HitPredict

Interactor 1: EGLN (Q63961)
Endoglin (Cell surface MJ7/18 antigen) (CD antigen CD105)
Gene: Eng

Interactor 2: TGFR1 (Q64729)
TGF-beta receptor type-1 (TGFR-1) (EC 2.7.11.30) (ESK2) (Transforming growth factor-beta receptor type I) (TGF-beta receptor type I) (TbetaR-I)
Gene: Tgfbr1

Species: Mus musculus

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.56 0.60 0.584

The method score is based on:

Property Details
Experiments 24319055, 18337748
Identification Methods affinity chromatography technology, anti bait coimmunoprecipitation
Interaction Type physical association

The annotation score is based on:

Property Details
Interacting Pfam domains -
Common GO terms GO:0001525 - angiogenesis
GO:0003222 - ventricular trabecula myocardium morphogenesis
GO:0005024 - transforming growth factor beta receptor activity
GO:0005114 - type II transforming growth factor beta receptor binding
GO:0007179 - transforming growth factor beta receptor signaling pathway
and 9 others

more...
Homologous interactions 12

Homologous interactions

Color coding for hit scores

1 653
Mm

1 503
+ Mm
+ Hs
+ Mm
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
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+ Hs
+ Mm

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024