Protein: PON1
Serum paraoxonase/arylesterase 1 (PON 1) (EC 3.1.1.2) (EC 3.1.1.81) (EC 3.1.8.1) (Aromatic esterase 1) (A-esterase 1) (K-45) (Serum aryldialkylphosphatase 1)

Gene: PON1
Organism: Homo sapiens
Interactions: 22
UniProt ID: P27169

Gene Ontology (top 5):
GO:0004063 - aryldialkylphosphatase activity
GO:0004064 - arylesterase activity
GO:0005509 - calcium ion binding
GO:0005543 - phospholipid binding
GO:0005576 - extracellular region

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

690584

PON3
Serum paraoxonase/lactonase 3

2

1

High-throughput

0.628

High

690587

MICU2
Calcium uptake protein 2, mitochondrial

2

0

High-throughput

0.602

High

690583

NFYC
Nuclear transcription factor Y subunit gamma

2

1

High-throughput

0.574

High

690589

RDH13
Retinol dehydrogenase 13

2

1

High-throughput

0.574

High

210716

KLK10
Kallikrein-10

1

5

High-throughput

0.536

High

132994

MATN2
Matrilin-2

1

0

High-throughput

0.513

High

443193

CDK1
Cyclin-dependent kinase 1

1

0

Small-scale

0.480

High

533595

CLUS
Clusterin

1

0

Small-scale

0.458

High

690593

RN181
E3 ubiquitin-protein ligase RNF181

1

1

High-throughput

0.437

High

690591

SFXN5
Sideroflexin-5

2

0

High-throughput

0.328

High

690581

PLK1
Serine/threonine-protein kinase PLK1

1

0

Small-scale

0.296

High

326463

NDUB6
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6

1

0

High-throughput

0.279

Low

690585

UBE2U
Ubiquitin-conjugating enzyme E2 U

1

0

High-throughput

0.279

Low

690588

RYBP
RING1 and YY1-binding protein

1

0

High-throughput

0.279

Low

690594

PHF11
PHD finger protein 11

1

0

High-throughput

0.279

Low

277274

PITX3
Pituitary homeobox 3

1

0

Small-scale

0.249

Low

623115

RO52
E3 ubiquitin-protein ligase TRIM21

1

0

High-throughput

0.249

Low

690586

MILK2
MICAL-like protein 2

1

0

High-throughput

0.249

Low

690590

SNIP1
Smad nuclear-interacting protein 1

1

0

Small-scale

0.249

Low

690592

FACD2
Fanconi anemia group D2 protein

1

0

High-throughput

0.249

Low

254821

HCN1
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

1

0

High-throughput

0.232

Low

690582

CAC1C
Voltage-dependent L-type calcium channel subunit alpha-1C

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025