Interactor 1: EZH2 (Q61188)
Histone-lysine N-methyltransferase EZH2 (EC 2.1.1.356) (ENX-1) (Enhancer of zeste homolog 2)
Gene: EZH2
Interactor 2: SUZ12 (Q80U70)
Polycomb protein Suz12 (Suppressor of zeste 12 protein homolog)
Gene: SUZ12
Species: Mus musculus
Source: mint
Category: Small-scale
Confidence: High
| Method score | Annotation score | Interaction score |
|---|---|---|
| 0.94 | 1.00 | 0.970 |
The method score is based on:
| Property | Details |
|---|---|
| Experiments | 25680957, 20064375, 22438827, 24040135, 20123894, 20064376, 23624935, 20075857, 24074865 |
| Identification Methods | proximity labelling technology, affinity chromatography technology, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation |
| Interaction Type | physical association, association |
The annotation score is based on:
| Property | Details |
|---|---|
| Interacting Pfam domains | PRC2_HTH_1~VEFS-Box, VEFS-Box~preSET_CXC, SET~VEFS-Box |
| Common GO terms | GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0001222 - transcription corepressor binding GO:0003682 - chromatin binding GO:0003723 - RNA binding and 12 others more... |
| Homologous interactions | 11 |
Homologous interactions
Color coding for hit scores 
|
|
|||||||||||||
| + | Hs |   |
|
|||||||||||
| + | Mm | |
|
|||||||||||
| + | Mm | |
|
|||||||||||
| + | Hs | |
|
|||||||||||
| + | Dm | |
|
|||||||||||
| + | Mm | |
|
|||||||||||
| + | Hs |  |
|
|||||||||||
| + | At | |
|
|||||||||||
| + | At | |
|
|||||||||||
| + | At | |
|
|||||||||||
| + | At | |
|
|||||||||||
Service provided by Combinatics, Japan
Last updated: 15 Jul 2024
