HitPredict

Interactor 1: GRB2 (Q60631)
Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2)
Gene: GRB2

Interactor 2: SH3K1 (Q8R550)
SH3 domain-containing kinase-binding protein 1 (Regulator of ubiquitous kinase) (Ruk) (SH3-containing, expressed in tumorigenic astrocytes)
Gene: Sh3kbp1

Species: Mus musculus

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.34	0.60	0.457

Property	Details
Experiments	15102471
Identification Methods	two hybrid
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005911 - cell-cell junction GO:0017124 - SH3 domain binding GO:0060090 - molecular adaptor activity
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 217 Mm			1 709
+	Hs
		924773 GRB2_HUMAN (1-217): 6.92e-74: 224: 99.54		SH3K1_HUMAN (1-709): 1.41e-127: 395: 88.15
+	Hs
		411817 LCK_HUMAN (3-202): 7.66e-38: 138: 28.91		SH3K1_HUMAN (1-709): 1.41e-127: 395: 88.15
+	Hs
		924988 GRB2_HUMAN (1-217): 6.92e-74: 224: 99.54		CD2AP_HUMAN (1-708): 1.38e-92: 303: 31.06
+	Hs
		337526 ABL1_HUMAN (4-139): 4.39e-22: 95.5: 35.46		SH3K1_HUMAN (1-709): 1.41e-127: 395: 88.15
+	Mm
		1141167 GRB2_MOUSE (1-217): 3.97e-74: 225: 100.00		CD2AP_MOUSE (1-707): 7.06e-77: 261: 29.65
+	Hs
		924630 GRB2_HUMAN (1-217): 6.92e-74: 224: 99.54		SPD2A_HUMAN (3-696): 3.46e-49: 188: 15.01
+	Hs
		337608 ABL1_HUMAN (4-139): 4.39e-22: 95.5: 35.46		CD2AP_HUMAN (1-708): 1.38e-92: 303: 31.06
+	Hs
		51061 GRB2_HUMAN (1-217): 6.92e-74: 224: 99.54		SPD2B_HUMAN (3-649): 1.92e-41: 164: 14.91
+	Hs
		557655 GRB2_HUMAN (1-217): 6.92e-74: 224: 99.54		NCK1_HUMAN (103-384): 1.76e-25: 110: 16.10
+	Hs
		924617 GRB2_HUMAN (1-217): 6.92e-74: 224: 99.54		SH319_HUMAN (5-373): 3.57e-22: 103: 17.34
+	Hs
		924563 GRB2_HUMAN (1-217): 6.92e-74: 224: 99.54		ARHG7_HUMAN (310-394): 1.22e-13: 76.7: 25.88
+	Hs
		69770 GRB2_HUMAN (1-217): 6.92e-74: 224: 99.54		B1ALK7_HUMAN (310-394): 8.74e-13: 73.6: 25.88
+	Hs
		51054 NCK1_HUMAN (5-145): 9.45e-23: 96.3: 33.14		SPD2B_HUMAN (3-649): 1.92e-41: 164: 14.91
+	Hs
		208989 NCK1_HUMAN (5-145): 9.45e-23: 96.3: 33.14		NCK2_HUMAN (103-446): 5.13e-28: 118: 13.64
+	Mm
		337637 ABL1_MOUSE (4-139): 4.43e-22: 95.5: 35.46		NCK1_MOUSE (103-384): 7.94e-26: 112: 16.10
+	Hs
		557594 NCK1_HUMAN (5-145): 9.45e-23: 96.3: 33.14		NCK1_HUMAN (103-384): 1.76e-25: 110: 16.10
+	Hs
		337337 ABL1_HUMAN (4-139): 4.39e-22: 95.5: 35.46		NCK1_HUMAN (103-384): 1.76e-25: 110: 16.10
+	Hs
		557698 NCK1_HUMAN (5-145): 9.45e-23: 96.3: 33.14		ARHG6_HUMAN (262-383): 2.93e-15: 81.7: 23.62
+	Hs
		557687 NCK1_HUMAN (5-145): 9.45e-23: 96.3: 33.14		ARHG7_HUMAN (310-394): 1.22e-13: 76.7: 25.88
+	Hs
		298944 ABL1_HUMAN (4-139): 4.39e-22: 95.5: 35.46		SRBS2_HUMAN (263-507): 9.6e-12: 70.9: 21.24