HitPredict

Interactor 1: GRB2 (Q60631)
Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2)
Gene: GRB2

Interactor 2: DOK3 (Q9QZK7)
Docking protein 3 (Downstream of tyrosine kinase 3) (p62(dok)-like protein) (DOK-L)
Gene: DOK3

Species: Mus musculus

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	26548852
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005886 - plasma membrane GO:0007265 - Ras protein signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 217 Mm			1 444
+	Hs
		924665 GRB2_HUMAN (1-217): 6.92e-74: 224: 99.54		DOK3_HUMAN (1-444): 7.26e-164: 472: 77.70
+	Mm
		956520 GRB2_MOUSE (1-217): 3.97e-74: 225: 100.00		DOK1_MOUSE (4-400): 4.54e-122: 365: 30.92
+	Hs
		924816 GRB2_HUMAN (1-217): 6.92e-74: 224: 99.54		DOK1_HUMAN (4-400): 2.57e-119: 358: 33.58
+	Mm
		724599 GRB2_MOUSE (1-217): 3.97e-74: 225: 100.00		IRS1_MOUSE (9-366): 2.12e-86: 288: 14.67
+	Rn
		724631 GRB2_RAT (1-217): 6.92e-74: 224: 99.54		IRS1_RAT (9-366): 8.18e-87: 289: 14.67
+	Mm
		639441 LYN_MOUSE (3-202): 3.06e-38: 140: 27.49		DOK1_MOUSE (4-400): 4.54e-122: 365: 30.92
+	Hs
		724527 GRB2_HUMAN (1-217): 6.92e-74: 224: 99.54		IRS1_HUMAN (9-366): 3.64e-83: 279: 14.47
+	Hs
		151763 GRB2_HUMAN (1-217): 6.92e-74: 224: 99.54		IRS4_HUMAN (9-362): 3.84e-81: 274: 15.97
+	Mm
		250950 LYN_MOUSE (3-202): 3.06e-38: 140: 27.49		DOK2_MOUSE (5-419): 6.51e-108: 326: 30.77
+	Hs
		235035 LCK_HUMAN (3-202): 7.66e-38: 138: 28.91		DOK2_HUMAN (5-419): 2.4e-106: 323: 30.95
+	Hs
		924725 GRB2_HUMAN (1-217): 6.92e-74: 224: 99.54		FRS2_HUMAN (142-439): 6.12e-70: 231: 18.52
+	Mm
		1141149 GRB2_MOUSE (1-217): 3.97e-74: 225: 100.00		FRS2_MOUSE (142-438): 1.04e-68: 228: 18.58
+	Rn
		88884 GRB2_RAT (1-217): 6.92e-74: 224: 99.54		D4A244_RAT (142-438): 2.24e-66: 222: 18.89
+	Hs
		151689 LCK_HUMAN (3-202): 7.66e-38: 138: 28.91		IRS4_HUMAN (9-362): 3.84e-81: 274: 15.97
+	Mm
		946348 GRB2_MOUSE (1-217): 3.97e-74: 225: 100.00		IRS2_MOUSE (9-349): 1.83e-43: 165: 15.25
+	Hs
		924983 GRB2_HUMAN (1-217): 6.92e-74: 224: 99.54		IRS2_HUMAN (9-381): 1.32e-43: 165: 15.01
+	Rn
		94388 GRB2_RAT (1-217): 6.92e-74: 224: 99.54		F1MAL5_RAT (9-349): 3.68e-42: 161: 15.50
+	Hs
		411805 LCK_HUMAN (3-202): 7.66e-38: 138: 28.91		FRS2_HUMAN (142-439): 6.12e-70: 231: 18.52
+	Mm
		639440 LYN_MOUSE (3-202): 3.06e-38: 140: 27.49		IRS2_MOUSE (9-349): 1.83e-43: 165: 15.25
+	Dm
		993227 GRAP_DROME (1-215): 5.25e-62: 193: 61.86		IRS1_DROME (29-338): 1.25e-25: 112: 15.63