Protein: BRCA2
Breast cancer type 2 susceptibility protein (Fanconi anemia group D1 protein)

Gene: BRCA2
Organism: Homo sapiens
Interactions: 236
UniProt ID: P51587

Gene Ontology (top 5):
GO:0000152 - nuclear ubiquitin ligase complex
GO:0000722 - telomere maintenance via recombination
GO:0000724 - double-strand break repair via homologous recombination
GO:0000781 - chromosome, telomeric region
GO:0000800 - lateral element

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

847792

RAD51
DNA repair protein RAD51 homolog 1

55

10

Small-scale

0.997

High

847785

SEM1
26S proteasome complex subunit SEM1

11

0

Small-scale

0.929

High

207031

XRCC3
DNA repair protein XRCC3

5

10

Small-scale

0.912

High

847801

DMC1
Meiotic recombination protein DMC1/LIM15 homolog

3

10

Small-scale

0.898

High

847777

BRCA2
Breast cancer type 2 susceptibility protein

5

0

Small-scale

0.873

High

847841

PALB2
Partner and localizer of BRCA2

29

1

Small-scale

0.770

High

749248

BRCA1
Breast cancer type 1 susceptibility protein

12

3

Small-scale

0.759

High

847889

FACD2
Fanconi anemia group D2 protein

8

2

Small-scale

0.753

High

206272

RA51C
DNA repair protein RAD51 homolog 3

1

10

Small-scale

0.730

High

847779

PLK1
Serine/threonine-protein kinase PLK1

6

0

Small-scale

0.714

High

847912

HM20B
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1-related

4

2

Small-scale

0.711

High

386344

P53
Cellular tumor antigen p53

6

0

Small-scale

0.707

High

622407

CCND1
G1/S-specific cyclin-D1

3

3

Small-scale

0.676

High

847923

HSPB8
Heat shock protein beta-8

3

1

High-throughput

0.675

High

174374

FANCG
Fanconi anemia group G protein

4

0

Small-scale

0.669

High

847880

BARD1
BRCA1-associated RING domain protein 1

4

0

Small-scale

0.667

High

847919

MO4L1
Mortality factor 4-like protein 1

3

3

Small-scale

0.656

High

625249

CDK2
Cyclin-dependent kinase 2

3

1

Small-scale

0.655

High

847783

MLF1
Myeloid leukemia factor 1

3

0

High-throughput

0.638

High

847895

DSN1
Kinetochore-associated protein DSN1 homolog

3

0

High-throughput

0.638

High

847908

NSE4A
Non-structural maintenance of chromosomes element 4 homolog A

3

0

High-throughput

0.638

High

847865

KAT2B
Histone acetyltransferase KAT2B

3

0

Small-scale

0.636

High

847778

UBP11
Ubiquitin carboxyl-terminal hydrolase 11

2

1

Small-scale

0.629

High

847805

MO4L2
Mortality factor 4-like protein 2

2

3

High-throughput

0.628

High

847839

SNX32
Sorting nexin-32

2

1

High-throughput

0.628

High

236898

BUB1B
Mitotic checkpoint serine/threonine-protein kinase BUB1 beta

3

0

Small-scale

0.625

High

847903

PDS5B
Sister chromatid cohesion protein PDS5 homolog B

2

0

Small-scale

0.620

High

650714

RFA1
Replication protein A 70 kDa DNA-binding subunit

2

0

Small-scale

0.612

High

331235

CHK2
Serine/threonine-protein kinase Chk2

3

0

Small-scale

0.608

High

847916

BCCIP
BRCA2 and CDKN1A-interacting protein

2

0

Small-scale

0.605

High

314022

BAG4
BAG family molecular chaperone regulator 4

2

0

High-throughput

0.602

High

847825

CNDH2
Condensin-2 complex subunit H2

2

0

High-throughput

0.602

High

847863

PPM1E
Protein phosphatase 1E

2

0

High-throughput

0.602

High

847885

AASD1
Alanyl-tRNA editing protein Aarsd1

2

0

High-throughput

0.602

High

847902

SPNXA
Sperm protein associated with the nucleus on the X chromosome A

2

0

High-throughput

0.602

High

847936

LMBL1
Lethal(3)malignant brain tumor-like protein 1

2

0

High-throughput

0.602

High

805514

BRCC3
Lys-63-specific deubiquitinase BRCC36

2

0

Small-scale

0.595

High

847793

TP53B
TP53-binding protein 1

2

1

Small-scale

0.595

High

847828

DPPA3
Developmental pluripotency-associated protein 3

2

0

Small-scale

0.585

High

847798

KEAP1
Kelch-like ECH-associated protein 1

2

1

Small-scale

0.584

High

847844

SLX4
Structure-specific endonuclease subunit SLX4

2

1

High-throughput

0.584

High

847836

EMSY
BRCA2-interacting transcriptional repressor EMSY

1

1

Small-scale

0.573

High

847920

LIMD1
LIM domain-containing protein 1

1

1

Small-scale

0.573

High

847931

POLH
DNA polymerase eta

1

0

Small-scale

0.571

High

555360

H2AX
Histone H2AX

2

0

Small-scale

0.569

High

552273

RFA2
Replication protein A 32 kDa subunit

2

0

Small-scale

0.563

High

63204

WTIP
Wilms tumor protein 1-interacting protein

1

1

Small-scale

0.561

High

198232

DC1L2
Cytoplasmic dynein 1 light intermediate chain 2

1

1

Small-scale

0.561

High

847788

CCNA1
Cyclin-A1

1

2

Small-scale

0.561

High

847789

SMAD3
Mothers against decapentaplegic homolog 3

1

1

Small-scale

0.561

High

847940

DC1L1
Cytoplasmic dynein 1 light intermediate chain 1

1

1

Small-scale

0.561

High

598018

FLNA
Filamin-A

1

0

Small-scale

0.549

High

275258

RNH2A
Ribonuclease H2 subunit A

1

0

Small-scale

0.537

High

659912

ERCC5
DNA excision repair protein ERCC-5

1

0

Small-scale

0.537

High

847806

PLEC
Plectin

1

0

Small-scale

0.537

High

847925

UBP21
Ubiquitin carboxyl-terminal hydrolase 21

1

0

Small-scale

0.537

High

252972

HSF2B
Heat shock factor 2-binding protein

1

1

High-throughput

0.536

High

358732

CRYAA
Alpha-crystallin A chain

1

1

High-throughput

0.536

High

431668

HS90A
Heat shock protein HSP 90-alpha

1

2

High-throughput

0.536

High

438008

HS90B
Heat shock protein HSP 90-beta

1

2

High-throughput

0.536

High

796059

MAGA9
Melanoma-associated antigen 9

1

1

High-throughput

0.536

High

847810

MK06
Mitogen-activated protein kinase 6

1

1

High-throughput

0.536

High

847848

K2C78
Keratin, type II cytoskeletal 78

1

1

High-throughput

0.536

High

847927

SNX6
Sorting nexin-6

1

1

High-throughput

0.536

High

847917

RBL2A
Rab-like protein 2A

2

1

High-throughput

0.533

High

847892

MLP3B
Microtubule-associated proteins 1A/1B light chain 3B

1

0

High-throughput

0.513

High

149840

RFXK
DNA-binding protein RFXANK

1

0

High-throughput

0.513

High

224366

RAD21
Double-strand-break repair protein rad21 homolog

1

0

Small-scale

0.513

High

264192

CDC45
Cell division control protein 45 homolog

1

0

Small-scale

0.513

High

280962

KRT38
Keratin, type I cuticular Ha8

1

0

High-throughput

0.513

High

517138

PCNA
Proliferating cell nuclear antigen

1

0

Small-scale

0.513

High

714142

HSP74
Heat shock 70 kDa protein 4

1

0

High-throughput

0.513

High

729053

K22E
Keratin, type II cytoskeletal 2 epidermal

1

0

High-throughput

0.513

High

847800

SRC8
Src substrate cortactin

1

0

High-throughput

0.513

High

847807

TEBP
Prostaglandin E synthase 3

1

0

High-throughput

0.513

High

847811

UPP1
Uridine phosphorylase 1

1

0

High-throughput

0.513

High

847813

CF184
Cilia- and flagella-associated protein 184

1

0

High-throughput

0.513

High

847817

EFMT2
EEF1A lysine methyltransferase 2

1

0

High-throughput

0.513

High

847868

TRI52
E3 ubiquitin-protein ligase TRIM52

1

0

High-throughput

0.513

High

847879

DNJC7
DnaJ homolog subfamily C member 7

1

0

High-throughput

0.513

High

847884

NAA11
N-alpha-acetyltransferase 11

1

0

High-throughput

0.513

High

847890

DUS16
Dual specificity protein phosphatase 16

1

0

High-throughput

0.513

High

847898

EGLN3
Prolyl hydroxylase EGLN3

1

0

High-throughput

0.513

High

847907

BABA2
BRISC and BRCA1-A complex member 2

1

0

Small-scale

0.513

High

847929

SMC3
Structural maintenance of chromosomes protein 3

1

0

Small-scale

0.513

High

847935

CRYL1
Lambda-crystallin homolog

1

0

High-throughput

0.513

High

162524

XPO1
Exportin-1

1

0

Small-scale

0.505

High

590152

CCNA2
Cyclin-A2

1

2

Small-scale

0.501

High

847794

ATM
Serine-protein kinase ATM

1

2

Small-scale

0.501

High

582148

NUCL
Nucleolin

1

0

High-throughput

0.493

High

847782

RD23A
UV excision repair protein RAD23 homolog A

1

0

Small-scale

0.493

High

847814

KLH40
Kelch-like protein 40

1

2

High-throughput

0.489

High

847939

MAGD1
Melanoma-associated antigen D1

1

1

Small-scale

0.481

High

154153

CHK1
Serine/threonine-protein kinase Chk1

1

0

Small-scale

0.480

High

337402

ABL1
Tyrosine-protein kinase ABL1

1

1

High-throughput

0.479

High

412094

FYN
Tyrosine-protein kinase Fyn

1

1

High-throughput

0.479

High

538162

ENPL
Endoplasmin

1

2

Small-scale

0.479

High

538499

CCNB1
G2/mitotic-specific cyclin-B1

1

2

Small-scale

0.479

High

847780

PMS1
PMS1 protein homolog 1

1

1

High-throughput

0.479

High

847781

PMS2
Mismatch repair endonuclease PMS2

1

1

High-throughput

0.479

High

847786

GRB2
Growth factor receptor-bound protein 2

1

2

High-throughput

0.479

High

847791

TLE3
Transducin-like enhancer protein 3

1

1

High-throughput

0.479

High

847799

DYHC1
Cytoplasmic dynein 1 heavy chain 1

1

1

Small-scale

0.479

High

847802

MDC1
Mediator of DNA damage checkpoint protein 1

1

1

High-throughput

0.479

High

847809

SMAD2
Mothers against decapentaplegic homolog 2

1

1

Small-scale

0.479

High

847832

RUFY3
Protein RUFY3

1

1

Small-scale

0.479

High

847843

SMC5
Structural maintenance of chromosomes protein 5

1

1

High-throughput

0.479

High

847850

MIER2
Mesoderm induction early response protein 2

1

2

High-throughput

0.479

High

847851

NIN
Ninein

1

3

High-throughput

0.479

High

847859

NUP43
Nucleoporin Nup43

1

1

High-throughput

0.479

High

847861

CT55
Cancer/testis antigen 55

1

1

Small-scale

0.479

High

847881

TEP1
Telomerase protein component 1

1

1

Small-scale

0.479

High

847882

LZTS2
Leucine zipper putative tumor suppressor 2

1

2

High-throughput

0.479

High

847926

RCOR1
REST corepressor 1

1

2

High-throughput

0.479

High

847934

NINL
Ninein-like protein

1

2

High-throughput

0.479

High

847937

TRRAP
Transformation/transcription domain-associated protein

1

2

High-throughput

0.479

High

847905

FANCI
Fanconi anemia group I protein

1

0

Small-scale

0.460

High

154012

TERT
Telomerase reverse transcriptase

1

0

Small-scale

0.458

High

181688

DDX3Y
ATP-dependent RNA helicase DDX3Y

1

0

Small-scale

0.458

High

198578

PSMD3
26S proteasome non-ATPase regulatory subunit 3

1

0

Small-scale

0.458

High

232059

KDM1A
Lysine-specific histone demethylase 1A

1

0

High-throughput

0.458

High

254458

ROCK2
Rho-associated protein kinase 2

1

0

Small-scale

0.458

High

266472

SUPT3
Transcription initiation protein SPT3 homolog

1

0

Small-scale

0.458

High

309292

KIF4A
Chromosome-associated kinesin KIF4A

1

0

Small-scale

0.458

High

318589

EYA4
Eyes absent homolog 4

1

0

High-throughput

0.458

High

373364

CATA
Catalase

1

0

Small-scale

0.458

High

418059

NPM
Nucleophosmin

1

0

Small-scale

0.458

High

435015

SP1
Transcription factor Sp1

1

0

Small-scale

0.458

High

506225

PYGM
Glycogen phosphorylase, muscle form

1

0

Small-scale

0.458

High

560388

MGMT
Methylated-DNA--protein-cysteine methyltransferase

1

0

Small-scale

0.458

High

569418

CEBPB
CCAAT/enhancer-binding protein beta

1

0

High-throughput

0.458

High

624817

RPB1
DNA-directed RNA polymerase II subunit RPB1

1

0

Small-scale

0.458

High

652786

APEX1
DNA repair nuclease/redox regulator APEX1

1

0

High-throughput

0.458

High

720011

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.458

High

786593

STA5A
Signal transducer and activator of transcription 5A

1

0

Small-scale

0.458

High

847784

BPIB4
BPI fold-containing family B member 4

1

0

Small-scale

0.458

High

847787

PP2AA
Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform

1

0

Small-scale

0.458

High

847790

KMT2A
Histone-lysine N-methyltransferase 2A

1

0

High-throughput

0.458

High

847796

HDAC1
Histone deacetylase 1

1

0

High-throughput

0.458

High

847804

PSMD6
26S proteasome non-ATPase regulatory subunit 6

1

0

Small-scale

0.458

High

847808

PTPA
Serine/threonine-protein phosphatase 2A activator

1

0

Small-scale

0.458

High

847812

CL16A
Protein CLEC16A

1

0

High-throughput

0.458

High

847815

C19L2
CWF19-like protein 2

1

0

Small-scale

0.458

High

847818

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

0

Small-scale

0.458

High

847820

CELF3
CUGBP Elav-like family member 3

1

0

Small-scale

0.458

High

847822

DCA12
DDB1- and CUL4-associated factor 12

1

0

High-throughput

0.458

High

847823

UT14C
U3 small nucleolar RNA-associated protein 14 homolog C

1

0

Small-scale

0.458

High

847824

CP135
Centrosomal protein of 135 kDa

1

0

High-throughput

0.458

High

847827

CF299
Cilia- and flagella-associated protein 299

1

0

Small-scale

0.458

High

847831

BNC2
Zinc finger protein basonuclin-2

1

0

Small-scale

0.458

High

847834

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

0

High-throughput

0.458

High

847835

MYH14
Myosin-14

1

0

Small-scale

0.458

High

847837

DPOLN
DNA polymerase nu

1

0

Small-scale

0.458

High

847838

SHLD2
Shieldin complex subunit 2

1

0

Small-scale

0.458

High

847840

DGKH
Diacylglycerol kinase eta

1

0

Small-scale

0.458

High

847842

ASXL1
Polycomb group protein ASXL1

1

0

High-throughput

0.458

High

847846

RN168
E3 ubiquitin-protein ligase RNF168

1

0

Small-scale

0.458

High

847847

SYCP3
Synaptonemal complex protein 3

1

0

Small-scale

0.458

High

847857

FXL13
F-box and leucine-rich repeat protein 13

1

0

Small-scale

0.458

High

847858

MCPH1
Microcephalin

1

0

Small-scale

0.458

High

847866

RAD50
DNA repair protein RAD50

1

0

Small-scale

0.458

High

847869

PF21A
PHD finger protein 21A

1

0

High-throughput

0.458

High

847870

ZN707
Zinc finger protein 707

1

0

Small-scale

0.458

High

847871

SNR40
U5 small nuclear ribonucleoprotein 40 kDa protein

1

0

High-throughput

0.458

High

847872

DTBP1
Dysbindin

1

0

High-throughput

0.458

High

847873

ZN503
Zinc finger protein 503

1

0

Small-scale

0.458

High

847875

AURKB
Aurora kinase B

1

0

Small-scale

0.458

High

847876

NSL1
Kinetochore-associated protein NSL1 homolog

1

0

High-throughput

0.458

High

847886

IER2
Immediate early response gene 2 protein

1

0

High-throughput

0.458

High

847888

FANCJ
Fanconi anemia group J protein

1

0

Small-scale

0.458

High

847893

RPA49
DNA-directed RNA polymerase I subunit RPA49

1

0

High-throughput

0.458

High

847896

CHM4B
Charged multivesicular body protein 4b

1

0

Small-scale

0.458

High

847899

FANCE
Fanconi anemia group E protein

1

0

Small-scale

0.458

High

847909

ETAA1
Ewing's tumor-associated antigen 1

1

0

Small-scale

0.458

High

847910

TE2IP
Telomeric repeat-binding factor 2-interacting protein 1

1

0

High-throughput

0.458

High

847914

MDFIC
MyoD family inhibitor domain-containing protein

1

0

Small-scale

0.458

High

847918

ASH2L
Set1/Ash2 histone methyltransferase complex subunit ASH2

1

0

High-throughput

0.458

High

847921

EI2BD
Translation initiation factor eIF2B subunit delta

1

0

Small-scale

0.458

High

847922

ANC2
Anaphase-promoting complex subunit 2

1

0

High-throughput

0.458

High

847924

VPS28
Vacuolar protein sorting-associated protein 28 homolog

1

0

High-throughput

0.458

High

847928

TTF2
Transcription termination factor 2

1

0

Small-scale

0.458

High

847930

MTMR6
Myotubularin-related protein 6

1

0

Small-scale

0.458

High

847932

ASF1A
Histone chaperone ASF1A

1

0

High-throughput

0.458

High

847933

CARD8
Caspase recruitment domain-containing protein 8

1

0

High-throughput

0.458

High

847938

SHAN1
SH3 and multiple ankyrin repeat domains protein 1

1

0

Small-scale

0.458

High

295968

MTA2
Metastasis-associated protein MTA2

1

2

Small-scale

0.445

High

817812

SOX2
Transcription factor SOX-2

1

1

High-throughput

0.445

High

146713

NCKP5
Nck-associated protein 5

1

1

Small-scale

0.437

High

847849

CFA52
Cilia- and flagella-associated protein 52

1

1

Small-scale

0.437

High

847901

STRN4
Striatin-4

1

1

Small-scale

0.437

High

847911

DYH9
Dynein axonemal heavy chain 9

1

1

Small-scale

0.437

High

847906

TRM1
tRNA

1

0

High-throughput

0.426

High

847795

ATR
Serine/threonine-protein kinase ATR

1

2

Small-scale

0.408

High

81863

B7ZBD5
RAB, member of RAS oncogene family like 2A

1

1

High-throughput

0.407

High

808051

NEDD4
E3 ubiquitin-protein ligase NEDD4

1

0

Small-scale

0.391

High

847819

CF141
Uncharacterized protein C6orf141

2

0

High-throughput

0.328

High

847856

SAXO5
Stabilizer of axonemal microtubules 5

2

0

High-throughput

0.328

High

847867

CNKR1
Connector enhancer of kinase suppressor of ras 1

2

0

High-throughput

0.328

High

847816

T10IP
Testis-specific protein 10-interacting protein

1

0

High-throughput

0.279

Low

847854

PRLD2
PRELI domain-containing protein 2

1

0

High-throughput

0.279

Low

847874

BORC8
BLOC-1-related complex subunit 8

1

0

High-throughput

0.279

Low

847878

TCPQM
T-complex protein 1 subunit theta-like 2

1

0

High-throughput

0.279

Low

839551

SERPH
Serpin H1

1

0

Small-scale

0.261

Low

847904

UQCC1
Ubiquinol-cytochrome c reductase complex assembly factor 1

1

0

Small-scale

0.261

Low

330374

PPR17
Protein phosphatase 1 regulatory subunit 17

1

0

Small-scale

0.249

Low

336811

FA8
Coagulation factor VIII

1

0

Small-scale

0.249

Low

441713

CFAH
Complement factor H

1

0

Small-scale

0.249

Low

448907

MMP10
Stromelysin-2

1

0

Small-scale

0.249

Low

517906

COBA1

1

0

Small-scale

0.249

Low

596340

ASPG
N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase

1

0

Small-scale

0.249

Low

723019

OPRM
Mu-type opioid receptor

1

0

Small-scale

0.249

Low

847797

TRI29
Tripartite motif-containing protein 29

1

0

Small-scale

0.249

Low

847803

MF13A
Transmembrane protein 180

1

0

Small-scale

0.249

Low

847821

DCST2
DC-STAMP domain-containing protein 2

1

0

Small-scale

0.249

Low

847826

GP179
Probable G-protein coupled receptor 179

1

0

Small-scale

0.249

Low

847829

ZY11A
Protein zyg-11 homolog A

1

0

Small-scale

0.249

Low

847830

SYNE3
Nesprin-3

1

0

High-throughput

0.249

Low

847833

MOT14
Monocarboxylate transporter 14

1

0

Small-scale

0.249

Low

847852

CCD24
Coiled-coil domain-containing protein 24

1

0

Small-scale

0.249

Low

847853

TO6BL
Type 2 DNA topoisomerase 6 subunit B-like

1

0

Small-scale

0.249

Low

847860

CLHC1
Clathrin heavy chain linker domain-containing protein 1

1

0

Small-scale

0.249

Low

847862

DYDC1
DPY30 domain-containing protein 1

1

0

Small-scale

0.249

Low

847864

FIG4
Polyphosphoinositide phosphatase

1

0

Small-scale

0.249

Low

847883

CAB45
45 kDa calcium-binding protein

1

0

High-throughput

0.249

Low

847887

CABL2
CDK5 and ABL1 enzyme substrate 2

1

0

Small-scale

0.249

Low

847891

GRB1L
GREB1-like protein

1

0

Small-scale

0.249

Low

847894

IPYR2
Inorganic pyrophosphatase 2, mitochondrial

1

0

Small-scale

0.249

Low

847897

FZD8
Frizzled-8

1

0

Small-scale

0.249

Low

847900

SO1B3
Solute carrier organic anion transporter family member 1B3

1

0

Small-scale

0.249

Low

847915

RELCH
RAB11-binding protein RELCH

1

0

Small-scale

0.249

Low

478735

PNM6A
Paraneoplastic antigen-like protein 6A

1

0

High-throughput

0.232

Low

847845

KATL2
Katanin p60 ATPase-containing subunit A-like 2

1

0

High-throughput

0.232

Low

847855

GG6L2
Golgin subfamily A member 6-like protein 2

1

0

High-throughput

0.232

Low

847877

NEUL4
Neuralized-like protein 4

1

0

High-throughput

0.232

Low

847913

PP4RL
Putative serine/threonine-protein phosphatase 4 regulatory subunit 1-like

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024