Protein: IKBA
NF-kappa-B inhibitor alpha (I-kappa-B-alpha) (IkB-alpha) (IkappaBalpha) (Major histocompatibility complex enhancer-binding protein MAD3)

Gene: IKBA, NFKBIA
Organism: Homo sapiens
Interactions: 230
UniProt ID: P25963

Gene Ontology (top 5):
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0005886 - plasma membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

639733

TF65
Transcription factor p65

89

20

Small-scale

0.998

High

158400

IKKB
Inhibitor of nuclear factor kappa-B kinase subunit beta

82

20

Small-scale

0.998

High

167475

IKKA
Inhibitor of nuclear factor kappa-B kinase subunit alpha

66

20

Small-scale

0.997

High

587427

NFKB1
Nuclear factor NF-kappa-B p105 subunit

32

20

Small-scale

0.993

High

639834

NEMO
NF-kappa-B essential modulator

28

20

Small-scale

0.992

High

639734

REL
Proto-oncogene c-Rel

12

20

Small-scale

0.978

High

639729

NFKB2
Nuclear factor NF-kappa-B p100 subunit

7

19

Small-scale

0.966

High

639731

RELB
Transcription factor RelB

8

20

Small-scale

0.964

High

639706

TERA
Transitional endoplasmic reticulum ATPase

7

12

Small-scale

0.959

High

639750

IKBB
NF-kappa-B inhibitor beta

5

16

Small-scale

0.931

High

616128

RS3
Small ribosomal subunit protein uS3

5

2

Small-scale

0.925

High

522789

SRC
Proto-oncogene tyrosine-protein kinase Src

4

12

Small-scale

0.895

High

639745

IKKE
Inhibitor of nuclear factor kappa-B kinase subunit epsilon

4

20

Small-scale

0.888

High

639674

IKBA
NF-kappa-B inhibitor alpha

4

18

Small-scale

0.886

High

386133

P53
Cellular tumor antigen p53

3

9

Small-scale

0.880

High

639749

KS6A1
Ribosomal protein S6 kinase alpha-1

3

10

Small-scale

0.878

High

639746

CASL
Enhancer of filamentation 1

3

14

High-throughput

0.871

High

639714

RHOA
Transforming protein RhoA

3

20

High-throughput

0.861

High

639795

ANR27
Ankyrin repeat domain-containing protein 27

3

20

High-throughput

0.861

High

639818

TBK1
Serine/threonine-protein kinase TBK1

3

20

Small-scale

0.845

High

639747

PLSI
Plastin-1

2

20

High-throughput

0.811

High

639829

FBW1A
F-box/WD repeat-containing protein 1A

29

20

Small-scale

0.769

High

639735

KPCZ
Protein kinase C zeta type

2

16

Small-scale

0.768

High

639819

FBW1B
F-box/WD repeat-containing protein 11

13

20

Small-scale

0.761

High

639700

IRAK1
Interleukin-1 receptor-associated kinase 1

2

4

Small-scale

0.754

High

639721

SKP1
S-phase kinase-associated protein 1

9

6

Small-scale

0.750

High

639744

CUL1
Cullin-1

9

20

Small-scale

0.748

High

639814

HIF1N
Hypoxia-inducible factor 1-alpha inhibitor

5

20

Small-scale

0.724

High

337352

ABL1
Tyrosine-protein kinase ABL1

1

12

Small-scale

0.724

High

639727

CSK21
Casein kinase II subunit alpha

1

9

Small-scale

0.724

High

624775

RPB1
DNA-directed RNA polymerase II subunit RPB1

4

1

Small-scale

0.697

High

639775

COMD1
COMM domain-containing protein 1

4

2

Small-scale

0.694

High

626620

ARBK1
Beta-adrenergic receptor kinase 1

1

13

Small-scale

0.692

High

639684

GRK5
G protein-coupled receptor kinase 5

1

10

Small-scale

0.692

High

121569

IKBE
NF-kappa-B inhibitor epsilon

1

20

High-throughput

0.691

High

639690

MTOR
Serine/threonine-protein kinase mTOR

1

11

Small-scale

0.691

High

639737

PTN13
Tyrosine-protein phosphatase non-receptor type 13

4

20

Small-scale

0.680

High

639694

ARRB1
Beta-arrestin-1

3

3

Small-scale

0.669

High

639725

CSK2B
Casein kinase II subunit beta

3

2

Small-scale

0.667

High

639794

P121A
Nuclear envelope pore membrane protein POM 121

3

8

High-throughput

0.667

High

639751

TBCE
Tubulin-specific chaperone E

3

5

High-throughput

0.667

High

639761

CYTSA
Cytospin-A

3

13

High-throughput

0.667

High

639789

SPDLY
Protein Spindly

3

7

High-throughput

0.667

High

639822

NEB1
Neurabin-1

3

20

High-throughput

0.667

High

639823

TBC24
TBC1 domain family member 24

3

1

High-throughput

0.667

High

127451

RPOM
DNA-directed RNA polymerase, mitochondrial

5

1

Small-scale

0.652

High

639724

UBC9
SUMO-conjugating enzyme UBC9

3

11

Small-scale

0.650

High

160391

AURKA
Aurora kinase A

1

11

Small-scale

0.647

High

548643

VAV
Proto-oncogene vav

1

5

Small-scale

0.647

High

566290

KPCA
Protein kinase C alpha type

1

14

Small-scale

0.647

High

639702

KS6A3
Ribosomal protein S6 kinase alpha-3

1

8

Small-scale

0.647

High

639739

M3K1
Mitogen-activated protein kinase kinase kinase 1

1

6

Small-scale

0.647

High

639797

M3K14
Mitogen-activated protein kinase kinase kinase 14

1

20

Small-scale

0.647

High

638062

PSA4
Proteasome subunit alpha type-4

3

5

Small-scale

0.640

High

639786

AIDA
Axin interactor, dorsalization-associated protein

3

0

High-throughput

0.638

High

639806

ARMT1
Damage-control phosphatase ARMT1

3

0

High-throughput

0.638

High

639679

ARRB2
Beta-arrestin-2

2

3

Small-scale

0.634

High

639791

DNJA3
DnaJ homolog subfamily A member 3, mitochondrial

2

12

Small-scale

0.634

High

305729

ELP1
Elongator complex protein 1

3

0

Small-scale

0.628

High

639762

SUMO4
Small ubiquitin-related modifier 4

2

4

Small-scale

0.625

High

639705

UBP14
Ubiquitin carboxyl-terminal hydrolase 14

2

3

Small-scale

0.624

High

639798

BARD1
BRCA1-associated RING domain protein 1

1

17

Small-scale

0.621

High

639732

CO7A1
Collagen alpha-1(VII) chain

1

7

High-throughput

0.618

High

381128

TBB4A
Tubulin beta-4A chain

1

20

High-throughput

0.618

High

428027

TBB5
Tubulin beta chain

1

20

High-throughput

0.618

High

433258

YES
Tyrosine-protein kinase Yes

1

13

High-throughput

0.618

High

639678

AKT1
RAC-alpha serine/threonine-protein kinase

1

14

Small-scale

0.618

High

639693

KC1A
Casein kinase I isoform alpha

1

9

Small-scale

0.618

High

639709

ARL4C
ADP-ribosylation factor-like protein 4C

1

7

High-throughput

0.618

High

639716

PRS8
26S proteasome regulatory subunit 8

1

5

Small-scale

0.618

High

639717

RAN
GTP-binding nuclear protein Ran

1

9

Small-scale

0.618

High

639753

MK14
Mitogen-activated protein kinase 14

1

10

Small-scale

0.618

High

639763

SFRP4
Secreted frizzled-related protein 4

1

2

Small-scale

0.618

High

639766

TBA1A
Tubulin alpha-1A chain

1

20

High-throughput

0.618

High

639796

ASB2
Ankyrin repeat and SOCS box protein 2

1

20

Small-scale

0.618

High

639811

CISH
Cytokine-inducible SH2-containing protein

1

20

Small-scale

0.618

High

639817

MALT1
Mucosa-associated lymphoid tissue lymphoma translocation protein 1

1

13

Small-scale

0.618

High

639833

NCOR2
Nuclear receptor corepressor 2

2

20

Small-scale

0.612

High

612957

TCEA1
Transcription elongation factor A protein 1

2

6

High-throughput

0.611

High

639722

GBG5

2

1

High-throughput

0.611

High

639740

BIRC2
Baculoviral IAP repeat-containing protein 2

2

20

High-throughput

0.611

High

639810

PRDC1
Phosphoribosyltransferase domain-containing protein 1

2

1

High-throughput

0.611

High

639792

SCRN2
Secernin-2

3

1

High-throughput

0.609

High

639821

OGDHL
2-oxoglutarate dehydrogenase-like, mitochondrial

3

2

High-throughput

0.609

High

198547

PSMD3
26S proteasome non-ATPase regulatory subunit 3

2

2

High-throughput

0.606

High

639707

TCL1A
T-cell leukemia/lymphoma protein 1A

2

1

High-throughput

0.606

High

639710

UB2D3
Ubiquitin-conjugating enzyme E2 D3

2

12

Small-scale

0.602

High

475361

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

2

13

Small-scale

0.601

High

627183

MCM3
DNA replication licensing factor MCM3

2

9

Small-scale

0.601

High

637320

PSA1
Proteasome subunit alpha type-1

2

5

Small-scale

0.601

High

639680

MCM5
DNA replication licensing factor MCM5

2

6

Small-scale

0.601

High

639681

MCM7
DNA replication licensing factor MCM7

2

6

Small-scale

0.601

High

639698

RBP2
E3 SUMO-protein ligase RanBP2

2

4

Small-scale

0.601

High

639782

HDAC2
Histone deacetylase 2

2

20

Small-scale

0.601

High

573574

PTN1
Tyrosine-protein phosphatase non-receptor type 1

2

10

Small-scale

0.595

High

639730

HNRPU
Heterogeneous nuclear ribonucleoprotein U

2

12

Small-scale

0.595

High

639701

UB2D1
Ubiquitin-conjugating enzyme E2 D1

2

12

Small-scale

0.594

High

639781

ASB17
Ankyrin repeat and SOCS box protein 17

1

0

Small-scale

0.586

High

388235

HSPB1
Heat shock protein beta-1

2

5

Small-scale

0.584

High

639736

EP300
Histone acetyltransferase p300

2

11

Small-scale

0.584

High

639738

CSN1
COP9 signalosome complex subunit 1

2

3

Small-scale

0.584

High

639757

TIM50
Mitochondrial import inner membrane translocase subunit TIM50

2

6

Small-scale

0.584

High

639720

DYL1
Dynein light chain 1, cytoplasmic

1

1

Small-scale

0.573

High

639785

PMEPA
Protein TMEPAI

1

1

Small-scale

0.573

High

602800

TGM2
Protein-glutamine gamma-glutamyltransferase 2

2

2

Small-scale

0.571

High

639676

P85A
Phosphatidylinositol 3-kinase regulatory subunit alpha

1

17

Small-scale

0.568

High

453157

ROA1
Heterogeneous nuclear ribonucleoprotein A1

1

4

Small-scale

0.561

High

518089

ADT1
ADP/ATP translocase 1

1

15

Small-scale

0.561

High

639752

NEDD8
NEDD8

1

7

Small-scale

0.561

High

639755

UBE2S
Ubiquitin-conjugating enzyme E2 S

1

13

Small-scale

0.561

High

639759

UBP39
Ubiquitin carboxyl-terminal hydrolase 39

1

4

Small-scale

0.561

High

639773

TRI22
E3 ubiquitin-protein ligase TRIM22

1

10

Small-scale

0.561

High

639825

G3BP2
Ras GTPase-activating protein-binding protein 2

1

5

Small-scale

0.561

High

639718

RL23
Large ribosomal subunit protein uL14

2

0

Small-scale

0.559

High

639741

PIN1
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1

2

0

Small-scale

0.559

High

639824

HECD1
E3 ubiquitin-protein ligase HECTD1

1

10

Small-scale

0.553

High

233742

NDK8
Putative nucleoside diphosphate kinase

2

2

High-throughput

0.552

High

452155

CD7
T-cell antigen CD7

1

2

High-throughput

0.541

High

583397

RPB3
DNA-directed RNA polymerase II subunit RPB3

1

3

High-throughput

0.541

High

639831

RWDD3
RWD domain-containing protein 3

1

0

Small-scale

0.537

High

639685

CTNA1
Catenin alpha-1

1

5

Small-scale

0.536

High

639696

CENPF
Centromere protein F

1

13

High-throughput

0.536

High

639800

RHG39
Rho GTPase-activating protein 39

1

8

High-throughput

0.536

High

639688

CASR
Extracellular calcium-sensing receptor

1

0

Small-scale

0.529

High

48620

MED19
Mediator of RNA polymerase II transcription subunit 19

1

0

High-throughput

0.518

High

183323

MEFV
Pyrin

1

10

Small-scale

0.515

High

261407

NCOR1
Nuclear receptor corepressor 1

1

15

Small-scale

0.515

High

311479

SMC2
Structural maintenance of chromosomes protein 2

1

11

Small-scale

0.515

High

639677

RPB2
DNA-directed RNA polymerase II subunit RPB2

1

6

Small-scale

0.515

High

639687

MDHC
Malate dehydrogenase, cytoplasmic

1

2

High-throughput

0.515

High

639697

NU153
Nuclear pore complex protein Nup153

1

20

Small-scale

0.515

High

639699

SMCA4
Transcription activator BRG1

1

7

Small-scale

0.515

High

639708

HDAC4
Histone deacetylase 4

1

20

Small-scale

0.515

High

639712

CSN2
COP9 signalosome complex subunit 2

1

2

Small-scale

0.515

High

639742

HDAC1
Histone deacetylase 1

1

17

Small-scale

0.515

High

639748

SMC1A
Structural maintenance of chromosomes protein 1A

1

13

Small-scale

0.515

High

639812

SMC4
Structural maintenance of chromosomes protein 4

1

13

Small-scale

0.515

High

639828

HDAC5
Histone deacetylase 5

1

20

Small-scale

0.515

High

639776

AVL9
Late secretory pathway protein AVL9 homolog

1

0

High-throughput

0.513

High

639790

GNA1
Glucosamine 6-phosphate N-acetyltransferase

1

0

High-throughput

0.513

High

639820

MCTS1
Malignant T-cell-amplified sequence 1

1

0

High-throughput

0.513

High

639830

MED31
Mediator of RNA polymerase II transcription subunit 31

1

0

High-throughput

0.513

High

639802

IKZF4
Zinc finger protein Eos

1

2

Small-scale

0.508

High

639816

ZN212
Zinc finger protein 212

1

4

Small-scale

0.508

High

201221

M3K7
Mitogen-activated protein kinase kinase kinase 7

1

9

Small-scale

0.501

High

352498

TNFA
Tumor necrosis factor

1

2

Small-scale

0.501

High

427845

CAN1
Calpain-1 catalytic subunit

1

5

Small-scale

0.501

High

453051

HXB7
Homeobox protein Hox-B7

1

20

Small-scale

0.501

High

524539

LYL1
Protein lyl-1

1

6

Small-scale

0.501

High

637627

PSA2
Proteasome subunit alpha type-2

1

6

Small-scale

0.501

High

639695

UB2R1
Ubiquitin-conjugating enzyme E2 R1

1

10

Small-scale

0.501

High

639711

UBC12
NEDD8-conjugating enzyme Ubc12

1

10

Small-scale

0.501

High

639719

UB2D2
Ubiquitin-conjugating enzyme E2 D2

1

12

Small-scale

0.501

High

639726

UB2L3
Ubiquitin-conjugating enzyme E2 L3

1

11

Small-scale

0.501

High

639832

RN115
E3 ubiquitin-protein ligase RNF115

1

2

Small-scale

0.501

High

639809

ST7
Suppressor of tumorigenicity 7 protein

1

1

High-throughput

0.494

High

579243

ATF4
Cyclic AMP-dependent transcription factor ATF-4

1

0

Small-scale

0.486

High

134701

PIR
Pirin

1

1

Small-scale

0.481

High

639743

ITPK1
Inositol-tetrakisphosphate 1-kinase

1

0

Small-scale

0.480

High

62678

TRI64
Tripartite motif-containing protein 64

1

10

Small-scale

0.479

High

147393

SOCS3
Suppressor of cytokine signaling 3

1

20

Small-scale

0.479

High

162419

XPO1
Exportin-1

1

17

High-throughput

0.479

High

177199

HDAC3
Histone deacetylase 3

1

17

Small-scale

0.479

High

232639

TBCD4
TBC1 domain family member 4

1

1

Small-scale

0.479

High

238056

PDE8A
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A

1

3

Small-scale

0.479

High

312017

ZBT7A
Zinc finger and BTB domain-containing protein 7A

1

5

Small-scale

0.479

High

330232

BCL10
B-cell lymphoma/leukemia 10

1

1

Small-scale

0.479

High

376167

ANXA1
Annexin A1

1

5

High-throughput

0.479

High

397276

ADT2
ADP/ATP translocase 2

1

15

High-throughput

0.479

High

401445

JUN
Transcription factor Jun

1

11

Small-scale

0.479

High

443344

VIME
Vimentin

1

14

Small-scale

0.479

High

450727

F16P1
Fructose-1,6-bisphosphatase 1

1

3

High-throughput

0.479

High

456501

UCHL1
Ubiquitin carboxyl-terminal hydrolase isozyme L1

1

7

Small-scale

0.479

High

500722

CLUS
Clusterin

1

1

Small-scale

0.479

High

501708

BIP
Endoplasmic reticulum chaperone BiP

1

20

High-throughput

0.479

High

503471

HSP7C
Heat shock cognate 71 kDa protein

1

20

High-throughput

0.479

High

536733

TRI27
Zinc finger protein RFP

1

10

Small-scale

0.479

High

639675

ARNT
Aryl hydrocarbon receptor nuclear translocator

1

4

Small-scale

0.479

High

639682

HS71L
Heat shock 70 kDa protein 1-like

1

20

High-throughput

0.479

High

639683

HSP74
Heat shock 70 kDa protein 4

1

20

Small-scale

0.479

High

639686

GRP75
Stress-70 protein, mitochondrial

1

20

High-throughput

0.479

High

639689

STAT1
Signal transducer and activator of transcription 1-alpha/beta

1

8

Small-scale

0.479

High

639691

RS27
Small ribosomal subunit protein eS27

1

6

Small-scale

0.479

High

639692

NEDD4
E3 ubiquitin-protein ligase NEDD4

1

6

Small-scale

0.479

High

639703

RPB11
DNA-directed RNA polymerase II subunit RPB11-a

1

1

High-throughput

0.479

High

639704

ATX3
Ataxin-3

1

1

High-throughput

0.479

High

639713

PHS
Pterin-4-alpha-carbinolamine dehydratase

1

1

High-throughput

0.479

High

639715

SUMO2
Small ubiquitin-related modifier 2

1

4

Small-scale

0.479

High

639723

ACTG
Actin, cytoplasmic 2

1

11

High-throughput

0.479

High

639728

CLH1
Clathrin heavy chain 1

1

6

High-throughput

0.479

High

639754

H31T
Histone H3.1t

1

4

Small-scale

0.479

High

639758

AMOT
Angiomotin

1

18

Small-scale

0.479

High

639760

DCAF6
DDB1- and CUL4-associated factor 6

1

9

High-throughput

0.479

High

639765

MEAK7
MTOR-associated protein MEAK7

1

1

High-throughput

0.479

High

639767

RS27L
Ribosomal protein eS27-like

1

6

High-throughput

0.479

High

639768

MAVS
Mitochondrial antiviral-signaling protein

1

10

Small-scale

0.479

High

639770

RBBP6
E3 ubiquitin-protein ligase RBBP6

1

20

Small-scale

0.479

High

639771

PATL1
Protein PAT1 homolog 1

1

6

Small-scale

0.479

High

639772

RB6I2
ELKS/Rab6-interacting/CAST family member 1

1

6

Small-scale

0.479

High

639774

FBXW8
F-box/WD repeat-containing protein 8

1

20

Small-scale

0.479

High

639777

NEDD1
Protein NEDD1

1

6

Small-scale

0.479

High

639778

COP1
E3 ubiquitin-protein ligase COP1

1

11

Small-scale

0.479

High

639783

UFD1
Ubiquitin recognition factor in ER-associated degradation protein 1

1

1

Small-scale

0.479

High

639784

FBXW7
F-box/WD repeat-containing protein 7

1

20

Small-scale

0.479

High

639788

REPS1
RalBP1-associated Eps domain-containing protein 1

1

16

Small-scale

0.479

High

639799

TRIM8
E3 ubiquitin-protein ligase TRIM8

1

15

Small-scale

0.479

High

639803

RPAP3
RNA polymerase II-associated protein 3

1

14

Small-scale

0.479

High

639804

EGLN3
Prolyl hydroxylase EGLN3

1

6

High-throughput

0.479

High

639808

4ET
Eukaryotic translation initiation factor 4E transporter

1

3

Small-scale

0.479

High

639815

SPRR3
Small proline-rich protein 3

1

5

High-throughput

0.479

High

639826

CSN3
COP9 signalosome complex subunit 3

1

4

Small-scale

0.479

High

639827

Q9UQC1
Heat shock protein 72

1

20

High-throughput

0.479

High

437269

4F2
Amino acid transporter heavy chain SLC3A2

1

0

Small-scale

0.458

High

639756

CTU2
Cytoplasmic tRNA 2-thiolation protein 2

1

0

High-throughput

0.458

High

639779

NPL4
Nuclear protein localization protein 4 homolog

1

0

Small-scale

0.458

High

639780

CHAC2
Glutathione-specific gamma-glutamylcyclotransferase 2

1

0

High-throughput

0.458

High

639787

RN183
E3 ubiquitin-protein ligase RNF183

1

0

Small-scale

0.458

High

639793

OTUB1
Ubiquitin thioesterase OTUB1

1

0

High-throughput

0.458

High

639807

ELP3
Elongator complex protein 3

1

0

High-throughput

0.458

High

102415

G3V3R7
ubiquitinyl hydrolase 1

1

1

High-throughput

0.445

High

68629

CMA1B
Ciliary microtubule associated protein 1B

1

1

Small-scale

0.437

High

639769

TRI46
Tripartite motif-containing protein 46

1

20

Small-scale

0.437

High

207706

DENR
Density-regulated protein

3

0

High-throughput

0.347

High

639813

CUED1
CUE domain-containing protein 1

3

0

High-throughput

0.347

High

639801

ENKD1
Enkurin domain-containing protein 1

2

0

High-throughput

0.316

High

326912

DDAH2
Putative hydrolase DDAH2

1

0

High-throughput

0.279

Low

639764

PTRD1
Putative peptidyl-tRNA hydrolase PTRHD1

1

0

High-throughput

0.279

Low

147973

UBFD1
Ubiquitin domain-containing protein UBFD1

1

0

High-throughput

0.249

Low

639805

RN121
E3 ubiquitin ligase RNF121

1

0

Small-scale

0.249

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024