Protein: FAK2
Protein-tyrosine kinase 2-beta (EC 2.7.10.2) (Calcium-dependent tyrosine kinase) (CADTK) (Calcium-regulated non-receptor proline-rich tyrosine kinase) (Cell adhesion kinase beta) (CAK-beta) (CAKB) (Focal adhesion kinase 2) (FADK 2) (Proline-rich tyrosine kinase 2) (Related adhesion focal tyrosine kinase) (RAFTK)

Gene: FAK2, PTK2B
Organism: Homo sapiens
Interactions: 97
UniProt ID: Q14289

Gene Ontology (top 5):
GO:0000165 - MAPK cascade
GO:0001556 - oocyte maturation
GO:0001666 - response to hypoxia
GO:0001954 - positive regulation of cell-matrix adhesion
GO:0002040 - sprouting angiogenesis

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

823394

PAXI
Paxillin

8

20

Small-scale

0.970

High

412191

FYN
Tyrosine-protein kinase Fyn

6

20

Small-scale

0.950

High

522984

SRC
Proto-oncogene tyrosine-protein kinase Src

6

20

Small-scale

0.944

High

200178

TGFI1
Transforming growth factor beta-1-induced transcript 1 protein

5

20

Small-scale

0.942

High

882292

BCAR1
Breast cancer anti-estrogen resistance protein 1

4

20

Small-scale

0.874

High

338428

EGFR
Epidermal growth factor receptor

4

20

Small-scale

0.867

High

924571

GRB2
Growth factor receptor-bound protein 2

4

20

Small-scale

0.867

High

596401

RASA1
Ras GTPase-activating protein 1

2

20

Small-scale

0.806

High

665889

PTN6
Tyrosine-protein phosphatase non-receptor type 6

2

20

Small-scale

0.806

High

269529

SKAP2
Src kinase-associated phosphoprotein 2

2

20

Small-scale

0.793

High

173582

NPHP1
Nephrocystin-1

2

0

Small-scale

0.765

High

147424

SOCS3
Suppressor of cytokine signaling 3

2

20

Small-scale

0.757

High

985954

PTN11
Tyrosine-protein phosphatase non-receptor type 11

1

20

Small-scale

0.747

High

324804

M4K4
Mitogen-activated protein kinase kinase kinase kinase 4

1

20

Small-scale

0.740

High

195794

ASAP2
Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2

1

20

Small-scale

0.724

High

298979

SRBS2
Sorbin and SH3 domain-containing protein 2

1

20

Small-scale

0.724

High

942340

DLG4
Disks large homolog 4

1

20

Small-scale

0.724

High

1052831

DLG3
Disks large homolog 3

1

20

Small-scale

0.724

High

146627

SOCS2
Suppressor of cytokine signaling 2

1

20

Small-scale

0.713

High

49637

RHG10
Rho GTPase-activating protein 10

1

20

High-throughput

0.691

High

969081

KPCE
Protein kinase C epsilon type

1

20

High-throughput

0.691

High

1052827

RHOU
Rho-related GTP-binding protein RhoU

1

20

Small-scale

0.683

High

537646

NCF1
Neutrophil cytosol factor 1

1

20

Small-scale

0.665

High

548706

VAV
Proto-oncogene vav

1

20

Small-scale

0.647

High

983483

PTN12
Tyrosine-protein phosphatase non-receptor type 12

1

20

Small-scale

0.647

High

1052822

FAK2
Protein-tyrosine kinase 2-beta

1

20

Small-scale

0.647

High

610402

CBL
E3 ubiquitin-protein ligase CBL

3

20

Small-scale

0.640

High

788964

MATK
Megakaryocyte-associated tyrosine-protein kinase

1

20

Small-scale

0.625

High

238408

JAK2
Tyrosine-protein kinase JAK2

1

20

Small-scale

0.618

High

383802

ERBB2
Receptor tyrosine-protein kinase erbB-2

1

20

Small-scale

0.618

High

411720

LCK
Tyrosine-protein kinase Lck

1

19

Small-scale

0.618

High

433760

LYN
Tyrosine-protein kinase Lyn

1

20

Small-scale

0.618

High

562561

IL7RA
Interleukin-7 receptor subunit alpha

1

2

Small-scale

0.618

High

601920

ERBB3
Receptor tyrosine-protein kinase erbB-3

1

20

Small-scale

0.618

High

616810

JAK1
Tyrosine-protein kinase JAK1

1

20

Small-scale

0.618

High

655366

P85A
Phosphatidylinositol 3-kinase regulatory subunit alpha

1

20

Small-scale

0.618

High

666110

SHC1
SHC-transforming protein 1

1

20

Small-scale

0.618

High

684033

1433S
14-3-3 protein sigma

1

20

High-throughput

0.618

High

776680

STAT3
Signal transducer and activator of transcription 3

1

20

Small-scale

0.618

High

796572

KSYK
Tyrosine-protein kinase SYK

1

20

Small-scale

0.618

High

854178

JAK3
Tyrosine-protein kinase JAK3

1

20

Small-scale

0.618

High

890662

PTEN
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

1

20

Small-scale

0.618

High

909560

1433E
14-3-3 protein epsilon

1

7

High-throughput

0.618

High

983374

DYN1
Dynamin-1

1

17

Small-scale

0.618

High

984496

KPCD
Protein kinase C delta type

1

20

Small-scale

0.618

High

1052824

CASL
Enhancer of filamentation 1

1

20

Small-scale

0.618

High

1052826

TRI67
Tripartite motif-containing protein 67

1

19

High-throughput

0.618

High

1052832

SH3K1
SH3 domain-containing kinase-binding protein 1

1

20

Small-scale

0.618

High

1052848

TLN1
Talin-1

1

20

Small-scale

0.618

High

1052849

M3K4
Mitogen-activated protein kinase kinase kinase 4

1

3

Small-scale

0.618

High

1052836

TRAF4
TNF receptor-associated factor 4

2

15

Small-scale

0.611

High

232881

PHLP1
PH domain leucine-rich repeat-containing protein phosphatase 1

1

20

High-throughput

0.590

High

1052843

CASS4
Cas scaffolding protein family member 4

1

20

High-throughput

0.590

High

1052845

KCC2A
Calcium/calmodulin-dependent protein kinase type II subunit alpha

1

9

High-throughput

0.590

High

1018893

NMDE1
Glutamate receptor ionotropic, NMDA 2A

2

14

Small-scale

0.584

High

1052830

PDC6I
Programmed cell death 6-interacting protein

2

18

Small-scale

0.584

High

238963

LPXN
Leupaxin

2

20

Small-scale

0.576

High

413910

GELS
Gelsolin

1

6

Small-scale

0.573

High

1052829

RBCC1
RB1-inducible coiled-coil protein 1

1

20

Small-scale

0.573

High

1052837

PITM3
Membrane-associated phosphatidylinositol transfer protein 3

1

3

Small-scale

0.573

High

967168

EWS
RNA-binding protein EWS

1

3

Small-scale

0.561

High

133090

PITM1
Membrane-associated phosphatidylinositol transfer protein 1

1

3

Small-scale

0.552

High

1052838

PITM2
Membrane-associated phosphatidylinositol transfer protein 2

1

3

Small-scale

0.552

High

1052844

MBD2
Methyl-CpG-binding domain protein 2

1

0

Small-scale

0.549

High

623930

THIL
Acetyl-CoA acetyltransferase, mitochondrial

1

2

High-throughput

0.536

High

1052839

ZFHX2
Zinc finger homeobox protein 2

1

4

High-throughput

0.536

High

394712

A4
Amyloid-beta precursor protein

1

13

High-throughput

0.515

High

396588

ITB3
Integrin beta-3

1

20

Small-scale

0.501

High

497014

TAU
Microtubule-associated protein tau

1

18

Small-scale

0.501

High

256888

NPHP4
Nephrocystin-4

1

2

Small-scale

0.479

High

396630

ITB2
Integrin beta-2

1

19

Small-scale

0.479

High

403881

ITB1
Integrin beta-1

1

20

Small-scale

0.479

High

431848

HS90A
Heat shock protein HSP 90-alpha

1

20

High-throughput

0.479

High

438167

HS90B
Heat shock protein HSP 90-beta

1

20

High-throughput

0.479

High

526503

GP1BB
Platelet glycoprotein Ib beta chain

1

8

Small-scale

0.479

High

558725

KCNA2
Potassium voltage-gated channel subfamily A member 2

1

10

Small-scale

0.479

High

808126

NEDD4
E3 ubiquitin-protein ligase NEDD4

1

20

Small-scale

0.479

High

872266

RD23B
UV excision repair protein RAD23 homolog B

1

1

High-throughput

0.479

High

1027605

CBLB
E3 ubiquitin-protein ligase CBL-B

1

20

Small-scale

0.479

High

1029206

GRM1
Metabotropic glutamate receptor 1

1

8

Small-scale

0.479

High

1052823

GNA13
Guanine nucleotide-binding protein subunit alpha-13

1

6

Small-scale

0.479

High

1052825

PEAK3
Protein PEAK3

1

5

Small-scale

0.479

High

1052834

NED4L
E3 ubiquitin-protein ligase NEDD4-like

1

20

Small-scale

0.479

High

1052835

MYD88
Myeloid differentiation primary response protein MyD88

1

7

Small-scale

0.479

High

1052841

ALG2
Alpha-1,3/1,6-mannosyltransferase ALG2

1

1

Small-scale

0.479

High

1052847

GIT1
ARF GTPase-activating protein GIT1

1

20

Small-scale

0.479

High

505396

GTR1
Solute carrier family 2, facilitated glucose transporter member 1

1

0

Small-scale

0.458

High

641408

PAX6
Paired box protein Pax-6

1

6

High-throughput

0.457

High

793313

MUC18
Cell surface glycoprotein MUC18

1

15

High-throughput

0.457

High

960790

CLH1
Clathrin heavy chain 1

1

5

High-throughput

0.457

High

1052833

CF418
Cilia- and flagella-associated protein 418

1

1

Small-scale

0.457

High

958678

2ABB
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform

1

1

High-throughput

0.445

High

1052828

DOCK8
Dedicator of cytokinesis protein 8

1

9

Small-scale

0.445

High

1052842

GPVI
Platelet glycoprotein VI

1

11

Small-scale

0.437

High

1052840

CPVL
Probable serine carboxypeptidase CPVL

1

0

High-throughput

0.279

Low

1052846

EXC6B
Exocyst complex component 6B

1

0

High-throughput

0.238

Low


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Last updated: 15 Jul 2024