HitPredict

Interactor 1: GRB2 (Q60631)
Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2)
Gene: GRB2

Interactor 2: SNX18 (Q91ZR2)
Sorting nexin-18 (Sorting nexin-associated Golgi protein 1)
Gene: SNX18

Species: Mus musculus

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.33	0.60	0.445

Property	Details
Experiments	23452850
Identification Methods	anti tag coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 217 Mm			1 614
+	Hs
		924801 GRB2_HUMAN (1-217): 6.92e-74: 224: 99.54		SNX18_HUMAN (1-532): 2.36e-139: 421: 85.56
+	Hs
		433518 YES_HUMAN (75-215): 5.41e-12: 66.1: 18.37		SNX9_HUMAN (1-611): 7.94e-153: 454: 31.97
+	Hs
		275222 GRAP2_HUMAN (3-55): 7.92e-11: 62.5: 39.62		SNX18_HUMAN (1-532): 2.36e-139: 421: 85.56
+	Hs
		924952 GRB2_HUMAN (1-217): 6.92e-74: 224: 99.54		SNX7_HUMAN (232-614): 2.4e-70: 234: 17.47
+	Hs
		924989 GRB2_HUMAN (1-217): 6.92e-74: 224: 99.54		SNX8_HUMAN (227-614): 9.76e-54: 192: 17.23
+	Hs
		411721 LCK_HUMAN (3-202): 7.66e-38: 138: 28.91		CASL_HUMAN (3-539): 1.88e-55: 203: 16.30
+	Hs
		411888 LCK_HUMAN (3-202): 7.66e-38: 138: 28.91		SNX6_HUMAN (235-612): 1.17e-57: 201: 12.23
+	Hs
		557829 NCK1_HUMAN (5-145): 9.45e-23: 96.3: 33.14		SNX7_HUMAN (232-614): 2.4e-70: 234: 17.47
+	Hs
		924951 GRB2_HUMAN (1-217): 6.92e-74: 224: 99.54		SNX12_HUMAN (255-386): 1.1e-16: 79.5: 29.53
+	Hs
		557691 NCK1_HUMAN (5-145): 9.45e-23: 96.3: 33.14		CASL_HUMAN (3-539): 1.88e-55: 203: 16.30
+	Hs
		337474 ABL1_HUMAN (4-139): 4.39e-22: 95.5: 35.46		CASL_HUMAN (3-539): 1.88e-55: 203: 16.30
+	Hs
		557841 NCK1_HUMAN (5-145): 9.45e-23: 96.3: 33.14		SNX8_HUMAN (227-614): 9.76e-54: 192: 17.23
+	Hs
		337609 ABL1_HUMAN (4-139): 4.39e-22: 95.5: 35.46		SNX8_HUMAN (227-614): 9.76e-54: 192: 17.23
+	Hs
		412193 FYN_HUMAN (161-215): 4.88e-13: 69.2: 31.58		CASL_HUMAN (3-539): 1.88e-55: 203: 16.30
+	Hs
		1078937 ITSN1_HUMAN (160-216): 3.02e-11: 64.2: 33.33		SNX5_HUMAN (242-613): 2.12e-59: 205: 13.08
+	Hs
		1078933 ITSN1_HUMAN (160-216): 3.02e-11: 64.2: 33.33		SNX6_HUMAN (235-612): 1.17e-57: 201: 12.23
+	Hs
		412427 FYN_HUMAN (161-215): 4.88e-13: 69.2: 31.58		SNX8_HUMAN (227-614): 9.76e-54: 192: 17.23
+	Hs
		557828 NCK1_HUMAN (5-145): 9.45e-23: 96.3: 33.14		SNX12_HUMAN (255-386): 1.1e-16: 79.5: 29.53
+	Hs
		337593 ABL1_HUMAN (4-139): 4.39e-22: 95.5: 35.46		SNX12_HUMAN (255-386): 1.1e-16: 79.5: 29.53
+	Hs
		412408 FYN_HUMAN (161-215): 4.88e-13: 69.2: 31.58		SNX12_HUMAN (255-386): 1.1e-16: 79.5: 29.53