HitPredict

Interactor 1: TGFR2 (Q62312)
TGF-beta receptor type-2 (TGFR-2) (EC 2.7.11.30) (TGF-beta type II receptor) (Transforming growth factor-beta receptor type II) (TGF-beta receptor type II) (TbetaR-II)
Gene: Tgfbr2

Interactor 2: TGFR1 (Q64729)
TGF-beta receptor type-1 (TGFR-1) (EC 2.7.11.30) (ESK2) (Transforming growth factor-beta receptor type I) (TGF-beta receptor type I) (TbetaR-I)
Gene: Tgfbr1

Species: Mus musculus

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.76 1.00 0.873

The method score is based on:

Property Details
Experiments 24319055, 12070302, 21518866, 18337748
Identification Methods affinity chromatography technology, anti bait coimmunoprecipitation
Interaction Type physical association

The annotation score is based on:

Property Details
Interacting Pfam domains Activin_recp~ecTbetaR2, PK_Tyr_Ser-Thr~Pkinase, PK_Tyr_Ser-Thr~TGF_beta_GS
Common GO terms GO:0001701 - in utero embryonic development
GO:0002088 - lens development in camera-type eye
GO:0005024 - transforming growth factor beta receptor activity
GO:0005524 - ATP binding
GO:0005886 - plasma membrane
and 19 others

more...
Homologous interactions 18

Homologous interactions

Color coding for hit scores

1 567
Mm

1 503
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Last updated: 15 Jul 2024