HitPredict

Interactor 1: GRB2 (Q60631)
Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2)
Gene: GRB2

Interactor 2: DYN3 (Q8BZ98)
Dynamin-3 (EC 3.6.5.5)
Gene: Dnm3

Species: Mus musculus

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.33	1.00	0.575

Property	Details
Experiments	23452850
Identification Methods	anti tag coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	PH~SH3_1
Common GO terms	GO:0005737 - cytoplasm GO:0005886 - plasma membrane GO:0031623 - receptor internalization
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 217 Mm			1 863
+	Hs
		924956 GRB2_HUMAN (1-217): 6.92e-74: 224: 99.54		DYN3_HUMAN (1-863): 0: 1041: 96.33
+	Mm
		760450 GRB2_MOUSE (1-217): 3.97e-74: 225: 100.00		DYN1_MOUSE (1-841): 0: 1019: 78.99
+	Hs
		924499 GRB2_HUMAN (1-217): 6.92e-74: 224: 99.54		DYN1_HUMAN (1-846): 0: 1020: 78.65
+	Hs
		840663 GRB2_HUMAN (1-217): 6.92e-74: 224: 99.54		DYN2_HUMAN (1-863): 0: 1017: 79.04
+	Mm
		760474 GRB2_MOUSE (1-217): 3.97e-74: 225: 100.00		DYN2_MOUSE (1-863): 0: 1014: 79.04
+	Rn
		599402 GRB2_RAT (1-217): 6.92e-74: 224: 99.54		DYN1_RAT (1-846): 0: 1013: 78.41
+	Dm
		649302 GRAP_DROME (1-215): 5.25e-62: 193: 61.86		DYN_DROME (6-855): 0: 963: 64.95
+	Hs
		411645 LCK_HUMAN (3-202): 7.66e-38: 138: 28.91		DYN2_HUMAN (1-863): 0: 1017: 79.04
+	Hs
		337597 ABL1_HUMAN (4-139): 4.39e-22: 95.5: 35.46		DYN3_HUMAN (1-863): 0: 1041: 96.33
+	Hs
		557664 NCK1_HUMAN (5-145): 9.45e-23: 96.3: 33.14		DYN1_HUMAN (1-846): 0: 1020: 78.65
+	Hs
		337437 ABL1_HUMAN (4-139): 4.39e-22: 95.5: 35.46		DYN1_HUMAN (1-846): 0: 1020: 78.65
+	Hs
		337399 ABL1_HUMAN (4-139): 4.39e-22: 95.5: 35.46		DYN2_HUMAN (1-863): 0: 1017: 79.04
+	Hs
		412411 FYN_HUMAN (161-215): 4.88e-13: 69.2: 31.58		DYN3_HUMAN (1-863): 0: 1041: 96.33
+	Hs
		840840 ITSN2_HUMAN (2-61): 3.57e-15: 75.7: 36.67		DYN2_HUMAN (1-863): 0: 1017: 79.04
+	Hs
		412090 FYN_HUMAN (161-215): 4.88e-13: 69.2: 31.58		DYN2_HUMAN (1-863): 0: 1017: 79.04
+	Hs
		840686 GRAP_HUMAN (3-57): 2.36e-13: 68: 36.36		DYN2_HUMAN (1-863): 0: 1017: 79.04
+	Mm
		760469 ITSN1_MOUSE (160-216): 2.45e-11: 64.6: 33.33		DYN1_MOUSE (1-841): 0: 1019: 78.99
+	Hs
		442794 HCK_HUMAN (116-215): 1.24e-11: 64.9: 19.61		DYN2_HUMAN (1-863): 0: 1017: 79.04
+	Ce
		666206 SEM5_CAEEL (3-71): 1.98e-14: 71.5: 28.99		DYN1_CAEEL (3-787): 0: 949: 64.55
+	Ce
		220206 SRC2_CAEEL (126-215): 5.4e-13: 69.2: 23.91		DYN1_CAEEL (3-787): 0: 949: 64.55