HitPredict

Interactor 1: RIPK1 (Q60855)
Receptor-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (Cell death protein RIP) (Receptor-interacting protein 1) (RIP-1)
Gene: RIPK1

Interactor 2: FADD (Q61160)
FAS-associated death domain protein (FAS-associating death domain-containing protein) (Mediator of receptor induced toxicity)
Gene: FADD

Species: Mus musculus

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.95 1.00 0.978

The method score is based on:

Property Details
Experiments 18946037, 24144979, 27458237, 29891719, 29203883, 30209212, 30420664, 22037414, 26649818, 21368763, 24557836, 26555174, 19524513, 21052097
Identification Methods affinity chromatography technology, anti bait coimmunoprecipitation, tandem affinity purification
Interaction Type physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains Death~Death
Common GO terms GO:0005123 - death receptor binding
GO:0006915 - apoptotic process
GO:0008625 - extrinsic apoptotic signaling pathway via death domain receptors
GO:0031264 - death-inducing signaling complex
GO:0032757 - positive regulation of interleukin-8 production
and 12 others

more...
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024