HitPredict

Interactor 1: IGF1R (Q60751)
Insulin-like growth factor 1 receptor (EC 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) (CD antigen CD221) [Cleaved into: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain]
Gene: IGF1R

Interactor 2: SNX9 (Q91VH2)
Sorting nexin-9
Gene: SNX9

Species: Mus musculus

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	12917015
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH3_1
Common GO terms	GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1373 Mm			1 595
+	Mm
		546277 INSR_MOUSE (4-1371): 0: 1256: 55.57		SNX9_MOUSE (1-595): 0: 563: 100.00
+	Hs
		240333 IGF1R_HUMAN (1-1373): 0: 1384: 95.34		SNX2_HUMAN (108-591): 2.81e-85: 276: 15.33
+	Hs
		435636 IGF1R_HUMAN (1-1373): 0: 1384: 95.34		SNX1_HUMAN (99-591): 2.73e-76: 253: 14.13
+	Hs
		435813 IGF1R_HUMAN (1-1373): 0: 1384: 95.34		SNX5_HUMAN (221-594): 7.57e-71: 235: 14.32
+	Hs
		435805 IGF1R_HUMAN (1-1373): 0: 1384: 95.34		SNX6_HUMAN (240-592): 7.05e-64: 217: 14.25
+	Rn
		71355 INSR_RAT (4-1371): 0: 1254: 54.78		B2RYP4_RAT (108-591): 2.11e-83: 272: 15.33
+	Hs
		240332 INSR_HUMAN (32-1371): 0: 1244: 56.20		SNX2_HUMAN (108-591): 2.81e-85: 276: 15.33
+	Hs
		411380 INSR_HUMAN (32-1371): 0: 1244: 56.20		SNX1_HUMAN (99-591): 2.73e-76: 253: 14.13
+	Hs
		411539 INSR_HUMAN (32-1371): 0: 1244: 56.20		SNX5_HUMAN (221-594): 7.57e-71: 235: 14.32
+	Rn
		102558 INSR_RAT (4-1371): 0: 1254: 54.78		G3V8U4_RAT (98-558): 9.84e-60: 209: 12.91
+	Hs
		411527 INSR_HUMAN (32-1371): 0: 1244: 56.20		SNX6_HUMAN (240-592): 7.05e-64: 217: 14.25
+	Hs
		307875 INSR_HUMAN (32-1371): 0: 1244: 56.20		SNX4_HUMAN (192-595): 8.56e-63: 215: 14.38
+	Hs
		339202 EGFR_HUMAN (330-1353): 8.74e-106: 366: 16.14		SNX9_HUMAN (1-595): 0: 543: 90.10
+	Hs
		240370 EPHA5_HUMAN (699-1289): 5.75e-166: 526: 23.12		SNX2_HUMAN (108-591): 2.81e-85: 276: 15.33
+	Hs
		872507 EPHA5_HUMAN (699-1289): 5.75e-166: 526: 23.12		SNX6_HUMAN (240-592): 7.05e-64: 217: 14.25
+	Hs
		240325 EGFR_HUMAN (330-1353): 8.74e-106: 366: 16.14		SNX2_HUMAN (108-591): 2.81e-85: 276: 15.33
+	Hs
		338393 EGFR_HUMAN (330-1353): 8.74e-106: 366: 16.14		SNX1_HUMAN (99-591): 2.73e-76: 253: 14.13
+	Hs
		339134 EGFR_HUMAN (330-1353): 8.74e-106: 366: 16.14		SNX6_HUMAN (240-592): 7.05e-64: 217: 14.25
+	Hs
		307874 EGFR_HUMAN (330-1353): 8.74e-106: 366: 16.14		SNX4_HUMAN (192-595): 8.56e-63: 215: 14.38
+	Hs
		234883 EGFR_HUMAN (330-1353): 8.74e-106: 366: 16.14		SNX3_HUMAN (246-355): 3.34e-14: 72.6: 22.84