HitPredict

Interactor 1: SOS1 (Q62245)
Son of sevenless homolog 1 (SOS-1) (mSOS-1)
Gene: SOS1

Interactor 2: SPY2 (Q9QXV8)
Protein sprouty homolog 2 (Spry-2)
Gene: Spry2

Species: Mus musculus

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	11585837, 16339969
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0008543 - fibroblast growth factor receptor signaling pathway GO:0045742 - positive regulation of epidermal growth factor receptor signaling pathway
Homologous interactions	5

Homologous interactions

Color coding for hit scores

	1 1319 Mm			1 315
+	Hs
		208131 SOS1_HUMAN (1-1319): 0: 1011: 94.67		SPY2_HUMAN (1-315): 1.09e-132: 381: 95.89
+	Mm
		1143703 SOS1_MOUSE (1-1319): 0: 1018: 100.00		SPY4_MOUSE (3-309): 1.57e-99: 296: 41.03
+	Mm
		1143702 SOS1_MOUSE (1-1319): 0: 1018: 100.00		SPY1_MOUSE (1-315): 8.09e-98: 292: 49.38
+	Mm
		1113313 SOS1_MOUSE (1-1319): 0: 1018: 100.00		SPRY3_MOUSE (39-313): 2.58e-82: 252: 44.21
+	Hs
		208418 SOS1_HUMAN (1-1319): 0: 1011: 94.67		SPY3_HUMAN (39-313): 8.49e-85: 258: 44.56