Protein: SIA8D
CMP-N-acetylneuraminate-poly-alpha-2,8-sialyltransferase (EC 2.4.3.-) (Alpha-2,8-sialyltransferase 8D) (Polysialyltransferase) (Polysialyltransferase-1) (Sialyltransferase 8D) (SIAT8-D) (Sialyltransferase St8Sia IV) (ST8SiaIV)

Gene: SIA8D, ST8SIA4
Organism: Homo sapiens
Interactions: 86
UniProt ID: Q92187

Gene Ontology (top 5):
GO:0000139 - Golgi membrane
GO:0001574 - ganglioside biosynthetic process
GO:0003828 - alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity
GO:0005576 - extracellular region
GO:0005794 - Golgi apparatus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1362515

SIA8B
Alpha-2,8-sialyltransferase 8B

1

2

High-throughput

0.691

High

249056

NRP2
Neuropilin-2

2

2

High-throughput

0.628

High

274905

LRP5
Low-density lipoprotein receptor-related protein 5

2

5

High-throughput

0.628

High

520946

HLAC
HLA class I histocompatibility antigen, C alpha chain

2

9

High-throughput

0.628

High

931974

EPHB4
Ephrin type-B receptor 4

2

1

High-throughput

0.628

High

1008443

ADA17
Disintegrin and metalloproteinase domain-containing protein 17

2

2

High-throughput

0.628

High

1143764

PON2
Serum paraoxonase/arylesterase 2

2

5

High-throughput

0.628

High

1175821

T132A
Transmembrane protein 132A

2

1

High-throughput

0.628

High

1243280

GLT18
Polypeptide N-acetylgalactosaminyltransferase 18

2

4

High-throughput

0.628

High

1316111

K319L
Dyslexia-associated protein KIAA0319-like protein

2

1

High-throughput

0.628

High

1360633

AGRV1
Adhesion G-protein coupled receptor V1

2

5

High-throughput

0.628

High

1362519

HMR1
Major histocompatibility complex class I-related protein 1

2

13

High-throughput

0.628

High

1362523

CSTN3
Calsyntenin-3

2

8

High-throughput

0.628

High

1362526

CNTP3
Contactin-associated protein-like 3

2

1

High-throughput

0.628

High

1362527

KPCD2
Serine/threonine-protein kinase D2

2

2

High-throughput

0.628

High

1116268

PTC1
Protein patched homolog 1

3

4

High-throughput

0.609

High

337277

ATS2
A disintegrin and metalloproteinase with thrombospondin motifs 2

2

0

High-throughput

0.602

High

880048

DNSL1
Deoxyribonuclease-1-like 1

2

0

High-throughput

0.602

High

997060

TBA4A
Tubulin alpha-4A chain

2

0

High-throughput

0.602

High

1028107

B4GN1
Beta-1,4 N-acetylgalactosaminyltransferase 1

2

0

High-throughput

0.602

High

1041640

TGBR3
Transforming growth factor beta receptor type 3

2

0

High-throughput

0.602

High

1362538

BACE2
Beta-secretase 2

2

0

High-throughput

0.602

High

175404

PLXB2
Plexin-B2

2

6

High-throughput

0.574

High

269695

PLXA2
Plexin-A2

2

5

High-throughput

0.574

High

448055

ITAV
Integrin alpha-V

2

4

High-throughput

0.574

High

565432

ITA4
Integrin alpha-4

2

4

High-throughput

0.574

High

612101

ITB5
Integrin beta-5

2

3

High-throughput

0.574

High

977780

ACTA
Actin, aortic smooth muscle

2

1

High-throughput

0.574

High

1101393

SG2A2
Mammaglobin-A

2

4

High-throughput

0.574

High

1116733

ITA7
Integrin alpha-7 [Cleaved into: Integrin alpha-7 heavy chain; Integrin alpha-7 light chain; Integrin alpha-7 70 kDa form]

2

4

High-throughput

0.574

High

1127586

FAT1
Protocadherin Fat 1

2

2

High-throughput

0.574

High

1211491

FREM2
FRAS1-related extracellular matrix protein 2

2

5

High-throughput

0.574

High

1248515

SUSD1
Sushi domain-containing protein 1

2

2

High-throughput

0.574

High

1288095

OAF
Out at first protein homolog

2

1

High-throughput

0.574

High

1294367

FRAS1
Extracellular matrix organizing protein FRAS1

2

4

High-throughput

0.574

High

1339602

NLGN2
Neuroligin-2

2

1

High-throughput

0.574

High

1362522

RUFY1
RUN and FYVE domain-containing protein 1

2

2

High-throughput

0.574

High

1362528

CELR2
Cadherin EGF LAG seven-pass G-type receptor 2

2

2

High-throughput

0.574

High

1362531

MRC2
C-type mannose receptor 2

2

1

High-throughput

0.574

High

1362535

PLXA1
Plexin-A1

2

5

High-throughput

0.574

High

287596

LRP6
Low-density lipoprotein receptor-related protein 6

1

5

High-throughput

0.536

High

363643

EGFR
Epidermal growth factor receptor

1

1

High-throughput

0.536

High

593456

PGFRA
Platelet-derived growth factor receptor alpha

1

2

High-throughput

0.536

High

719729

HLAF
HLA class I histocompatibility antigen, alpha chain F

1

9

High-throughput

0.536

High

914869

NDST2
Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 2

1

1

High-throughput

0.536

High

922834

ITA8
Integrin alpha-8 [Cleaved into: Integrin alpha-8 heavy chain; Integrin alpha-8 light chain]

1

4

High-throughput

0.536

High

1251501

CD109
CD109 antigen

1

4

High-throughput

0.536

High

1362529

IMPA3
Golgi-resident adenosine 3',5'-bisphosphate 3'-phosphatase

1

1

High-throughput

0.536

High

1362536

FBX2
F-box only protein 2

1

3

High-throughput

0.536

High

60734

F234B
Protein FAM234B

1

0

High-throughput

0.513

High

665123

COT2
COUP transcription factor 2

1

0

High-throughput

0.513

High

898386

BCAM
Basal cell adhesion molecule

1

0

High-throughput

0.513

High

1089117

HYAL2
Hyaluronidase-2

1

0

High-throughput

0.513

High

1315968

NRSN1
Neurensin-1

1

0

High-throughput

0.513

High

1325545

LARG2
Xylosyl- and glucuronyltransferase LARGE2

1

0

High-throughput

0.513

High

1362530

FPRP
Prostaglandin F2 receptor negative regulator

1

0

High-throughput

0.513

High

164404

NRP1
Neuropilin-1

1

2

High-throughput

0.489

High

706240

S10A2
Protein S100-A2

1

5

High-throughput

0.489

High

882798

EFTU
Elongation factor Tu, mitochondrial

1

1

High-throughput

0.489

High

907924

PLXA3
Plexin-A3

1

6

High-throughput

0.489

High

1143647

NOMO1
BOS complex subunit NOMO1

1

2

High-throughput

0.489

High

1144643

PTPRK
Receptor-type tyrosine-protein phosphatase kappa

1

1

High-throughput

0.489

High

1291957

LRP11
Low-density lipoprotein receptor-related protein 11

1

2

High-throughput

0.489

High

1292119

ANR46
Ankyrin repeat domain-containing protein 46

1

3

High-throughput

0.489

High

1292538

AMGO1
Amphoterin-induced protein 1

1

3

High-throughput

0.489

High

1309791

IPRI
Inositol 1,4,5-trisphosphate receptor-interacting protein

1

1

High-throughput

0.489

High

1362517

PTPRU
Receptor-type tyrosine-protein phosphatase U

1

1

High-throughput

0.489

High

1362533

SUN2
SUN domain-containing protein 2

1

1

High-throughput

0.489

High

458705

SAP
Prosaposin

1

0

High-throughput

0.458

High

369267

ANT3
Antithrombin-III

1

3

High-throughput

0.445

High

1362537

PCDBB
Protocadherin beta-11

1

0

High-throughput

0.426

High

876712

HSP13
Heat shock 70 kDa protein 13

1

1

High-throughput

0.407

High

1052372

RN5A
2-5A-dependent ribonuclease

2

0

High-throughput

0.328

High

1108640

TBB3
Tubulin beta-3 chain

2

0

High-throughput

0.328

High

1214113

DIK1A
Divergent protein kinase domain 1A

2

0

High-throughput

0.328

High

1218158

CAHD1
VWFA and cache domain-containing protein 1

2

0

High-throughput

0.328

High

1362518

SEM4D
Semaphorin-4D

2

0

High-throughput

0.328

High

1362520

TECT2
Tectonic-2

2

0

High-throughput

0.328

High

1362532

STK39
STE20/SPS1-related proline-alanine-rich protein kinase

2

0

High-throughput

0.328

High

1362534

LCAP
Leucyl-cystinyl aminopeptidase

2

0

High-throughput

0.328

High

934256

BI1
Bax inhibitor 1

1

0

High-throughput

0.279

Low

1204882

MKS3
Meckelin

1

0

High-throughput

0.279

Low

1362521

LRIG1
Leucine-rich repeats and immunoglobulin-like domains protein 1

1

0

High-throughput

0.279

Low

1362524

ZNG1A
Zinc-regulated GTPase metalloprotein activator 1A

1

0

High-throughput

0.279

Low

1362525

C1QT7
Complement C1q tumor necrosis factor-related protein 7

1

0

High-throughput

0.279

Low

599517

FAAA
Fumarylacetoacetase

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025