HitPredict

Interactor 1: H2A2C (Q64523)
Histone H2A type 2-C (H2A-clustered histone 20) (H2a-613B)
Gene: H2ac20

Interactor 2: CHFR (Q810L3)
E3 ubiquitin-protein ligase CHFR (EC 2.3.2.27) (Checkpoint with forkhead and RING finger domains protein) (RING-type E3 ubiquitin transferase CHFR)
Gene: CHFR

Species: Mus musculus

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	21706008
Identification Methods	enzymatic study
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	Histone~zf-C3HC4_2
Common GO terms	GO:0005634 - nucleus
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 129 Mm			1 664
+	Hs
		282668 H2A2C_HUMAN (1-129): 7.11e-67: 199: 100.00		RNF8_HUMAN (19-386): 1.84e-107: 335: 19.40
+	Hs
		282470 H2A1B_HUMAN (1-127): 8.29e-65: 194: 94.49		RNF8_HUMAN (19-386): 1.84e-107: 335: 19.40
+	Mm
		1145463 H2A2C_MOUSE (1-129): 7.11e-67: 199: 100.00		RNF8_MOUSE (19-385): 5.94e-105: 329: 17.83
+	Hs
		282515 H2AX_HUMAN (1-123): 7.38e-64: 192: 95.12		RNF8_HUMAN (19-386): 1.84e-107: 335: 19.40
+	Hs
		717876 H2A2C_HUMAN (1-129): 7.11e-67: 199: 100.00		BMI1_HUMAN (286-465): 1.49e-41: 155: 18.09
+	Hs
		1087089 H2A2C_HUMAN (1-129): 7.11e-67: 199: 100.00		RING2_HUMAN (273-468): 3.33e-40: 152: 14.95
+	Hs
		1216249 H2A2B_HUMAN (1-126): 2.4e-66: 198: 96.83		RING2_HUMAN (273-468): 3.33e-40: 152: 14.95
+	Hs
		470285 H2A1_HUMAN (1-127): 5.35e-65: 195: 96.06		BMI1_HUMAN (286-465): 1.49e-41: 155: 18.09
+	Hs
		717932 H2A2A_HUMAN (1-127): 3.37e-65: 195: 97.64		BMI1_HUMAN (286-465): 1.49e-41: 155: 18.09
+	Hs
		391572 H2A1B_HUMAN (1-127): 8.29e-65: 194: 94.49		BMI1_HUMAN (286-465): 1.49e-41: 155: 18.09
+	Hs
		1151374 H2A2A_HUMAN (1-127): 3.37e-65: 195: 97.64		RING2_HUMAN (273-468): 3.33e-40: 152: 14.95
+	Hs
		1185208 H2A3_HUMAN (1-127): 5.35e-65: 195: 95.28		RING2_HUMAN (273-468): 3.33e-40: 152: 14.95
+	Hs
		470514 H2A1_HUMAN (1-127): 5.35e-65: 195: 96.06		RING2_HUMAN (273-468): 3.33e-40: 152: 14.95
+	Hs
		555322 H2AX_HUMAN (1-123): 7.38e-64: 192: 95.12		BMI1_HUMAN (286-465): 1.49e-41: 155: 18.09
+	Hs
		391856 H2A1B_HUMAN (1-127): 8.29e-65: 194: 94.49		RING2_HUMAN (273-468): 3.33e-40: 152: 14.95
+	Hs
		391666 H2A1B_HUMAN (1-127): 8.29e-65: 194: 94.49		RING1_HUMAN (267-462): 2.46e-39: 151: 16.19
+	Hs
		555611 H2AX_HUMAN (1-123): 7.38e-64: 192: 95.12		RING2_HUMAN (273-468): 3.33e-40: 152: 14.95
+	Hs
		555425 H2AX_HUMAN (1-123): 7.38e-64: 192: 95.12		RING1_HUMAN (267-462): 2.46e-39: 151: 16.19
+	Hs
		470533 H2A1_HUMAN (1-127): 5.35e-65: 195: 96.06		PCGF1_HUMAN (286-443): 2.91e-35: 135: 17.68
+	Hs
		391879 H2A1B_HUMAN (1-127): 8.29e-65: 194: 94.49		PCGF1_HUMAN (286-443): 2.91e-35: 135: 17.68