HUMAN (1-217): 6.92e-74: 224: 99.54		MUC1_HUMAN (92-442): 2.35e-14: 78.2: 11.55
+	Hs
		924760 GRB2_HUMAN (1-217): 6.92e-74: 224: 99.54		PRG4_HUMAN (107-461): 1.69e-09: 62.8: 12.33
+	Mm
		639462 LYN_MOUSE (3-202): 3.06e-38: 140: 27.49		CLNK_MOUSE (170-528): 4.86e-35: 138: 25.20
+	Hs
		203198 LCK_HUMAN (3-202): 7.66e-38: 138: 28.91		SYNJ1_HUMAN (10-467): 2.51e-29: 125: 9.82
+	Hs
		411790 LCK_HUMAN (3-202): 7.66e-38: 138: 28.91		MINK1_HUMAN (115-411): 2.89e-21: 100: 14.98
+	Hs
		203208 NCK1_HUMAN (5-145): 9.45e-23: 96.3: 33.14		SYNJ1_HUMAN (10-467): 2.51e-29: 125: 9.82
+	Hs
		411582 LCK_HUMAN (3-202): 7.66e-38: 138: 28.91		MUC1_HUMAN (92-442): 2.35e-14: 78.2: 11.55
+	Hs
		782797 CSK_HUMAN (2-139): 4.25e-24: 100: 36.24		TENS3_HUMAN (52-512): 1.47e-26: 116: 12.63
+	Hs
		782795 CSK_HUMAN (2-139): 4.25e-24: 100: 36.24		TENS2_HUMAN (86-512): 5.89e-22: 102: 15.79
+	Hs
		782828 CSK_HUMAN (2-139): 4.25e-24: 100: 36.24		TENS1_HUMAN (65-512): 5.51e-21: 99.4: 13.11