Protein: KNOP1
Lysine-rich nucleolar protein 1 (Protein FAM191A) (Testis-specific gene 118 protein)

Gene: KNOP1
Organism: Homo sapiens
Interactions: 234
UniProt ID: Q1ED39

Gene Ontology (top 5):
GO:0003723 - RNA binding
GO:0005730 - nucleolus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

447074

NPM
Nucleophosmin

5

0

High-throughput

0.682

High

975717

RL7A
Large ribosomal subunit protein eL8

4

0

High-throughput

0.664

High

1168599

RL26L
Ribosomal protein uL24-like

3

1

High-throughput

0.650

High

586723

RS2
Small ribosomal subunit protein uS5

3

0

High-throughput

0.638

High

208269

RRP8
Ribosomal RNA-processing protein 8

3

0

High-throughput

0.634

High

686189

RL13
Large ribosomal subunit protein eL13

3

0

High-throughput

0.634

High

969244

RS8
Small ribosomal subunit protein eS8

3

0

High-throughput

0.634

High

345892

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

2

5

High-throughput

0.628

High

355537

NSD2
Histone-lysine N-methyltransferase NSD2

2

1

High-throughput

0.628

High

1168539

SRS12
Serine/arginine-rich splicing factor 12

2

1

High-throughput

0.628

High

1168571

ZN106
Zinc finger protein 106

2

1

High-throughput

0.628

High

1168584

RBM28
RNA-binding protein 28

2

1

High-throughput

0.628

High

978970

RS6
Small ribosomal subunit protein eS6

3

0

High-throughput

0.628

High

810132

RL3
Large ribosomal subunit protein uL3

3

0

High-throughput

0.622

High

643868

FBRL
rRNA 2'-O-methyltransferase fibrillarin

3

0

High-throughput

0.613

High

182306

WDR46
WD repeat-containing protein 46

2

2

High-throughput

0.611

High

1089423

ILF2
Interleukin enhancer-binding factor 2

2

1

High-throughput

0.611

High

1168567

MK67I
MKI67 FHA domain-interacting nucleolar phosphoprotein

2

1

High-throughput

0.611

High

207556

DHX15
ATP-dependent RNA helicase DHX15

2

0

High-throughput

0.602

High

841374

RBM34
RNA-binding protein 34

2

0

High-throughput

0.602

High

959805

RS3A
Small ribosomal subunit protein eS1

2

0

High-throughput

0.602

High

961741

RL37A
Large ribosomal subunit protein eL43

2

0

High-throughput

0.602

High

1117562

NOG2
Nucleolar GTP-binding protein 2

2

0

High-throughput

0.602

High

1148104

PUM3
Pumilio homolog 3

2

0

High-throughput

0.602

High

1168531

SPB1
pre-rRNA 2'-O-ribose RNA methyltransferase FTSJ3

2

0

High-throughput

0.602

High

1168540

DGCR8
Microprocessor complex subunit DGCR8

2

0

High-throughput

0.602

High

1168557

EBP2
Probable rRNA-processing protein EBP2

2

0

High-throughput

0.602

High

1168566

MAK16
Protein MAK16 homolog

2

0

High-throughput

0.602

High

1168573

RPF2
Ribosome production factor 2 homolog

2

0

High-throughput

0.602

High

1168581

SSF1
Suppressor of SWI4 1 homolog

2

0

High-throughput

0.602

High

1168603

RL36
Large ribosomal subunit protein eL36

2

0

High-throughput

0.602

High

1037175

H11
Histone H1.1

3

1

High-throughput

0.593

High

472779

RU17
U1 small nuclear ribonucleoprotein 70 kDa

2

0

High-throughput

0.585

High

984786

RL31
Large ribosomal subunit protein eL31

2

0

High-throughput

0.585

High

1168560

RBM4B
RNA-binding protein 4B

2

0

High-throughput

0.585

High

998373

H31
Histone H3.1

3

2

High-throughput

0.585

High

428789

RLA0
Large ribosomal subunit protein uL10

2

0

High-throughput

0.576

High

1037512

RL18A
Large ribosomal subunit protein eL20

2

0

High-throughput

0.576

High

1168568

REXO4
RNA exonuclease 4

2

0

High-throughput

0.576

High

1168598

ABT1
Activator of basal transcription 1

2

0

High-throughput

0.576

High

1168556

ZN512
Zinc finger protein 512

2

1

High-throughput

0.574

High

1168528

LCA5
Lebercilin

2

0

High-throughput

0.547

High

287003

PRKRA
Interferon-inducible double-stranded RNA-dependent protein kinase activator A

1

5

High-throughput

0.536

High

301074

RL1D1
Ribosomal L1 domain-containing protein 1

1

1

High-throughput

0.536

High

595790

H13
Histone H1.3

1

1

High-throughput

0.536

High

833119

MNDA
Myeloid cell nuclear differentiation antigen

1

1

High-throughput

0.536

High

985189

RL10A
Large ribosomal subunit protein uL1

1

1

High-throughput

0.536

High

1061003

SRSF1
Serine/arginine-rich splicing factor 1

1

3

High-throughput

0.536

High

1062002

SRSF4
Serine/arginine-rich splicing factor 4

1

4

High-throughput

0.536

High

1089687

ILF3
Interleukin enhancer-binding factor 3

1

4

High-throughput

0.536

High

1099098

SRSF5
Serine/arginine-rich splicing factor 5

1

3

High-throughput

0.536

High

1099374

SRSF6
Serine/arginine-rich splicing factor 6

1

5

High-throughput

0.536

High

1168523

ZCCHV
Zinc finger CCCH-type antiviral protein 1

1

2

High-throughput

0.536

High

1168600

RBMX2
RNA-binding motif protein, X-linked 2

1

1

High-throughput

0.536

High

946790

H2B1D
Histone H2B type 1-D

2

8

High-throughput

0.533

High

980800

H2B1C
Histone H2B type 1-C/E/F/G/I

2

8

High-throughput

0.533

High

1016901

H33
Histone H3.3

2

2

High-throughput

0.533

High

1168576

LN28A
Protein lin-28 homolog A

2

0

High-throughput

0.528

High

1168529

ARHGJ
Rho guanine nucleotide exchange factor 19

2

1

High-throughput

0.521

High

250636

HNRPQ
Heterogeneous nuclear ribonucleoprotein Q

1

0

High-throughput

0.513

High

257871

DKC1
H/ACA ribonucleoprotein complex subunit DKC1

1

0

High-throughput

0.513

High

604675

UBF1
Nucleolar transcription factor 1

1

0

High-throughput

0.513

High

615809

RL17
Large ribosomal subunit protein uL22

1

0

High-throughput

0.513

High

785198

RL4
Large ribosomal subunit protein uL4

1

0

High-throughput

0.513

High

809655

RS19
Small ribosomal subunit protein eS19

1

0

High-throughput

0.513

High

824170

RL13A
Large ribosomal subunit protein uL13

1

0

High-throughput

0.513

High

842392

RL35
Large ribosomal subunit protein uL29

1

0

High-throughput

0.513

High

854084

KI67
Proliferation marker protein Ki-67

1

0

High-throughput

0.513

High

855099

NOP2
28S rRNA

1

0

High-throughput

0.513

High

859304

RL5
Large ribosomal subunit protein uL18

1

0

High-throughput

0.513

High

860216

RS9
Small ribosomal subunit protein uS4

1

0

High-throughput

0.513

High

860766

RS10
Small ribosomal subunit protein eS10

1

0

High-throughput

0.513

High

884103

SRP09
Signal recognition particle 9 kDa protein

1

0

High-throughput

0.513

High

898675

RL14
Large ribosomal subunit protein eL14

1

0

High-throughput

0.513

High

961304

RL27
Large ribosomal subunit protein eL27

1

0

High-throughput

0.513

High

969887

RS16
Small ribosomal subunit protein uS9

1

0

High-throughput

0.513

High

978548

RL23A
Large ribosomal subunit protein uL23

1

0

High-throughput

0.513

High

984424

RL30
Large ribosomal subunit protein eL30

1

0

High-throughput

0.513

High

985686

RL11
Large ribosomal subunit protein uL5

1

0

High-throughput

0.513

High

986061

RL8
Large ribosomal subunit protein uL2

1

0

High-throughput

0.513

High

1006433

SRPK2
SRSF protein kinase 2

1

0

High-throughput

0.513

High

1016031

RL19
Large ribosomal subunit protein eL19

1

0

High-throughput

0.513

High

1112036

KRR1
KRR1 small subunit processome component homolog

1

0

High-throughput

0.513

High

1139923

RRS1
Ribosome biogenesis regulatory protein homolog

1

0

High-throughput

0.513

High

1168561

MBB1A
Myb-binding protein 1A

1

0

High-throughput

0.513

High

1168562

LLPH
Protein LLP homolog

1

0

High-throughput

0.513

High

1168569

DDX24
ATP-dependent RNA helicase DDX24

1

0

High-throughput

0.513

High

1168575

DDX31
ATP-dependent DNA helicase DDX31

1

0

High-throughput

0.513

High

1168579

ZCC17
Zinc finger CCHC domain-containing protein 17

1

0

High-throughput

0.513

High

1168580

EXOS4
Exosome complex component RRP41

1

0

High-throughput

0.513

High

1168596

ZN346
Zinc finger protein 346

1

0

High-throughput

0.513

High

1168601

RTCB
RNA-splicing ligase RtcB homolog

1

0

High-throughput

0.513

High

1168604

RBM19
Probable RNA-binding protein 19

1

0

High-throughput

0.513

High

419013

H2A1B
Histone H2A type 1-B/E

1

2

High-throughput

0.489

High

502374

H2A1
Histone H2A type 1

1

2

High-throughput

0.489

High

1168520

ZN574
Zinc finger protein 574

1

1

High-throughput

0.489

High

1168554

ZN668
Zinc finger protein 668

1

1

High-throughput

0.489

High

1168564

H2AJ
Histone H2A.J

1

2

High-throughput

0.489

High

1168591

ZBT47
Zinc finger and BTB domain-containing protein 47

1

1

High-throughput

0.489

High

372165

MYC
Myc proto-oncogene protein

1

1

High-throughput

0.479

High

406234

MYCN
N-myc proto-oncogene protein

1

1

High-throughput

0.479

High

487375

PARP1
Poly [ADP-ribose] polymerase 1

1

2

High-throughput

0.479

High

937266

DSRAD
Double-stranded RNA-specific adenosine deaminase

1

5

High-throughput

0.479

High

1008748

RED1
Double-stranded RNA-specific editase 1

1

3

High-throughput

0.479

High

1088375

CHD3
Chromodomain-helicase-DNA-binding protein 3

1

1

High-throughput

0.479

High

1155423

EZH2
Histone-lysine N-methyltransferase EZH2

1

1

High-throughput

0.479

High

1161463

IF16
Gamma-interferon-inducible protein 16

1

1

High-throughput

0.479

High

1168510

HABP4
Intracellular hyaluronan-binding protein 4

1

1

High-throughput

0.479

High

1168527

ZCH18
Zinc finger CCCH domain-containing protein 18

1

1

High-throughput

0.479

High

1168535

SERB1
SERPINE1 mRNA-binding protein 1

1

1

High-throughput

0.479

High

1168542

KAT6A
Histone acetyltransferase KAT6A

1

2

High-throughput

0.479

High

1168546

UTP4
U3 small nucleolar RNA-associated protein 4 homolog

1

1

High-throughput

0.479

High

1168548

SNR40
U5 small nuclear ribonucleoprotein 40 kDa protein

1

1

High-throughput

0.479

High

140942

NOP56
Nucleolar protein 56

1

0

High-throughput

0.458

High

190928

RPA34
DNA-directed RNA polymerase I subunit RPA34

1

0

High-throughput

0.458

High

693768

RL10
Large ribosomal subunit protein uL16

1

0

High-throughput

0.458

High

697131

APEX1
DNA repair nuclease/redox regulator APEX1

1

0

High-throughput

0.458

High

770196

RL22
Large ribosomal subunit protein eL22

1

0

High-throughput

0.458

High

799908

COIL
Coilin

1

0

High-throughput

0.458

High

885790

KC1E
Casein kinase I isoform epsilon

1

0

High-throughput

0.458

High

886276

ARL4D
ADP-ribosylation factor-like protein 4D

1

0

High-throughput

0.458

High

904784

MECP2
Methyl-CpG-binding protein 2

1

0

High-throughput

0.458

High

979745

H4
Histone H4

1

0

High-throughput

0.458

High

982682

RS24
Small ribosomal subunit protein eS24

1

0

High-throughput

0.458

High

1024605

VIGLN
Vigilin

1

0

High-throughput

0.458

High

1168513

SPOUT
28S rRNA

1

0

High-throughput

0.458

High

1168514

PR38B
Pre-mRNA-splicing factor 38B

1

0

High-throughput

0.458

High

1168532

SRRM1
Serine/arginine repetitive matrix protein 1

1

0

High-throughput

0.458

High

1168544

FBXW7
F-box/WD repeat-containing protein 7

1

0

High-throughput

0.458

High

1168552

DDRGK
DDRGK domain-containing protein 1

1

0

High-throughput

0.458

High

1168565

DDX23
Probable ATP-dependent RNA helicase DDX23

1

0

High-throughput

0.458

High

1168570

RPA49
DNA-directed RNA polymerase I subunit RPA49

1

0

High-throughput

0.458

High

1168585

SLTM
SAFB-like transcription modulator

1

0

High-throughput

0.458

High

1168589

UBP36
Ubiquitin carboxyl-terminal hydrolase 36

1

0

High-throughput

0.458

High

1168593

NOL12
Nucleolar protein 12

1

0

High-throughput

0.458

High

1168602

ZN330
Zinc finger protein 330

1

0

High-throughput

0.458

High

72779

B0UZZ8
WD repeat-containing protein 46

1

2

High-throughput

0.445

High

960129

RL26
Large ribosomal subunit protein uL24

1

1

High-throughput

0.445

High

1144356

NONO
Non-POU domain-containing octamer-binding protein

1

1

High-throughput

0.445

High

209279

PRP4
U4/U6 small nuclear ribonucleoprotein Prp4

1

2

High-throughput

0.437

High

256875

H2B1K
Histone H2B type 1-K

1

8

High-throughput

0.437

High

260030

BRD4
Bromodomain-containing protein 4

1

2

High-throughput

0.437

High

588822

RFA2
Replication protein A 32 kDa subunit

1

1

High-throughput

0.437

High

659898

H2B1O
Histone H2B type 1-O

1

8

High-throughput

0.437

High

674184

BRD2
Bromodomain-containing protein 2

1

2

High-throughput

0.437

High

754863

H2B1B
Histone H2B type 1-B

1

8

High-throughput

0.437

High

871944

PI42A
Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha

1

1

High-throughput

0.437

High

883555

CENPA
Histone H3-like centromeric protein A

1

2

High-throughput

0.437

High

943361

H2BFS
Histone H2B type F-S

1

8

High-throughput

0.437

High

1095261

REST
RE1-silencing transcription factor

1

1

High-throughput

0.437

High

1096708

RFA4
Replication protein A 30 kDa subunit

1

1

High-throughput

0.437

High

1132731

CHD4
Chromodomain-helicase-DNA-binding protein 4

1

1

High-throughput

0.437

High

1141147

BRD3
Bromodomain-containing protein 3

1

2

High-throughput

0.437

High

1168511

H2B2F
Histone H2B type 2-F

1

8

High-throughput

0.437

High

1168524

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

1

High-throughput

0.437

High

1168536

NUP43
Nucleoporin Nup43

1

3

High-throughput

0.437

High

1168537

PI42C
Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma

1

1

High-throughput

0.437

High

1168558

H2B1N
Histone H2B type 1-N

1

8

High-throughput

0.437

High

1168559

H2B1L
Histone H2B type 1-L

1

8

High-throughput

0.437

High

290580

SURF6
Surfeit locus protein 6

1

0

High-throughput

0.426

High

601702

HMGA1
High mobility group protein HMG-I/HMG-Y

1

0

High-throughput

0.426

High

615550

NELFE
Negative elongation factor E

1

0

High-throughput

0.426

High

972430

RS14
Small ribosomal subunit protein uS11

1

0

High-throughput

0.426

High

1130282

RRP1B
Ribosomal RNA processing protein 1 homolog B

1

0

High-throughput

0.426

High

1136784

MO4L2
Mortality factor 4-like protein 2

1

0

High-throughput

0.426

High

1168517

MRM1
rRNA methyltransferase 1, mitochondrial

1

0

High-throughput

0.426

High

1168525

RBM23
Probable RNA-binding protein 23

1

0

High-throughput

0.426

High

1168577

EAF6
Chromatin modification-related protein MEAF6

1

0

High-throughput

0.426

High

1168588

NOP53
Ribosome biogenesis protein NOP53

1

0

High-throughput

0.426

High

1168590

NXF1
Nuclear RNA export factor 1

1

0

High-throughput

0.426

High

342896

HERC2
E3 ubiquitin-protein ligase HERC2

2

0

High-throughput

0.328

High

451516

CENPB
Major centromere autoantigen B

2

0

High-throughput

0.328

High

1168519

SHQ1
Protein SHQ1 homolog

2

0

High-throughput

0.328

High

1168521

CENPU
Centromere protein U

2

0

High-throughput

0.328

High

1168534

ZFP62
Zinc finger protein 62 homolog

2

0

High-throughput

0.328

High

1168550

CENPN
Centromere protein N

2

0

High-throughput

0.328

High

1168574

CH033
UPF0488 protein C8orf33

2

0

High-throughput

0.328

High

1168578

NMNA1
Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1

2

0

High-throughput

0.328

High

1168547

AP2M1
AP-2 complex subunit mu

2

0

High-throughput

0.316

High

191658

MAGB2
Melanoma-associated antigen B2

2

0

High-throughput

0.313

High

396222

ESR1
Estrogen receptor

2

0

High-throughput

0.298

High

1168583

ARHG4
Rho guanine nucleotide exchange factor 4

2

0

High-throughput

0.298

High

169184

QCR10
Cytochrome b-c1 complex subunit 10

1

0

High-throughput

0.279

Low

443069

PTMA
Prothymosin alpha [Cleaved into: Prothymosin alpha, N-terminally processed; Thymosin alpha-1]

1

0

High-throughput

0.279

Low

488054

IFI6
Interferon alpha-inducible protein 6

1

0

High-throughput

0.279

Low

657247

KALM
Anosmin-1

1

0

High-throughput

0.279

Low

788045

ODO2
Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial

1

0

High-throughput

0.279

Low

948531

APC15
Anaphase-promoting complex subunit 15

1

0

High-throughput

0.279

Low

1127392

FGFP1
Fibroblast growth factor-binding protein 1

1

0

High-throughput

0.279

Low

1168508

RN151
RING finger protein 151

1

0

High-throughput

0.279

Low

1168509

GLYR1
Cytokine-like nuclear factor N-PAC

1

0

High-throughput

0.279

Low

1168515

CP141
Cilia- and flagella-associated protein 141

1

0

High-throughput

0.279

Low

1168522

H1FNT
Testis-specific H1 histone

1

0

High-throughput

0.279

Low

1168543

FGF13
Fibroblast growth factor 13

1

0

High-throughput

0.279

Low

1168549

NEIL1
Endonuclease 8-like 1

1

0

High-throughput

0.279

Low

1168533

OTU6B
Deubiquitinase OTUD6B

1

0

Small-scale

0.269

Low

185743

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

1

0

High-throughput

0.261

Low

129133

MEN1
Menin

1

0

High-throughput

0.249

Low

170172

AURKA
Aurora kinase A

1

0

High-throughput

0.249

Low

385797

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

0

High-throughput

0.249

Low

400909

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

0

High-throughput

0.249

Low

695595

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.249

Low

720484

AMRP
Alpha-2-macroglobulin receptor-associated protein

1

0

High-throughput

0.249

Low

768319

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.249

Low

879152

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

0

High-throughput

0.249

Low

970592

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

0

High-throughput

0.249

Low

1097316

CBX3
Chromobox protein homolog 3

1

0

High-throughput

0.249

Low

1124340

ELOA1
Elongin-A

1

0

High-throughput

0.249

Low

1140349

KIF14
Kinesin-like protein KIF14

1

0

High-throughput

0.249

Low

1168512

TEX35
Testis-expressed protein 35

1

0

High-throughput

0.249

Low

1168526

NAA40
N-alpha-acetyltransferase 40

1

0

High-throughput

0.249

Low

1168530

SMC5
Structural maintenance of chromosomes protein 5

1

0

High-throughput

0.249

Low

1168538

DOT1L
Histone-lysine N-methyltransferase, H3 lysine-79 specific

1

0

High-throughput

0.249

Low

1168541

TOPB1
DNA topoisomerase 2-binding protein 1

1

0

High-throughput

0.249

Low

1168545

RL36L
Ribosomal protein eL42-like

1

0

High-throughput

0.249

Low

1168551

PRR11
Proline-rich protein 11

1

0

High-throughput

0.249

Low

1168563

TACO1
Translational activator of cytochrome c oxidase 1

1

0

High-throughput

0.249

Low

1168572

RHOJ
Rho-related GTP-binding protein RhoJ

1

0

High-throughput

0.249

Low

1168582

ANLN
Anillin

1

0

High-throughput

0.249

Low

1168586

AKIP
Small ribosomal subunit protein mS38

1

0

High-throughput

0.249

Low

1168587

TE2IP
Telomeric repeat-binding factor 2-interacting protein 1

1

0

High-throughput

0.249

Low

1168592

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.249

Low

1168594

XPO7
Exportin-7

1

0

High-throughput

0.249

Low

1168595

NUP50
Nuclear pore complex protein Nup50

1

0

High-throughput

0.249

Low

1168597

HECD1
E3 ubiquitin-protein ligase HECTD1

1

0

High-throughput

0.249

Low

1168605

MAFB
Transcription factor MafB

1

0

High-throughput

0.249

Low

47524

RPSA2
Small ribosomal subunit protein uS2B

1

0

High-throughput

0.232

Low

294710

PR15A
Protein phosphatase 1 regulatory subunit 15A

1

0

High-throughput

0.232

Low

391795

SMR3B
Submaxillary gland androgen-regulated protein 3B

1

0

High-throughput

0.232

Low

1144243

PGFRL
Platelet-derived growth factor receptor-like protein

1

0

High-throughput

0.232

Low

1168516

NR3L1
Natural cytotoxicity triggering receptor 3 ligand 1

1

0

High-throughput

0.232

Low

1168518

PSRC1
Proline/serine-rich coiled-coil protein 1

1

0

High-throughput

0.232

Low

1168553

ZN414
Zinc finger protein 414

1

0

High-throughput

0.232

Low

1168555

MF14A
Hippocampus abundant transcript 1 protein

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025